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MYCTU:FPRA

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Species (Taxon ID) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332)
Gene Name(s) fprA
Protein Name(s) NADPH-ferredoxin reductase FprA

NFR

External Links
UniProt P9WIQ3
EMBL AL123456
PIR A70920
RefSeq NP_217622.1
YP_006516569.1
PDB 1LQT
1LQU
2C7G
PDBsum 1LQT
1LQU
2C7G
ProteinModelPortal P9WIQ3
SMR P9WIQ3
GeneID 13317913
888839
KEGG mtu:Rv3106
mtv:RVBD_3106
TubercuList Rv3106
KO K00528
OMA NAHPNFE
PhylomeDB P9WIQ3
Proteomes UP000001584
GO GO:0005618
GO:0008860
GO:0004324
GO:0050660
GO:0070401
GO:0055114
Gene3D 3.40.50.720
InterPro IPR021163
IPR016040
PIRSF PIRSF000362

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005618

cell wall

PMID:20825248[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0070401

NADP+ binding

PMID:12102623[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

PMID:12071965[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050660

flavin adenine dinucleotide binding

PMID:12071965[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0004324

ferredoxin-NADP+ reductase activity

PMID:12071965[3]

ECO:0000314

F

complete

enables

GO:0008860

ferredoxin-NAD+ reductase activity

PMID:12614197[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004324

ferredoxin-NADP+ reductase activity

PMID:12071965[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0008860

ferredoxin-NAD+ reductase activity

PMID:12614197[4]

ECO:0000314

F

complete

enables

GO:0016491

oxidoreductase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000234102
UniProtKB:Q74FU5

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021163
InterPro:IPR023753

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR021163
InterPro:IPR023753

P

Seeded From UniProt

complete

enables

GO:0004324

ferredoxin-NADP+ reductase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.18.1.2

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Wolfe, LM et al. (2010) Proteomic definition of the cell wall of Mycobacterium tuberculosis. J. Proteome Res. 9 5816-26 PubMed GONUTS page
  2. Bossi, RT et al. (2002) A covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase. Biochemistry 41 8807-18 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Fischer, F et al. (2002) Mycobacterium tuberculosis FprA, a novel bacterial NADPH-ferredoxin reductase. Eur. J. Biochem. 269 3005-13 PubMed GONUTS page
  4. 4.0 4.1 McLean, KJ et al. (2003) Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA. Biochem. J. 372 317-27 PubMed GONUTS page
  5. Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page