MYCS2:A0QNG2

Species (Taxon ID)	Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155). (246196)
Gene Name(s)	pknA (ECO:0000313 with EMBL:ABK75101.1)
Protein Name(s)	Serine/threonine protein kinase PknA (ECO:0000313 with EMBL:ABK75101.1) Serine/threonine-protein kinases pknA (ECO:0000313 with EMBL:AFP36515.1)
External Links
UniProt	A0QNG2
EMBL	CP000480 CP001663
RefSeq	WP_011726617.1 YP_884450.1
STRING	246196.MSMEG_0030
EnsemblBacteria	ABK75101 AFP36515
GeneID	4531207
KEGG	msb:LJ00_00150 msg:MSMEI_0032 msm:MSMEG_0030
PATRIC	18072528
eggNOG	ENOG4107TPY COG0515
HOGENOM	HOG000037187
KO	K12132
OMA	FVERFRI
OrthoDB	POG091H0264
Proteomes	UP000000757 UP000006158
GO	GO:0016021 GO:0005524 GO:0004674
InterPro	IPR011009 IPR000719 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0044117	growth of symbiont in host	PMID:25713147	ECO:0000315			P		In Mycobacterium smegmatis mc2 155, strain mc(2)ΔpknA strain was transformed with pNit vector, pNit-PknA or pNit-PknAK42M. When the inducer was absent the mc(2)ΔpknA:pNit-PknA grew robustly which indicated wild type PknA was capable of functional complementation. Fig 6C shows the growth of M. smegmatis when transformed and showed that PknA is significant for cell growth. When the PknA kinase activity was absent, seen in Fig 6C with pNit vextor and kinase inactive PknA(K42M), there was no growth recovery. Fig 6E and F demonstrated that PknA is necessary for growth. Depletion of PknA in the mc(2)ΔpknA strain resulted in compromised growth, show in Fig 2B.	complete CACAO 12496
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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References

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