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MYCTU:ESXB
Contents
| Species (Taxon ID) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332) | |
| Gene Name(s) | esxB (synonyms: cfp10, lhp, mtsA10) | |
| Protein Name(s) | ESAT-6-like protein EsxB
10 kDa culture filtrate antigen CFP-10 Secreted antigenic protein MTSA-10 | |
| External Links | ||
| UniProt | P9WNK5 | |
| EMBL | AF004671 AF419854 AL123456 | |
| PIR | H70802 | |
| RefSeq | NP_218391.1 WP_003399940.1 | |
| PDB | 3FAV | |
| PDBsum | 3FAV | |
| ProteinModelPortal | P9WNK5 | |
| SMR | P9WNK5 | |
| IntAct | P9WNK5 | |
| STRING | 83332.Rv3874 | |
| PaxDb | P9WNK5 | |
| EnsemblBacteria | CCP46703 | |
| GeneID | 886194 | |
| KEGG | mtu:Rv3874 | |
| TubercuList | Rv3874 | |
| OMA | SANIHTS | |
| Proteomes | UP000001584 | |
| GO | GO:0005618 GO:0005576 GO:0005886 GO:0046812 GO:0009405 GO:0044315 | |
| InterPro | IPR010310 | |
| Pfam | PF06013 | |
| SUPFAM | SSF140453 | |
| TIGRFAMs | TIGR03930 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0030593 |
neutrophil chemotaxis |
ECO:0000314 |
P |
Figure 3 (A)Cells migrated more with higher concentration CFP-10. |
complete | |||||
| GO:0033864 |
positive regulation of NAD(P)H oxidase activity |
ECO:0000314 |
P |
Figure 3 (B)Addition of CFP-10 stimulated neutrophils to produce more O2. |
complete | |||||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005618 |
cell wall |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005618 |
cell wall |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046812 |
host cell surface binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044315 |
protein secretion by the type VII secretion system |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0044764 |
multi-organism cellular process |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046812 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005618 |
cell wall |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044165 |
host cell endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044228 |
host cell surface |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Welin, A et al. (2015) CFP-10 from Mycobacterium tuberculosis selectively activates human neutrophils through a pertussis toxin-sensitive chemotactic receptor. Infect. Immun. 83 205-13 PubMed GONUTS page
- ↑ 2.0 2.1 Mawuenyega, KG et al. (2005) Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol. Biol. Cell 16 396-404 PubMed GONUTS page
- ↑ Gu, S et al. (2003) Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol. Cell Proteomics 2 1284-96 PubMed GONUTS page
- ↑ Wolfe, LM et al. (2010) Proteomic definition of the cell wall of Mycobacterium tuberculosis. J. Proteome Res. 9 5816-26 PubMed GONUTS page
- ↑ Målen, H et al. (2007) Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. Proteomics 7 1702-18 PubMed GONUTS page
- ↑ Renshaw, PS et al. (2005) Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6. EMBO J. 24 2491-8 PubMed GONUTS page
- ↑ 7.0 7.1 Guinn, KM et al. (2004) Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis. Mol. Microbiol. 51 359-70 PubMed GONUTS page
- ↑ Berthet, FX et al. (1998) A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10). Microbiology (Reading, Engl.) 144 ( Pt 11) 3195-203 PubMed GONUTS page
