GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

MYCTU:ESXB

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332)
Gene Name(s) esxB (synonyms: cfp10, lhp, mtsA10)
Protein Name(s) ESAT-6-like protein EsxB

10 kDa culture filtrate antigen CFP-10 Secreted antigenic protein MTSA-10

External Links
UniProt P9WNK5
EMBL AF004671
AF419854
AL123456
PIR H70802
RefSeq NP_218391.1
WP_003399940.1
PDB 3FAV
PDBsum 3FAV
ProteinModelPortal P9WNK5
SMR P9WNK5
IntAct P9WNK5
STRING 83332.Rv3874
PaxDb P9WNK5
EnsemblBacteria CCP46703
GeneID 886194
KEGG mtu:Rv3874
TubercuList Rv3874
OMA SANIHTS
Proteomes UP000001584
GO GO:0005618
GO:0005576
GO:0005886
GO:0046812
GO:0009405
GO:0044315
InterPro IPR010310
Pfam PF06013
SUPFAM SSF140453
TIGRFAMs TIGR03930

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030593

neutrophil chemotaxis

PMID:25332123[1]

ECO:0000314

P

Figure 3 (A)Cells migrated more with higher concentration CFP-10.

complete
CACAO 11309

GO:0033864

positive regulation of NAD(P)H oxidase activity

PMID:25332123[1]

ECO:0000314

P

Figure 3 (B)Addition of CFP-10 stimulated neutrophils to produce more O2.

complete
CACAO 11310

part_of

GO:0005886

plasma membrane

PMID:15525680[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:14532352[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

PMID:20825248[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

PMID:15525680[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:17443846[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046812

host cell surface binding

PMID:15973432[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0044315

protein secretion by the type VII secretion system

PMID:14756778[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

PMID:14756778[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:9846755[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0044764

multi-organism cellular process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0046812

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0134
UniProtKB-SubCell:SL-0041

C

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0843

P

Seeded From UniProt

complete

part_of

GO:0044165

host cell endoplasmic reticulum

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1038
UniProtKB-SubCell:SL-0388

C

Seeded From UniProt

complete

part_of

GO:0044228

host cell surface

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0378

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Welin, A et al. (2015) CFP-10 from Mycobacterium tuberculosis selectively activates human neutrophils through a pertussis toxin-sensitive chemotactic receptor. Infect. Immun. 83 205-13 PubMed GONUTS page
  2. 2.0 2.1 Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
  3. Gu, S et al. (2003) Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol. Cell Proteomics 2 1284-96 PubMed GONUTS page
  4. Wolfe, LM et al. (2010) Proteomic definition of the cell wall of Mycobacterium tuberculosis. J. Proteome Res. 9 5816-26 PubMed GONUTS page
  5. Målen, H et al. (2007) Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. Proteomics 7 1702-18 PubMed GONUTS page
  6. Renshaw, PS et al. (2005) Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6. EMBO J. 24 2491-8 PubMed GONUTS page
  7. 7.0 7.1 Guinn, KM et al. (2004) Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis. Mol. Microbiol. 51 359-70 PubMed GONUTS page
  8. Berthet, FX et al. (1998) A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10). Microbiology (Reading, Engl.) 144 ( Pt 11) 3195-203 PubMed GONUTS page