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MYCTU:TOP1
Contents
| Species (Taxon ID) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332) | |
| Gene Name(s) | topA (ECO:0000255 with HAMAP-Rule:MF_00952) | |
| Protein Name(s) | DNA topoisomerase 1 (ECO:0000255 with HAMAP-Rule:MF_00952)
DNA topoisomerase I (ECO:0000255 with HAMAP-Rule:MF_00952) Omega-protein Relaxing enzyme Swivelase Untwisting enzyme | |
| External Links | ||
| UniProt | P9WG49 | |
| EMBL | AL123456 U40159 | |
| PIR | G70563 | |
| RefSeq | NP_218163.1 YP_006517133.1 | |
| ProteinModelPortal | P9WG49 | |
| SMR | P9WG49 | |
| GeneID | 13317254 885608 | |
| KEGG | mtu:Rv3646c mtv:RVBD_3646c | |
| TubercuList | Rv3646c | |
| KO | K03168 | |
| OMA | FGPYVVH | |
| PhylomeDB | P9WG49 | |
| Proteomes | UP000001584 | |
| GO | GO:0005618 GO:0005829 GO:0005886 GO:0003677 GO:0003917 GO:0000287 GO:0006265 GO:0040007 GO:0060701 | |
| Gene3D | 1.10.460.10 2.70.20.10 3.40.50.140 | |
| HAMAP | MF_00952 | |
| InterPro | IPR000380 IPR003601 IPR023406 IPR013497 IPR013824 IPR013825 IPR023405 IPR003602 IPR005733 IPR028612 IPR025589 IPR006171 | |
| PANTHER | PTHR11390 | |
| Pfam | PF01131 PF01751 PF13368 | |
| PRINTS | PR00417 | |
| SMART | SM00437 SM00436 SM00493 | |
| SUPFAM | SSF56712 | |
| TIGRFAMs | TIGR01051 | |
| PROSITE | PS00396 PS50880 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005618 |
cell wall |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005618 |
cell wall |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060701 |
negative regulation of ribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003917 |
DNA topoisomerase type I activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000380 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003916 |
DNA topoisomerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR003601 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003917 |
DNA topoisomerase type I activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000380 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000106158 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003917 |
DNA topoisomerase type I activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000106158 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016853 |
isomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003916 |
DNA topoisomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
- ↑ Gu, S et al. (2003) Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol. Cell Proteomics 2 1284-96 PubMed GONUTS page
- ↑ Wolfe, LM et al. (2010) Proteomic definition of the cell wall of Mycobacterium tuberculosis. J. Proteome Res. 9 5816-26 PubMed GONUTS page
- ↑ Huang, F & He, ZG (2010) Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495 and its sole DNA topoisomerase I. Nucleic Acids Res. 38 8219-30 PubMed GONUTS page
- ↑ 5.0 5.1 Yang, F et al. (1996) Cloning, expression, purification and characterization of DNA topoisomerase I of Mycobacterium tuberculosis. Gene 178 63-9 PubMed GONUTS page
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