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MYCTU:PTPA

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Species (Taxon ID) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332)
Gene Name(s) ptpA
Protein Name(s) Probable low molecular weight protein-tyrosine-phosphatase

PTPase

External Links
UniProt P9WIA1
EMBL AL123456
PIR F70777
RefSeq NP_216750.1
YP_006515656.1
PDB 1U2P
1U2Q
1ZOJ
2LUO
PDBsum 1U2P
1U2Q
1ZOJ
2LUO
ProteinModelPortal P9WIA1
SMR P9WIA1
BindingDB P9WIA1
ChEMBL CHEMBL4542
GeneID 13318925
887373
KEGG mtu:Rv2234
mtv:RVBD_2234
TubercuList Rv2234
KO K01104
OMA GSWHIGK
PhylomeDB P9WIA1
Proteomes UP000001584
GO GO:0005576
GO:0044174
GO:0005886
GO:0004725
GO:0052046
GO:0052083
GO:0009405
GO:0035335
GO:0006470
InterPro IPR023485
IPR000106
IPR017867
PANTHER PTHR11717:SF7
Pfam PF01451
PRINTS PR00719
SMART SM00226
SUPFAM SSF52788

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005886

plasma membrane

PMID:15525680[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0052083

negative regulation by symbiont of host cell-mediated immune response

PMID:18474358[2]

ECO:0000269

experimental evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0052046

modification by symbiont of host morphology or physiology via secreted substance

PMID:16085396[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

PMID:18474358[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

PMID:10986245[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:10986245[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

PMID:12066895[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

PMID:10986245[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

NOT|enables

GO:0004438

phosphatidylinositol-3-phosphatase activity

PMID:15753315[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13567
EcoGene:EG13727
FB:FBgn0040076
PANTHER:PTN000197212
PomBase:SPAC1071.12c
RGD:2020
SGD:S000006277
UniProtKB:P9WIA1

F

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017867

F

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017867

P

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.48

F

Seeded From UniProt

complete

part_of

GO:0030430

host cell cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1035
UniProtKB-SubCell:SL-0381

C

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0843

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0044174

host cell endosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1039
UniProtKB-SubCell:SL-0393

C

Seeded From UniProt

complete

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
  2. ↑ 2.0 2.1 Bach, H et al. (2008) Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B. Cell Host Microbe 3 316-22 PubMed GONUTS page
  3. ↑ Castandet, J et al. (2005) Tyrosine phosphatase MptpA of Mycobacterium tuberculosis inhibits phagocytosis and increases actin polymerization in macrophages. Res. Microbiol. 156 1005-13 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Koul, A et al. (2000) Cloning and characterization of secretory tyrosine phosphatases of Mycobacterium tuberculosis. J. Bacteriol. 182 5425-32 PubMed GONUTS page
  5. ↑ Cowley, SC et al. (2002) Expression and localization of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Res. Microbiol. 153 233-41 PubMed GONUTS page
  6. ↑ Vergne, I et al. (2005) Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 102 4033-8 PubMed GONUTS page
  7. ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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