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MYCTU:OTSB

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Species (Taxon ID) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332)
Gene Name(s) otsB (synonyms: otsB2)
Protein Name(s) Trehalose-phosphate phosphatase

TPP Trehalose-6-phosphate phosphatase

External Links
UniProt P9WFZ5
EMBL AL123456
PIR C70972
RefSeq NP_217889.1
YP_006516854.1
ProteinModelPortal P9WFZ5
SMR P9WFZ5
GeneID 13316972
888137
KEGG mtu:Rv3372
mtv:RVBD_3372
TubercuList Rv3372
KO K01087
OMA GMDIMAS
PhylomeDB P9WFZ5
Reactome REACT_27232
UniPathway UPA00299
Proteomes UP000001584
GO GO:0005886
GO:0000287
GO:0004805
GO:0016311
GO:0040007
GO:0005992
Gene3D 3.40.50.1000
InterPro IPR023214
IPR006379
IPR003337
Pfam PF02358
SUPFAM SSF56784
TIGRFAMs TIGR01484
TIGR00685

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0004805

trehalose-phosphatase activity

PMID:15703182[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15525680[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

PMID:15703182[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0005992

trehalose biosynthetic process

PMID:15708675[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004805

trehalose-phosphatase activity

PMID:15708675[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

PMID:15708675[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

PMID:15703182[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003337

F

Seeded From UniProt

complete

involved_in

GO:0005992

trehalose biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003337

P

Seeded From UniProt

complete

enables

GO:0004805

trehalose-phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.12

F

Seeded From UniProt

complete

involved_in

GO:0005992

trehalose biosynthetic process

Reactome:R-MTU-868688

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-MTU-868608

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0005992

trehalose biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00299

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Murphy, HN et al. (2005) The OtsAB pathway is essential for trehalose biosynthesis in Mycobacterium tuberculosis. J. Biol. Chem. 280 14524-9 PubMed GONUTS page
  2. Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
  3. 3.0 3.1 3.2 Zhang, H et al. (2005) Analysis and determination of biological activity of short-chain peptides from porcine brain hydrolysate. J Pharm Biomed Anal 37 333-9 PubMed GONUTS page