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MYCTU:OTSA
Contents
| Species (Taxon ID) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332) | |
| Gene Name(s) | otsA | |
| Protein Name(s) | Trehalose-phosphate synthase
TPS Trehalose-6-phosphate synthase | |
| External Links | ||
| UniProt | P9WN11 | |
| EMBL | AL123456 | |
| PIR | G70569 | |
| RefSeq | NP_218007.1 YP_006516979.1 | |
| ProteinModelPortal | P9WN11 | |
| SMR | P9WN11 | |
| GeneID | 13317097 888404 | |
| KEGG | mtu:Rv3490 mtv:RVBD_3490 | |
| TubercuList | Rv3490 | |
| KO | K00697 | |
| OMA | VVGFHIP | |
| PhylomeDB | P9WN11 | |
| Reactome | REACT_27232 | |
| UniPathway | UPA00299 | |
| Proteomes | UP000001584 | |
| GO | GO:0005618 GO:0005886 GO:0047260 GO:0003825 GO:0030145 GO:0040007 GO:0005992 | |
| InterPro | IPR001830 | |
| Pfam | PF00982 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005992 |
trehalose biosynthetic process |
ECO:0000314 |
P |
Fig.4 synthesis of trehalose using UDP-Glc and GDP-Glc correlates with amount or enzyme and has a linear relationship with time Fig.5 increased trehalose-P synthesized correlates with increase amount of TPS protein. |
complete | |||||
|
involved_in |
GO:0005992 |
trehalose biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005618 |
cell wall |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005618 |
cell wall |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047260 |
alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030145 |
manganese ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005992 |
trehalose biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003825 |
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070415 |
trehalose metabolism in response to cold stress |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11751 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070413 |
trehalose metabolism in response to stress |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000082159 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0047260 |
alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001646917 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030145 |
manganese ion binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001646917 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11751 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006970 |
response to osmotic stress |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11751 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0005992 |
trehalose biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11751 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11751 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000082159 |
C |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0004805 |
trehalose-phosphatase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0027560 |
F |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0003825 |
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
CGD:CAL0000182821 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004805 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005992 |
trehalose biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003825 |
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005992 |
trehalose biosynthetic process |
Reactome:R-MTU-868688 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-MTU-868622 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016757 |
transferase activity, transferring glycosyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0005992 |
trehalose biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00299 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Pan, YT et al. (2002) Trehalose-phosphate synthase of Mycobacterium tuberculosis. Cloning, expression and properties of the recombinant enzyme. Eur. J. Biochem. 269 6091-100 PubMed GONUTS page
- ↑ Gu, S et al. (2003) Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol. Cell Proteomics 2 1284-96 PubMed GONUTS page
- ↑ Wolfe, LM et al. (2010) Proteomic definition of the cell wall of Mycobacterium tuberculosis. J. Proteome Res. 9 5816-26 PubMed GONUTS page
- ↑ Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
- ↑ 5.0 5.1 De Smet, KA et al. (2000) Three pathways for trehalose biosynthesis in mycobacteria. Microbiology (Reading, Engl.) 146 ( Pt 1) 199-208 PubMed GONUTS page
- ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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