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MYCTU:GRPE

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Species (Taxon ID) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332)
Gene Name(s) grpE (ECO:0000255 with HAMAP-Rule:MF_01151)
Protein Name(s) Protein GrpE (ECO:0000255 with HAMAP-Rule:MF_01151)

HSP-70 cofactor (ECO:0000255 with HAMAP-Rule:MF_01151)

External Links
UniProt P9WMT5
EMBL X58406
AL123456
PIR H70574
RefSeq NP_214865.1
YP_006513677.1
ProteinModelPortal P9WMT5
SMR P9WMT5
GeneID 13318218
886497
KEGG mtu:Rv0351
mtv:RVBD_0351
TubercuList Rv0351
KO K03687
OMA ESDDNAG
PhylomeDB P9WMT5
Proteomes UP000001584
GO GO:0005618
GO:0005737
GO:0000774
GO:0009267
GO:0040007
GO:0006457
Gene3D 2.30.22.10
3.90.20.20
HAMAP MF_01151
InterPro IPR000740
IPR013805
IPR009012
PANTHER PTHR21237
Pfam PF01025
PRINTS PR00773
SUPFAM SSF51064
PROSITE PS01071

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

NOT

GO:0008077

Hsp70/Hsp90 organizing protein activity

PMID:23867667[1]

ECO:0000314

F

Figure 6: The mean absorbance significantly varied (P ≤ 0.05) among the groups. Group 1 (rOmp32 alone) had significantly lower antibody titre (P ≤ 0.05) as compared to both groups 2 (rOmp31 with rMTB-Hsp70) and 3 (rOmp31 with FIA). Further, group 3 had significantly higher antibody titre (P ≤ 0.05) as compared to group 2

complete
CACAO 8871

part_of

GO:0005618

cell wall

PMID:20825248[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009267

cellular response to starvation

PMID:11929527[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051082

unfolded protein binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1334416
PANTHER:PTN000478264
UniProtKB:Q9HAV7

F

Seeded From UniProt

complete

enables

GO:0000774

adenyl-nucleotide exchange factor activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10416
PANTHER:PTN000478264
SGD:S000005758

F

Seeded From UniProt

complete

involved_in

GO:0050790

regulation of catalytic activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0000774

P

Seeded From UniProt

complete

involved_in

GO:0050790

regulation of catalytic activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0000774

P

Seeded From UniProt

complete

enables

GO:0000774

adenyl-nucleotide exchange factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000740

F

Seeded From UniProt

complete

involved_in

GO:0006457

protein folding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000740
InterPro:IPR009012

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000740

F

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000740

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000164509

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Dhakal, J et al. () Over-expression of gene encoding heat shock protein 70 from Mycobacterium tuberculosis and its evaluation as vaccine adjuvant. Indian J Med Microbiol 31 123-9 PubMed GONUTS page
  2. Wolfe, LM et al. (2010) Proteomic definition of the cell wall of Mycobacterium tuberculosis. J. Proteome Res. 9 5816-26 PubMed GONUTS page
  3. Betts, JC et al. (2002) Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol. Microbiol. 43 717-31 PubMed GONUTS page
  4. 4.0 4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page