MYCTU:KATG

Species (Taxon ID)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332)
Gene Name(s)	katG (ECO:0000255 with HAMAP-Rule:MF_01961)
Protein Name(s)	Catalase-peroxidase (ECO:0000255 with HAMAP-Rule:MF_01961) CP (ECO:0000255 with HAMAP-Rule:MF_01961) Peroxidase/catalase (ECO:0000255 with HAMAP-Rule:MF_01961)
External Links
UniProt	P9WIE5
EMBL	X68081 U06258 U40593 U40595 U41305 U41306 U41307 U41308 U41309 U41310 U41311 U41312 U41313 U41314 JX303265 JX303270 JX303273 JX303276 JX303277 JX303278 JX303280 AL123456 AF002194 L14268
PIR	A70519
RefSeq	NP_216424.1 WP_003899075.1 YP_006515311.1
PDB	1SFZ 1SJ2 2CCA 2CCD 4C50 4C51
PDBsum	1SFZ 1SJ2 2CCA 2CCD 4C50 4C51
ProteinModelPortal	P9WIE5
SMR	P9WIE5
GeneID	13316702 885638
KEGG	mtu:Rv1908c mtv:RVBD_1908c
TubercuList	Rv1908c
KO	K03782
OMA	PAIRATF
PhylomeDB	P9WIE5
Reactome	REACT_121009
Proteomes	UP000001584
GO	GO:0005618 GO:0005829 GO:0005576 GO:0005886 GO:0004096 GO:0020037 GO:0046872 GO:0070404 GO:0070402 GO:0016677 GO:0004601 GO:0042744 GO:0046677 GO:0006979
HAMAP	MF_01961
InterPro	IPR000763 IPR010255 IPR002016 IPR019794 IPR019793
Pfam	PF00141
PRINTS	PR00460 PR00458
SUPFAM	SSF48113
TIGRFAMs	TIGR00198
PROSITE	PS00435 PS00436 PS50873

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0070404	NADH binding	PMID:9006925^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070402	NADPH binding	PMID:9006925^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	PMID:11795785^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	PMID:9395452^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:15231843^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:9006925^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0016677	oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor	PMID:10080924^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:9864198^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11967065^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	PMID:9006925^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004096	catalase activity	PMID:11795785^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004096	catalase activity	PMID:9395452^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004096	catalase activity	PMID:9006925^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15525680^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14532352^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:15525680^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005618	cell wall	PMID:20825248^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:17443846^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	PMID:10463167^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:C3SY12	P	Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10511 PANTHER:PTN000777458	P	Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10511 PANTHER:PTN000777458 UniProtKB:P9WIE5	P	Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10511 PANTHER:PTN000777458 UniProtKB:P9WIE5	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10511 PANTHER:PTN000777458 UniProtKB:P9WIE5	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000777458 UniProtKB:P9WIE5 UniProtKB:Q96VT4	C	Seeded From UniProt	complete
enables	GO:0004096	catalase activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10511 PANTHER:PTN000777458 UniProtKB:P9WIE5 UniProtKB:Q7Z7W6 UniProtKB:Q96VT4	F	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004096	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004601	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004096	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004096	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004096	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004096	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004096	P	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004601	P	Seeded From UniProt	complete
enables	GO:0004096	catalase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000763	F	Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000763 InterPro:IPR002016 InterPro:IPR010255 InterPro:IPR019794	F	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000763 InterPro:IPR002016 InterPro:IPR010255	P	Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000763 InterPro:IPR002016 InterPro:IPR010255	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000763 InterPro:IPR002016 InterPro:IPR010255 InterPro:IPR019794	P	Seeded From UniProt	complete
enables	GO:0004096	catalase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000089066	F	Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000089066	F	Seeded From UniProt	complete
involved_in	GO:0052059	evasion or tolerance by symbiont of host-produced reactive oxygen species	Reactome:R-HSA-1222387	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-1222704	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0046	P	Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P	Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0376	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0575	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Johnsson, K et al. (1997) Overexpression, purification, and characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis. J. Biol. Chem. 272 2834-40 PubMed GONUTS page
↑ ^2.0 ^2.1 Zhang, Z et al. (2002) Direct voltammetry and catalysis with Mycobacterium tuberculosis catalase-peroxidase, peroxidases, and catalase in lipid films. Anal. Chem. 74 163-70 PubMed GONUTS page
↑ ^3.0 ^3.1 Nagy, JM et al. (1997) Purification and characterization of recombinant catalase-peroxidase, which confers isoniazid sensitivity in Mycobacterium tuberculosis. J. Biol. Chem. 272 31265-71 PubMed GONUTS page
↑ Bertrand, T et al. (2004) Crystal structure of Mycobacterium tuberculosis catalase-peroxidase. J. Biol. Chem. 279 38991-9 PubMed GONUTS page
↑ Wengenack, NL et al. (1999) Mycobacterium tuberculosis KatG is a peroxynitritase. Biochem. Biophys. Res. Commun. 256 485-7 PubMed GONUTS page
↑ Manca, C et al. (1999) Mycobacterium tuberculosis catalase and peroxidase activities and resistance to oxidative killing in human monocytes in vitro. Infect. Immun. 67 74-9 PubMed GONUTS page
↑ Banu, S et al. (2002) Are the PE-PGRS proteins of Mycobacterium tuberculosis variable surface antigens? Mol. Microbiol. 44 9-19 PubMed GONUTS page
↑ ^8.0 ^8.1 Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
↑ Gu, S et al. (2003) Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol. Cell Proteomics 2 1284-96 PubMed GONUTS page
↑ Wolfe, LM et al. (2010) Proteomic definition of the cell wall of Mycobacterium tuberculosis. J. Proteome Res. 9 5816-26 PubMed GONUTS page
↑ Målen, H et al. (2007) Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. Proteomics 7 1702-18 PubMed GONUTS page
↑ Mulder, MA et al. (1999) Involvement of the N- and C-terminal domains of Mycobacterium tuberculosis KatG in the protection of mutant Escherichia coli against DNA-damaging agents. Microbiology (Reading, Engl.) 145 ( Pt 8) 2011-21 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9006925-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Johnsson, K et al. (1997) Overexpression, purification, and characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis. J. Biol. Chem. 272 2834-40 PubMed GONUTS page

[PMID:11795785-2] 2.0 ^2.1 Zhang, Z et al. (2002) Direct voltammetry and catalysis with Mycobacterium tuberculosis catalase-peroxidase, peroxidases, and catalase in lipid films. Anal. Chem. 74 163-70 PubMed GONUTS page

[PMID:9395452-3] 3.0 ^3.1 Nagy, JM et al. (1997) Purification and characterization of recombinant catalase-peroxidase, which confers isoniazid sensitivity in Mycobacterium tuberculosis. J. Biol. Chem. 272 31265-71 PubMed GONUTS page

[PMID:15231843-4] Bertrand, T et al. (2004) Crystal structure of Mycobacterium tuberculosis catalase-peroxidase. J. Biol. Chem. 279 38991-9 PubMed GONUTS page

[PMID:10080924-5] Wengenack, NL et al. (1999) Mycobacterium tuberculosis KatG is a peroxynitritase. Biochem. Biophys. Res. Commun. 256 485-7 PubMed GONUTS page

[PMID:9864198-6] Manca, C et al. (1999) Mycobacterium tuberculosis catalase and peroxidase activities and resistance to oxidative killing in human monocytes in vitro. Infect. Immun. 67 74-9 PubMed GONUTS page

[PMID:11967065-7] Banu, S et al. (2002) Are the PE-PGRS proteins of Mycobacterium tuberculosis variable surface antigens? Mol. Microbiol. 44 9-19 PubMed GONUTS page

[PMID:15525680-8] 8.0 ^8.1 Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page

[PMID:14532352-9] Gu, S et al. (2003) Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol. Cell Proteomics 2 1284-96 PubMed GONUTS page

[PMID:20825248-10] Wolfe, LM et al. (2010) Proteomic definition of the cell wall of Mycobacterium tuberculosis. J. Proteome Res. 9 5816-26 PubMed GONUTS page

[PMID:17443846-11] Målen, H et al. (2007) Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. Proteomics 7 1702-18 PubMed GONUTS page

[PMID:10463167-12] Mulder, MA et al. (1999) Involvement of the N- and C-terminal domains of Mycobacterium tuberculosis KatG in the protection of mutant Escherichia coli against DNA-damaging agents. Microbiology (Reading, Engl.) 145 ( Pt 8) 2011-21 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MYCTU:KATG

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