MYXXA:Q7BU54

Species (Taxon ID)	Myxococcus xanthus. (34)
Gene Name(s)	frzZ (ECO:0000313 with EMBL:AAC98485.1)
Protein Name(s)	Response regulator FrzZ (ECO:0000313 with EMBL:AAC98485.1)
External Links
UniProt	Q7BU54
EMBL	AF049107
ProteinModelPortal	Q7BU54
IntAct	Q7BU54
GO	GO:0000156 GO:0071976
InterPro	IPR011006 IPR001789
Pfam	PF00072
SMART	SM00448
SUPFAM	SSF52172
PROSITE	PS50110

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0000156	phosphorelay response regulator activity	PMID:17581122	ECO:0000315			F		Fig 4B shows that radiolabelled phosphate is transferred from FrzE when in the presence of FrzZ as seen by the appearnace of a radiolabelled band in lane 3 at the FrzZ position. Fig 4B also shows that both domains of FrzZ are able to be phosphorylated by FrzE through the individual mutation of each domain at an aspartate residue, as seen by a decrease in band intensity at the FrzECheA position and the appearance of a radiolabbelled band at the FrzZ position in lanes 4 & 5. Phosphotransfer can not occur when both domains are mutated concurrently at an aspartate residue as evidenced from a lack of a radiolabelled band at the FrzZ position in lane 6.	complete CACAO 7058
	GO:0071976	cell gliding	PMID:17581122	ECO:0000315			P		Fig. 3 shows that the strain with mutations in both phosphorylation sites in frzZ exhibits the same phenotype as strains that have a complete deletion of frzZ. As seen in Fig 3B, these two strains have inhibited motility, in comparison to the wild-type strain, as evident by a smaller colony diameter on both 0.3% agar and 1.5% agar. Further, strains with a mutation in one of the possible phosphorylation sites exhibited motility similar to wild-type indicating that phosphorylation can occur at one site or the other as well as the role of frzZ in cell motility.	complete CACAO 7188
involved_in	GO:0071976	cell gliding	PMID:17581122	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000156	phosphorelay response regulator activity	PMID:17581122	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000160	phosphorelay signal transduction system	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001789	P		Seeded From UniProt	complete
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References

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