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MYCTU:PKNH
Contents
| Species (Taxon ID) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332) | |
| Gene Name(s) | pknH | |
| Protein Name(s) | Serine/threonine-protein kinase PknH | |
| External Links | ||
| UniProt | P9WI71 | |
| EMBL | AL123456 | |
| PIR | B70754 | |
| RefSeq | NP_215782.1 WP_010886110.1 | |
| PDB | 4ESQ | |
| PDBsum | 4ESQ | |
| ProteinModelPortal | P9WI71 | |
| SMR | P9WI71 | |
| GeneID | 887023 | |
| KEGG | mtu:Rv1266c | |
| TubercuList | Rv1266c | |
| KO | K08884 | |
| OMA | APERFAN | |
| Proteomes | UP000001584 | |
| GO | GO:0005618 GO:0005887 GO:0005524 GO:0004672 GO:0004674 GO:0043086 GO:0045926 GO:0043085 GO:0043388 GO:0045893 GO:0046777 GO:0046890 GO:0052572 | |
| InterPro | IPR011009 IPR026954 IPR000719 IPR017441 IPR008271 | |
| Pfam | PF00069 PF14032 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0052572 |
response to host immune response |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046890 |
regulation of lipid biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046777 |
protein autophosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045926 |
negative regulation of growth |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0045927 |
positive regulation of growth |
ECO:0000314 |
P |
Figure 4b. pknH is required for diazotrophic growth |
complete | |||||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043388 |
positive regulation of DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043388 |
positive regulation of DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043086 |
negative regulation of catalytic activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043085 |
positive regulation of catalytic activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005618 |
cell wall |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Sharma, K et al. (2006) Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo. J. Bacteriol. 188 2936-44 PubMed GONUTS page
- ↑ 2.0 2.1 Molle, V et al. (2003) An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosis. Biochemistry 42 15300-9 PubMed GONUTS page
- ↑ Papavinasasundaram, KG et al. (2005) Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice. J. Bacteriol. 187 5751-60 PubMed GONUTS page
- ↑ Ehira, S & Ohmori, M (2012) The pknH gene restrictively expressed in heterocysts is required for diazotrophic growth in the cyanobacterium Anabaena sp. strain PCC 7120. Microbiology (Reading, Engl.) 158 1437-43 PubMed GONUTS page
- ↑ Sharma, K et al. (2006) EmbR, a regulatory protein with ATPase activity, is a substrate of multiple serine/threonine kinases and phosphatase in Mycobacterium tuberculosis. FEBS J. 273 2711-21 PubMed GONUTS page
- ↑ 6.0 6.1 Sharma, K et al. (2004) PknH, a transmembrane Hank's type serine/threonine kinase from Mycobacterium tuberculosis is differentially expressed under stress conditions. FEMS Microbiol. Lett. 233 107-13 PubMed GONUTS page
- ↑ Molle, V et al. (2008) EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR. Biochem. J. 410 309-17 PubMed GONUTS page
- ↑ Zheng, X et al. (2007) Novel substrates of Mycobacterium tuberculosis PknH Ser/Thr kinase. Biochem. Biophys. Res. Commun. 355 162-8 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Molle, V et al. (2006) The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation. J. Biol. Chem. 281 30094-103 PubMed GONUTS page
- ↑ Wolfe, LM et al. (2010) Proteomic definition of the cell wall of Mycobacterium tuberculosis. J. Proteome Res. 9 5816-26 PubMed GONUTS page
b
m
n
p
- GO:0016310 ! phosphorylation
- GO:0005886 ! plasma membrane
- GO:0043085 ! positive regulation of catalytic activity
- GO:0043388 ! positive regulation of DNA binding
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0045927 ! positive regulation of growth
- GO:0046777 ! protein autophosphorylation
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
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