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MYCTU:P71814

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Species (Taxon ID) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332)
Gene Name(s) phoP (ECO:0000313 with EMBL:CCP43504.1)
Protein Name(s) OmpR family two-component system response regulator (ECO:0000313 with EMBL:AFN48633.1)

Possible two component system response transcriptional positive regulator PhoP (ECO:0000313 with EMBL:CCP43504.1)

External Links
UniProt P71814
EMBL CP003248
AL123456
JLDD01000006
RefSeq NP_215271.1
YP_006514104.1
PDB 3R0J
PDBsum 3R0J
SMR P71814
STRING 83332.Rv0757
EnsemblBacteria AFN48633
CCP43504
GeneID 13318651
888772
KEGG mtu:Rv0757
mtv:RVBD_0757
PATRIC 18150200
KO K02483
OMA WGGDANI
OrthoDB EOG6G4VQG
PhylomeDB P71814
BioCyc MTBRV:RV0757-MONOMER
Proteomes UP000001584
UP000003123
GO GO:0005886
GO:0003677
GO:0009247
GO:0045892
GO:0009405
GO:0000160
GO:0010628
GO:0046889
GO:0045893
GO:0044315
GO:0006979
GO:0006351
Gene3D 1.10.10.10
InterPro IPR011006
IPR001867
IPR016032
IPR001789
IPR011991
Pfam PF00072
PF00486
SMART SM00448
SM00862
SUPFAM SSF46894
SSF52172
PROSITE PS50110

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0046889

positive regulation of lipid biosynthetic process

PMID:22072719[1]

ECO:0000315

P

Fig. 1BC

complete
CACAO 3186

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:16573683[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0010628

positive regulation of gene expression

PMID:22072719[1]

ECO:0000315

P

Fig. 2 and Fig. 3

complete
CACAO 3187

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:16573683[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044315

protein secretion by the type VII secretion system

PMID:18282096[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

PMID:18282096[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

PMID:16573683[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009247

glycolipid biosynthetic process

PMID:16326699[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009247

glycolipid biosynthetic process

PMID:12368436[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

PMID:16573683[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15525680[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:14532352[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0046889

positive regulation of lipid biosynthetic process

PMID:22072719[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:22072719[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10020
EcoGene:EG10061
EcoGene:EG10731
EcoGene:EG11618
PANTHER:PTN000724188
UniProtKB:P9WGM1

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10020
EcoGene:EG10061
EcoGene:EG14045
PANTHER:PTN000724188

F

Seeded From UniProt

complete

enables

GO:0000156

phosphorelay response regulator activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10061
EcoGene:EG10672
EcoGene:EG11615
EcoGene:EG12615
PANTHER:PTN000724188
UniProtKB:O07776
UniProtKB:P37478
UniProtKB:Q9I2U3

F

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001789
InterPro:IPR001867

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001867
InterPro:IPR016032

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001867
InterPro:IPR016032

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0902

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000414392

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Goyal, R et al. (2011) Phosphorylation of PhoP protein plays direct regulatory role in lipid biosynthesis of Mycobacterium tuberculosis. J. Biol. Chem. 286 45197-208 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Walters, SB et al. (2006) The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 60 312-30 PubMed GONUTS page
  3. 3.0 3.1 Frigui, W et al. (2008) Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. PLoS Pathog. 4 e33 PubMed GONUTS page
  4. Gonzalo Asensio, J et al. (2006) The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 281 1313-6 PubMed GONUTS page
  5. Ludwiczak, P et al. (2002) Mycobacterium tuberculosis phoP mutant: lipoarabinomannan molecular structure. Microbiology (Reading, Engl.) 148 3029-37 PubMed GONUTS page
  6. Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
  7. Gu, S et al. (2003) Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol. Cell Proteomics 2 1284-96 PubMed GONUTS page
  8. 8.0 8.1 8.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page