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MYCTU:GLND

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Species (Taxon ID) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332)
Gene Name(s) glnD (ECO:0000255 with HAMAP-Rule:MF_00277)
Protein Name(s) Bifunctional uridylyltransferase/uridylyl-removing enzyme (ECO:0000255 with HAMAP-Rule:MF_00277)

UTase/UR (ECO:0000255 with HAMAP-Rule:MF_00277) Bifunctional [protein-PII] modification enzyme (ECO:0000255 with HAMAP-Rule:MF_00277) Bifunctional nitrogen sensor protein (ECO:0000255 with HAMAP-Rule:MF_00277) [Protein-PII] uridylyltransferase (ECO:0000255 with HAMAP-Rule:MF_00277) PII uridylyltransferase (ECO:0000255 with HAMAP-Rule:MF_00277) UTase (ECO:0000255 with HAMAP-Rule:MF_00277) [Protein-PII]-UMP uridylyl-removing enzyme (ECO:0000255 with HAMAP-Rule:MF_00277) UR (ECO:0000255 with HAMAP-Rule:MF_00277)

External Links
UniProt P9WN29
EMBL AL123456
PIR F70747
RefSeq NP_217434.1
YP_006516371.1
ProteinModelPortal P9WN29
GeneID 13317711
888621
KEGG mtu:Rv2918c
mtv:RVBD_2918c
TubercuList Rv2918c
KO K00990
OMA ELREPWP
PhylomeDB P9WN29
Proteomes UP000001584
GO GO:0005618
GO:0005886
GO:0008773
GO:0016597
GO:0008081
GO:0006807
GO:0006808
Gene3D 1.10.3210.10
HAMAP MF_00277
InterPro IPR002912
IPR010043
IPR003607
IPR006674
IPR013546
Pfam PF01842
PF08335
PF01966
PIRSF PIRSF006288
SMART SM00471
TIGRFAMs TIGR01693
PROSITE PS51671

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008773

(protein-PII) uridylyltransferase activity

PMID:17303474[1]

ECO:0000315

F

Figure 4 shows the effect of a deletion of glnD on total GS activity of the mutant grown in ammonia or glutamate.

complete
CACAO 3474

GO:0070566

adenylyltransferase activity

PMID:23352854[2]

ECO:0000315

F

glnD deletion mutant was unable to adenylylate GlnK, while it was adenylylated in the wild type strain (Suppl. Figure S2).

complete
CACAO 9075

enables

GO:0008773

[protein-PII] uridylyltransferase activity

PMID:17303474[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0070566

adenylyltransferase activity

PMID:23352854[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15525680[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

PMID:15525680[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006807

nitrogen compound metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010043

P

Seeded From UniProt

complete

enables

GO:0008773

[protein-PII] uridylyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010043

F

Seeded From UniProt

complete

enables

GO:0016779

nucleotidyltransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013546

F

Seeded From UniProt

complete

enables

GO:0008773

[protein-PII] uridylyltransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.7.59

F

Seeded From UniProt

complete

enables

GO:0008773

[protein-PII] uridylyltransferase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000035352

F

Seeded From UniProt

complete

involved_in

GO:0006808

regulation of nitrogen utilization

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000035352

P

Seeded From UniProt

complete

enables

GO:0008081

phosphoric diester hydrolase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000035352

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016779

nucleotidyltransferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0548

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Read, R et al. (2007) The role of GlnD in ammonia assimilation in Mycobacterium tuberculosis. Tuberculosis (Edinb) 87 384-90 PubMed GONUTS page
  2. 2.0 2.1 Williams, KJ et al. (2013) Adenylylation of mycobacterial Glnk (PII) protein is induced by nitrogen limitation. Tuberculosis (Edinb) 93 198-206 PubMed GONUTS page
  3. 3.0 3.1 Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page