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MYCTU:WHIB1

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Species (Taxon ID) Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332)
Gene Name(s) whiB1
Protein Name(s) Transcriptional regulator WhiB1

Transcriptional regulator WhiB1

External Links
UniProt P9WF42
EMBL AE000516
AL123456
PIR D70596
D70596
RefSeq NP_337843.1
NP_217735.1
YP_006516692.1
ProteinModelPortal P9WF42
P9WF43
EnsemblBacteria AAK47657
CCP46035
GeneID 923069
13318038
887980
KEGG mtc:MT3315
mtu:Rv3219
mtv:RVBD_3219
Proteomes UP000001020
UP000001584
GO GO:0005737
GO:0051539
GO:0035731
GO:0003677
GO:0046872
GO:0006355
GO:0006351
GO:0005737
GO:0051539
GO:0035731
GO:0003677
GO:0046872
GO:0015035
GO:0047134
GO:0055114
GO:0006355
GO:0071731
GO:0006351
HAMAP MF_01479
MF_01479
InterPro IPR003482
IPR003482
Pfam PF02467
PF02467
PROSITE PS51674
PS51674
TubercuList Rv3219
OMA CLKWAIE
PhylomeDB P9WF43

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045892

negative regulation of transcription, DNA-templated

PMID:22464736[1]

ECO:0000314

P

Figure 2. Apo-WhiB1 inhibits transcription of groEL2 in vitro

complete
CACAO 6291

involved_in

GO:0071731

response to nitric oxide

PMID:20929442[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

PMID:20929442[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0047134

protein-disulfide reductase activity

PMID:17157031[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0015035

protein disulfide oxidoreductase activity

PMID:19121228[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:20929442[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:22464736[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002215809
UniProtKB:P9WF39
UniProtKB:P9WF41
UniProtKB:P9WF43

F

Seeded From UniProt

complete

enables

GO:0047134

protein-disulfide reductase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002215809
UniProtKB:P9WF39
UniProtKB:P9WF43

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002215809
UniProtKB:P9WF43

P

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002215809
UniProtKB:P9WF41

P

Seeded From UniProt

complete

enables

GO:0015035

protein disulfide oxidoreductase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002215809
UniProtKB:P9WF41
UniProtKB:P9WF43

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002215809
UniProtKB:P9WF39
UniProtKB:P9WF41
UniProtKB:P9WF43

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0047134

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015035

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0047134

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015035

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000110774

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000110774

P

Seeded From UniProt

complete

enables

GO:0035731

dinitrosyl-iron complex binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000110774

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000110774

F

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000110774

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0004

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0051536

iron-sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0411

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Stapleton, MR et al. (2012) Mycobacterium tuberculosis WhiB1 represses transcription of the essential chaperonin GroEL2. Tuberculosis (Edinb) 92 328-32 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Smith, LJ et al. (2010) Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster. Biochem. J. 432 417-27 PubMed GONUTS page
  3. ↑ Garg, SK et al. (2007) Characterization of Mycobacterium tuberculosis WhiB1/Rv3219 as a protein disulfide reductase. Protein Expr. Purif. 52 422-32 PubMed GONUTS page
  4. ↑ Garg, S et al. (2009) Redox biology of Mycobacterium tuberculosis H37Rv: protein-protein interaction between GlgB and WhiB1 involves exchange of thiol-disulfide. BMC Biochem. 10 1 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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