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MYCTU:RECA

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Species (Taxon ID) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332)
Gene Name(s) recA
Protein Name(s) Protein RecA

Recombinase A Endonuclease PI-MtuI Mtu RecA intein

External Links
UniProt P9WHJ3
EMBL X58485
AJ000012
AJ000011
AL123456
PIR S18206
RefSeq NP_217253.1
YP_006516181.1
PDB 1G18
1G19
1MO3
1MO4
1MO5
1MO6
2IMZ
2IN0
2IN8
2IN9
2L8L
3IFJ
3IGD
PDBsum 1G18
1G19
1MO3
1MO4
1MO5
1MO6
2IMZ
2IN0
2IN8
2IN9
2L8L
3IFJ
3IGD
ProteinModelPortal P9WHJ3
SMR P9WHJ3
BindingDB P9WHJ3
ChEMBL CHEMBL1741171
GeneID 13319464
888371
KEGG mtu:Rv2737c
mtv:RVBD_2737c
TubercuList Rv2737c
KO K03553
OMA DQGTQDV
PhylomeDB P9WHJ3
Proteomes UP000001584
GO GO:0005829
GO:0005524
GO:0016887
GO:0008094
GO:0004520
GO:0000287
GO:0030145
GO:0000150
GO:0003697
GO:0006200
GO:0006974
GO:0000737
GO:0016539
GO:0006314
GO:0000725
GO:0046677
GO:0009432
GO:0042148
GO:0009650
Gene3D 2.170.16.10
3.10.28.10
3.30.250.10
3.40.50.300
HAMAP MF_00268
InterPro IPR003593
IPR013765
IPR020584
IPR028992
IPR003586
IPR003587
IPR027434
IPR006142
IPR004042
IPR006141
IPR027417
IPR020588
IPR023400
IPR020587
PANTHER PTHR22942:SF1
Pfam PF14528
PF00154
PRINTS PR00379
PR00142
SMART SM00382
SM00305
SM00306
SUPFAM SSF51294
SSF52540
SSF54752
SSF55608
TIGRFAMs TIGR01443
TIGR01445
TIGR02012
PROSITE PS50818
PS50819
PS50817
PS00321
PS50162
PS50163

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005829

cytosol

PMID:15525680[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0046677

response to antibiotic

PMID:18799471[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042148

strand invasion

PMID:10074373[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030145

manganese ion binding

PMID:12853636[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030145

manganese ion binding

PMID:11850426[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

PMID:8639660[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009650

UV protection

PMID:1909321[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008094

DNA-dependent ATPase activity

PMID:12853636[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:9171394[8]

ECO:0000316

genetic interaction evidence used in manual assertion

P

Seeded From UniProt

Missing: with/from

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:11443079[9]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:11850426[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:11121488[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:10074373[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:8639660[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004520

endodeoxyribonuclease activity

PMID:11850426[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

PMID:8639660[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000725

recombinational repair

PMID:1909321[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

PMID:12853636[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

PMID:12167644[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000150

recombinase activity

PMID:10074373[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[12]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000534715
UniProtKB:P9WHJ3

C

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004519

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004519

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004518

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020584
InterPro:IPR020587
InterPro:IPR020588

F

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013765

F

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004042
InterPro:IPR004860

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013765
InterPro:IPR020584
InterPro:IPR020587
InterPro:IPR020588

F

Seeded From UniProt

complete

involved_in

GO:0006259

DNA metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020584
InterPro:IPR020587

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013765
InterPro:IPR020588

P

Seeded From UniProt

complete

enables

GO:0008094

DNA-dependent ATPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020584
InterPro:IPR020587
InterPro:IPR020588

F

Seeded From UniProt

complete

involved_in

GO:0016539

intein-mediated protein splicing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006141
InterPro:IPR006142

P

Seeded From UniProt

complete

enables

GO:0003684

damaged DNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000083075

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000083075

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000083075

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000083075

C

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000083075

F

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000083075

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000083075

F

Seeded From UniProt

complete

enables

GO:0008094

DNA-dependent ATPase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000083075

F

Seeded From UniProt

complete

involved_in

GO:0009432

SOS response

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000083075

P

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

involved_in

GO:0009432

SOS response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0742

P

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0255

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006314

intron homing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0404

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0233

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
  2. O'Sullivan, DM et al. (2008) Mycobacterium tuberculosis DNA repair in response to subinhibitory concentrations of ciprofloxacin. J. Antimicrob. Chemother. 62 1199-202 PubMed GONUTS page
  3. 3.0 3.1 3.2 Vaze, MB & Muniyappa, K (1999) RecA protein of Mycobacterium tuberculosis possesses pH-dependent homologous DNA pairing and strand exchange activities: implications for allele exchange in mycobacteria. Biochemistry 38 3175-86 PubMed GONUTS page
  4. 4.0 4.1 4.2 Guhan, N & Muniyappa, K (2003) Mycobacterium tuberculosis RecA intein, a LAGLIDADG homing endonuclease, displays Mn(2+) and DNA-dependent ATPase activity. Nucleic Acids Res. 31 4184-91 PubMed GONUTS page
  5. 5.0 5.1 5.2 Guhan, N & Muniyappa, K (2002) Mycobacterium tuberculosis RecA intein possesses a novel ATP-dependent site-specific double-stranded DNA endonuclease activity. J. Biol. Chem. 277 16257-64 PubMed GONUTS page
  6. 6.0 6.1 6.2 Kumar, RA et al. (1996) Functional characterization of the precursor and spliced forms of RecA protein of Mycobacterium tuberculosis. Biochemistry 35 1793-802 PubMed GONUTS page
  7. 7.0 7.1 Davis, EO et al. (1991) Novel structure of the recA locus of Mycobacterium tuberculosis implies processing of the gene product. J. Bacteriol. 173 5653-62 PubMed GONUTS page
  8. Movahedzadeh, F et al. (1997) Determination of DNA sequences required for regulated Mycobacterium tuberculosis RecA expression in response to DNA-damaging agents suggests that two modes of regulation exist. J. Bacteriol. 179 3509-18 PubMed GONUTS page
  9. Brooks, PC et al. (2001) Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. J. Bacteriol. 183 4459-67 PubMed GONUTS page
  10. Datta, S et al. (2000) Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation. Nucleic Acids Res. 28 4964-73 PubMed GONUTS page
  11. Guhan, N & Muniyappa, K (2002) The RecA intein of Mycobacterium tuberculosis promotes cleavage of ectopic DNA sites. Implications for the dispersal of inteins in natural populations. J. Biol. Chem. 277 40352-61 PubMed GONUTS page
  12. Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page