MOUSE:WLS

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Wls (synonyms: Gpr177)
Protein Name(s)	Protein wntless homolog Integral membrane protein GPR177 Protein evenness interrupted homolog EVI
External Links
UniProt	Q6DID7
EMBL	AK019886 AK029053 AK029104 AK044810 AK049842 AK077407 AK159207 BC075615 BC018381
CCDS	CCDS38684.1
RefSeq	NP_080858.3 XP_006502027.1
UniGene	Mm.6766
ProteinModelPortal	Q6DID7
DIP	DIP-49004N
IntAct	Q6DID7
PhosphoSite	Q6DID7
MaxQB	Q6DID7
PaxDb	Q6DID7
PRIDE	Q6DID7
Ensembl	ENSMUST00000068952
GeneID	68151
KEGG	mmu:68151
UCSC	uc008rwc.1
CTD	79971
MGI	MGI:1915401
eggNOG	NOG77798
GeneTree	ENSGT00390000005897
HOGENOM	HOG000039226
HOVERGEN	HBG055794
InParanoid	Q6DID7
OMA	INIRLPV
OrthoDB	EOG7B05CP
PhylomeDB	Q6DID7
TreeFam	TF105975
Reactome	REACT_213918
ChiTaRS	Wls
NextBio	326538
PRO	PR:Q6DID7
Proteomes	UP000000589
Bgee	Q6DID7
CleanEx	MM_GPR177
Genevestigator	Q6DID7
GO	GO:0031410 GO:0030659 GO:0032839 GO:0032590 GO:0005794 GO:0000139 GO:0016021 GO:0017147 GO:0009948 GO:0001707 GO:0090263 GO:0016055
InterPro	IPR009551
PANTHER	PTHR13449

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0022002	negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway	PMID:21226062^[1]	ECO:0000315			P		Figure 4- By inactivating gene Gpr177, neural development guided by the Wnt receptor is distorted and made abnormal.	complete
involved_in	GO:0030901	midbrain development	PMID:20614471^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030902	hindbrain development	PMID:20614471^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000033)	Seeded From UniProt	complete
involved_in	GO:0031017	exocrine pancreas development	PMID:20614471^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:20614471^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000033)	Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	PMID:16678096^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95ST2	P		Seeded From UniProt	complete
involved_in	GO:0061357	positive regulation of Wnt protein secretion	PMID:16678096^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q95ST2	P	part_of:(GO:0030177)	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:19841259^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:19841259^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:19841259^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009948	anterior/posterior axis specification	PMID:19841259^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:19841259^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	PMID:19841259^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061355	Wnt protein secretion	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036141 PANTHER:PTN001003029 UniProtKB:Q5T9L3	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036141 MGI:MGI:1915401 PANTHER:PTN001003029 UniProtKB:Q5T9L3	F		Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001003029 UniProtKB:Q5T9L3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5T9L3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061357	positive regulation of Wnt protein secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5T9L3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061355	Wnt protein secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5T9L3	P		Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735139	C		Seeded From UniProt	complete
part_of	GO:0032590	dendrite membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735139	C		Seeded From UniProt	complete
enables	GO:0031852	mu-type opioid receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735139	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5T9L3	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030177	positive regulation of Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5T9L3	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5T9L3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006886	intracellular protein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5T9L3	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5T9L3	C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5T9L3	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5T9L3	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5T9L3	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5T9L3	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q5T9L3	C		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5T9L3 ensembl:ENSP00000346829	P		Seeded From UniProt	complete
involved_in	GO:0061357	positive regulation of Wnt protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5T9L3 ensembl:ENSP00000346829	P		Seeded From UniProt	complete
involved_in	GO:0061355	Wnt protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5T9L3 ensembl:ENSP00000346829	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5T9L3 ensembl:ENSP00000346829	C		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5T9L3 ensembl:ENSP00000346829	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5T9L3 ensembl:ENSP00000346829	F		Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5T9L3 ensembl:ENSP00000346829	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5T9L3 ensembl:ENSP00000346829	C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5T9L3 ensembl:ENSP00000346829	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5T9L3 ensembl:ENSP00000346829	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5T9L3 ensembl:ENSP00000346829	C		Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P689 ensembl:ENSRNOP00000052120	C		Seeded From UniProt	complete
part_of	GO:0032590	dendrite membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P689 ensembl:ENSRNOP00000052120	C		Seeded From UniProt	complete
enables	GO:0031852	mu-type opioid receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P689 ensembl:ENSRNOP00000052120	F		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009551	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009551	F		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ () PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Carpenter, AC et al. (2010) Generation of mice with a conditional null allele for Wntless. Genesis 48 554-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Bartscherer, K et al. (2006) Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 125 523-33 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Fu, J et al. (2009) Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc. Natl. Acad. Sci. U.S.A. 106 18598-603 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21226062-1] () PubMed GONUTS page

[PMID:20614471-2] 2.0 ^2.1 ^2.2 ^2.3 Carpenter, AC et al. (2010) Generation of mice with a conditional null allele for Wntless. Genesis 48 554-8 PubMed GONUTS page

[PMID:16678096-3] 3.0 ^3.1 Bartscherer, K et al. (2006) Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 125 523-33 PubMed GONUTS page

[PMID:19841259-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Fu, J et al. (2009) Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc. Natl. Acad. Sci. U.S.A. 106 18598-603 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:WLS

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Annotations

Notes

References

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