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MYCTU:CP125
Contents
| Species (Taxon ID) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332) | |
| Gene Name(s) | cyp125 | |
| Protein Name(s) | Steroid C26-monooxygenase
Cholest-4-en-3-one 26-monooxygenase Cytochrome P450 125 Steroid C27-monooxygenase | |
| External Links | ||
| UniProt | P9WPP1 | |
| EMBL | AL123456 | |
| PIR | B70677 | |
| RefSeq | NP_218062.1 YP_006517034.1 | |
| PDB | 2X5L 2X5W 2XC3 2XN8 3IVY 3IW0 3IW1 3IW2 | |
| PDBsum | 2X5L 2X5W 2XC3 2XN8 3IVY 3IW0 3IW1 3IW2 | |
| ProteinModelPortal | P9WPP1 | |
| SMR | P9WPP1 | |
| BindingDB | P9WPP1 | |
| ChEMBL | CHEMBL5629 | |
| GeneID | 13317153 887782 | |
| KEGG | mtu:Rv3545c mtv:RVBD_3545c | |
| TubercuList | Rv3545c | |
| KO | K15981 | |
| OMA | QVDYTGK | |
| PhylomeDB | P9WPP1 | |
| Proteomes | UP000001584 | |
| GO | GO:0036199 GO:0020037 GO:0005506 GO:0008395 GO:0006707 GO:0044117 | |
| Gene3D | 1.10.630.10 | |
| InterPro | IPR001128 IPR002397 | |
| Pfam | PF00067 | |
| PRINTS | PR00359 | |
| SUPFAM | SSF48264 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0044117 |
growth of symbiont in host |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036199 |
cholest-4-en-3-one 26-monooxygenase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0020037 |
heme binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008395 |
steroid hydroxylase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006707 |
cholesterol catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006707 |
cholesterol catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006707 |
cholesterol catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036199 |
cholest-4-en-3-one 26-monooxygenase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001209364 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008395 |
steroid hydroxylase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001209364 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006707 |
cholesterol catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001209364 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005506 |
iron ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0020037 |
heme binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004497 |
monooxygenase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008202 |
steroid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008203 |
cholesterol metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016042 |
lipid catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006707 |
cholesterol catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA01058 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Rengarajan, J et al. (2005) Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc. Natl. Acad. Sci. U.S.A. 102 8327-32 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Ouellet, H et al. (2010) Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one. Mol. Microbiol. 77 730-42 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Capyk, JK et al. (2009) Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids. J. Biol. Chem. 284 35534-42 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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