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MYCTU:P71814
Contents
Species (Taxon ID) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332) | |
Gene Name(s) | phoP (ECO:0000313 with EMBL:CCP43504.1) | |
Protein Name(s) | OmpR family two-component system response regulator (ECO:0000313 with EMBL:AFN48633.1)
Possible two component system response transcriptional positive regulator PhoP (ECO:0000313 with EMBL:CCP43504.1) | |
External Links | ||
UniProt | P71814 | |
EMBL | CP003248 AL123456 JLDD01000006 | |
RefSeq | NP_215271.1 YP_006514104.1 | |
PDB | 3R0J | |
PDBsum | 3R0J | |
SMR | P71814 | |
STRING | 83332.Rv0757 | |
EnsemblBacteria | AFN48633 CCP43504 | |
GeneID | 13318651 888772 | |
KEGG | mtu:Rv0757 mtv:RVBD_0757 | |
PATRIC | 18150200 | |
KO | K02483 | |
OMA | WGGDANI | |
OrthoDB | EOG6G4VQG | |
PhylomeDB | P71814 | |
BioCyc | MTBRV:RV0757-MONOMER | |
Proteomes | UP000001584 UP000003123 | |
GO | GO:0005886 GO:0003677 GO:0009247 GO:0045892 GO:0009405 GO:0000160 GO:0010628 GO:0046889 GO:0045893 GO:0044315 GO:0006979 GO:0006351 | |
Gene3D | 1.10.10.10 | |
InterPro | IPR011006 IPR001867 IPR016032 IPR001789 IPR011991 | |
Pfam | PF00072 PF00486 | |
SMART | SM00448 SM00862 | |
SUPFAM | SSF46894 SSF52172 | |
PROSITE | PS50110 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0046889 |
positive regulation of lipid biosynthetic process |
ECO:0000315 |
P |
Fig. 1BC |
complete | |||||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
P |
Fig. 2 and Fig. 3 |
complete | |||||
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0044315 |
protein secretion by the type VII secretion system |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009247 |
glycolipid biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009247 |
glycolipid biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006979 |
response to oxidative stress |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046889 |
positive regulation of lipid biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10020 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10020 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000156 |
phosphorelay response regulator activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10061 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000160 |
phosphorelay signal transduction system |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000160 |
phosphorelay signal transduction system |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000414392 |
F |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Goyal, R et al. (2011) Phosphorylation of PhoP protein plays direct regulatory role in lipid biosynthesis of Mycobacterium tuberculosis. J. Biol. Chem. 286 45197-208 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Walters, SB et al. (2006) The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis. Mol. Microbiol. 60 312-30 PubMed GONUTS page
- ↑ 3.0 3.1 Frigui, W et al. (2008) Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP. PLoS Pathog. 4 e33 PubMed GONUTS page
- ↑ Gonzalo Asensio, J et al. (2006) The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis. J. Biol. Chem. 281 1313-6 PubMed GONUTS page
- ↑ Ludwiczak, P et al. (2002) Mycobacterium tuberculosis phoP mutant: lipoarabinomannan molecular structure. Microbiology (Reading, Engl.) 148 3029-37 PubMed GONUTS page
- ↑ Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
- ↑ Gu, S et al. (2003) Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol. Cell Proteomics 2 1284-96 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
b
m
p
- GO:0000160 ! phosphorelay signal transduction system
- GO:0000156 ! phosphorelay response regulator activity
- GO:0005886 ! plasma membrane
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0010628 ! positive regulation of gene expression
- GO:0046889 ! positive regulation of lipid biosynthetic process
- GO:0044315 ! protein secretion by the type VII secretion system