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MYCTE:A0A0H3LG06
Contents
| Species (Taxon ID) | Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman). (652616) | |
| Gene Name(s) | esxA (ECO:0000313 with EMBL:BAL68013.1) | |
| Protein Name(s) | ESAT-6-like protein (ECO:0000256 with RuleBase:RU362001) | |
| External Links | ||
| UniProt | A0A0H3LG06 | |
| EMBL | AP012340 | |
| RefSeq | WP_003399963.1 | |
| ProteinModelPortal | A0A0H3LG06 | |
| KEGG | mtn:ERDMAN_4249 | |
| KO | K14956 | |
| Proteomes | UP000007568 | |
| InterPro | IPR010310 | |
| Pfam | PF06013 | |
| SUPFAM | SSF140453 | |
| TIGRFAMs | TIGR03930 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:1902714 |
negative regulation of interferon-gamma secretion |
ECO:0000314 |
P |
Figure 2 |
complete | |||||
| GO:0032700 |
negative regulation of interleukin-17 production |
ECO:0000314 |
P |
Figure 4 (D) |
complete | |||||
| GO:1904468 |
negative regulation of tumor necrosis factor secretion |
ECO:0000314 |
P |
Figure 4 (E) |
complete | |||||
| GO:0050868 |
negative regulation of T cell activation |
ECO:0000314 |
P |
Figure 7 |
complete | |||||
|
involved_in |
GO:0044315 |
protein secretion by the type VII secretion system |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0052083 |
negative regulation by symbiont of host cell-mediated immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0052027 |
modulation by symbiont of host signal transduction pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Wang, X et al. (2009) ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells. J. Immunol. 182 3668-77 PubMed GONUTS page
- ↑ Champion, PA et al. (2006) C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis. Science 313 1632-6 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Stanley, SA et al. (2003) Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system. Proc. Natl. Acad. Sci. U.S.A. 100 13001-6 PubMed GONUTS page
