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MYCTU:RELA
Contents
| Species (Taxon ID) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332) | |
| Gene Name(s) | relA | |
| Protein Name(s) | Bifunctional (p)ppGpp synthase/hydrolase RelA
GTP pyrophosphokinase (p)ppGpp synthase ATP:GTP 3'-pyrophosphotransferase Stringent response-like protein ppGpp synthase II Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase Penta-phosphate guanosine-3'-pyrophosphohydrolase (ppGpp)ase | |
| External Links | ||
| UniProt | P9WHG9 | |
| EMBL | AL123456 | |
| PIR | F70725 | |
| RefSeq | NP_217099.1 YP_006516024.1 | |
| ProteinModelPortal | P9WHG9 | |
| SMR | P9WHG9 | |
| GeneID | 13319303 887888 | |
| KEGG | mtu:Rv2583c mtv:RVBD_2583c | |
| TubercuList | Rv2583c | |
| KO | K00951 | |
| UniPathway | UPA00908 UPA00908 | |
| Proteomes | UP000001584 | |
| GO | GO:0005618 GO:0005886 GO:0016597 GO:0005524 GO:0005525 GO:0008728 GO:0008893 GO:0016301 GO:0030145 GO:0015970 GO:0009405 GO:0015968 | |
| Gene3D | 3.10.20.30 | |
| InterPro | IPR002912 IPR012675 IPR003607 IPR004811 IPR007685 IPR004095 IPR012676 | |
| Pfam | PF04607 PF02824 | |
| SMART | SM00471 SM00954 | |
| SUPFAM | SSF81271 | |
| TIGRFAMs | TIGR00691 | |
| PROSITE | PS51671 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005618 |
cell wall |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030145 |
manganese ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015968 |
stringent response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008893 |
guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008893 |
guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008728 |
GTP diphosphokinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000479633 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005618 |
cell wall |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000479633 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0015969 |
guanosine tetraphosphate metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008728 |
GTP diphosphokinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008893 |
guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015970 |
guanosine tetraphosphate biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00908 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Avarbock, D et al. (1999) Cloning and characterization of a bifunctional RelA/SpoT homologue from Mycobacterium tuberculosis. Gene 233 261-9 PubMed GONUTS page
- ↑ Primm, TP et al. (2000) The stringent response of Mycobacterium tuberculosis is required for long-term survival. J. Bacteriol. 182 4889-98 PubMed GONUTS page
- ↑ Dahl, JL et al. (2003) The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice. Proc. Natl. Acad. Sci. U.S.A. 100 10026-31 PubMed GONUTS page
- ↑ Avarbock, D et al. (2000) Differential regulation of opposing RelMtb activities by the aminoacylation state of a tRNA.ribosome.mRNA.RelMtb complex. Biochemistry 39 11640-8 PubMed GONUTS page
- ↑ 6.0 6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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