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MYCS2:PAT
Contents
| Species (Taxon ID) | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155). (246196) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Acetyltransferase Pat
GCN5-related N-acetyltransferase GNAT Protein acetyltransferase Pat | |
| External Links | ||
| UniProt | A0R3F9 | |
| EMBL | CP000480 CP001663 | |
| RefSeq | YP_006570045.1 YP_889697.1 | |
| PDB | 4OLL 4ONU 4ORF | |
| PDBsum | 4OLL 4ONU 4ORF | |
| ProteinModelPortal | A0R3F9 | |
| STRING | 246196.MSMEG_5458 | |
| EnsemblBacteria | ABK70370 AFP41750 | |
| GeneID | 4534401 | |
| KEGG | msm:MSMEG_5458 | |
| PATRIC | 18083185 | |
| eggNOG | COG0664 | |
| HOGENOM | HOG000053442 | |
| OMA | AEIAFIV | |
| OrthoDB | EOG6GTZM5 | |
| BioCyc | MSME246196:GJ4Y-5457-MONOMER | |
| Proteomes | UP000000757 UP000006158 | |
| GO | GO:0005952 GO:0008603 GO:0046872 GO:0008080 | |
| Gene3D | 2.60.120.10 3.40.630.30 | |
| InterPro | IPR016181 IPR002373 IPR018490 IPR018488 IPR000595 IPR000182 IPR014710 | |
| Pfam | PF13302 PF00027 | |
| PRINTS | PR00103 | |
| SMART | SM00100 | |
| SUPFAM | SSF51206 SSF55729 | |
| PROSITE | PS00889 PS50042 PS51186 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008080 |
N-acetyltransferase activity |
ECO:0000314 |
F |
Figure 6 shows that this particular GMAT protein acts as a protein acetyltransferase and specifically acetylates the ε-amino group of a highly conserved lysine residue in acetyl-CoA synthetase . This acetylation results in the inactivation of ACS activity. Lysine acetylation by MsPat is dependent on 3',5'-cyclic adenosine monophosphate (cAMP), an important second messenger, indicating that MsPat is a downstream target of the intracellular cAMP signaling pathway |
complete | |||||
|
enables |
GO:0008080 |
N-acetyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016746 |
transferase activity, transferring acyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Xu, H et al. (2011) Reversible acetylation and inactivation of Mycobacterium tuberculosis acetyl-CoA synthetase is dependent on cAMP. Biochemistry 50 5883-92 PubMed GONUTS page
