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MYCTU:RECA
Contents
Species (Taxon ID) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332) | |
Gene Name(s) | recA | |
Protein Name(s) | Protein RecA
Recombinase A Endonuclease PI-MtuI Mtu RecA intein | |
External Links | ||
UniProt | P9WHJ3 | |
EMBL | X58485 AJ000012 AJ000011 AL123456 | |
PIR | S18206 | |
RefSeq | NP_217253.1 YP_006516181.1 | |
PDB | 1G18 1G19 1MO3 1MO4 1MO5 1MO6 2IMZ 2IN0 2IN8 2IN9 2L8L 3IFJ 3IGD | |
PDBsum | 1G18 1G19 1MO3 1MO4 1MO5 1MO6 2IMZ 2IN0 2IN8 2IN9 2L8L 3IFJ 3IGD | |
ProteinModelPortal | P9WHJ3 | |
SMR | P9WHJ3 | |
BindingDB | P9WHJ3 | |
ChEMBL | CHEMBL1741171 | |
GeneID | 13319464 888371 | |
KEGG | mtu:Rv2737c mtv:RVBD_2737c | |
TubercuList | Rv2737c | |
KO | K03553 | |
OMA | DQGTQDV | |
PhylomeDB | P9WHJ3 | |
Proteomes | UP000001584 | |
GO | GO:0005829 GO:0005524 GO:0016887 GO:0008094 GO:0004520 GO:0000287 GO:0030145 GO:0000150 GO:0003697 GO:0006200 GO:0006974 GO:0000737 GO:0016539 GO:0006314 GO:0000725 GO:0046677 GO:0009432 GO:0042148 GO:0009650 | |
Gene3D | 2.170.16.10 3.10.28.10 3.30.250.10 3.40.50.300 | |
HAMAP | MF_00268 | |
InterPro | IPR003593 IPR013765 IPR020584 IPR028992 IPR003586 IPR003587 IPR027434 IPR006142 IPR004042 IPR006141 IPR027417 IPR020588 IPR023400 IPR020587 | |
PANTHER | PTHR22942:SF1 | |
Pfam | PF14528 PF00154 | |
PRINTS | PR00379 PR00142 | |
SMART | SM00382 SM00305 SM00306 | |
SUPFAM | SSF51294 SSF52540 SSF54752 SSF55608 | |
TIGRFAMs | TIGR01443 TIGR01445 TIGR02012 | |
PROSITE | PS50818 PS50819 PS50817 PS00321 PS50162 PS50163 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0005829 |
cytosol |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046677 |
response to antibiotic |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042148 |
strand invasion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0030145 |
manganese ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0030145 |
manganese ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016887 |
ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009650 |
UV protection |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008094 |
DNA-dependent ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004520 |
endodeoxyribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003697 |
single-stranded DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000725 |
recombinational repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000150 |
recombinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000534715 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004519 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004519 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004518 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003697 |
single-stranded DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004519 |
endonuclease activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR013765 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006259 |
DNA metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008094 |
DNA-dependent ATPase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016539 |
intein-mediated protein splicing |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003684 |
damaged DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000083075 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000083075 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000083075 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000083075 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003697 |
single-stranded DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000083075 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006310 |
DNA recombination |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000083075 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000083075 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008094 |
DNA-dependent ATPase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000083075 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009432 |
SOS response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000083075 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004518 |
nuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009432 |
SOS response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004519 |
endonuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006314 |
intron homing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006310 |
DNA recombination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
- ↑ O'Sullivan, DM et al. (2008) Mycobacterium tuberculosis DNA repair in response to subinhibitory concentrations of ciprofloxacin. J. Antimicrob. Chemother. 62 1199-202 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Vaze, MB & Muniyappa, K (1999) RecA protein of Mycobacterium tuberculosis possesses pH-dependent homologous DNA pairing and strand exchange activities: implications for allele exchange in mycobacteria. Biochemistry 38 3175-86 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Guhan, N & Muniyappa, K (2003) Mycobacterium tuberculosis RecA intein, a LAGLIDADG homing endonuclease, displays Mn(2+) and DNA-dependent ATPase activity. Nucleic Acids Res. 31 4184-91 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Guhan, N & Muniyappa, K (2002) Mycobacterium tuberculosis RecA intein possesses a novel ATP-dependent site-specific double-stranded DNA endonuclease activity. J. Biol. Chem. 277 16257-64 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Kumar, RA et al. (1996) Functional characterization of the precursor and spliced forms of RecA protein of Mycobacterium tuberculosis. Biochemistry 35 1793-802 PubMed GONUTS page
- ↑ 7.0 7.1 Davis, EO et al. (1991) Novel structure of the recA locus of Mycobacterium tuberculosis implies processing of the gene product. J. Bacteriol. 173 5653-62 PubMed GONUTS page
- ↑ Movahedzadeh, F et al. (1997) Determination of DNA sequences required for regulated Mycobacterium tuberculosis RecA expression in response to DNA-damaging agents suggests that two modes of regulation exist. J. Bacteriol. 179 3509-18 PubMed GONUTS page
- ↑ Brooks, PC et al. (2001) Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. J. Bacteriol. 183 4459-67 PubMed GONUTS page
- ↑ Datta, S et al. (2000) Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation. Nucleic Acids Res. 28 4964-73 PubMed GONUTS page
- ↑ Guhan, N & Muniyappa, K (2002) The RecA intein of Mycobacterium tuberculosis promotes cleavage of ectopic DNA sites. Implications for the dispersal of inteins in natural populations. J. Biol. Chem. 277 40352-61 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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