MOUSE:WFS1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Wfs1
Protein Name(s)	Wolframin
External Links
UniProt	P56695
EMBL	AJ011971 AF084482
CCDS	CCDS19245.1
RefSeq	NP_035846.1
UniGene	Mm.20916
ProteinModelPortal	P56695
SMR	P56695
BioGrid	204558
PhosphoSite	P56695
MaxQB	P56695
PaxDb	P56695
PRIDE	P56695
Ensembl	ENSMUST00000043964
GeneID	22393
KEGG	mmu:22393
UCSC	uc008xff.1
CTD	7466
MGI	MGI:1328355
eggNOG	NOG82472
HOGENOM	HOG000132944
HOVERGEN	HBG014957
InParanoid	P56695
KO	K14020
OMA	GWNHLEP
OrthoDB	EOG7F24S4
PhylomeDB	P56695
TreeFam	TF326849
Reactome	REACT_106572
ChiTaRS	Wfs1
NextBio	302771
PRO	PR:P56695
Proteomes	UP000000589
Bgee	P56695
CleanEx	MM_WFS1
ExpressionAtlas	P56695
Genevestigator	P56695
GO	GO:0030425 GO:0005783 GO:0030176 GO:0033613 GO:0051117 GO:0005215 GO:0031625 GO:0055074 GO:0032469 GO:0030968 GO:0030433 GO:0042593 GO:0001822 GO:1902236 GO:0043524 GO:0043069 GO:0043433 GO:2000675 GO:0050877 GO:0042048 GO:0070845 GO:0051928 GO:0045927 GO:0051247 GO:0031398 GO:0045862 GO:0050821 GO:0051726 GO:0003091 GO:0034976 GO:0007605 GO:0007601
InterPro	IPR026208 IPR026209
PANTHER	PTHR13098
PRINTS	PR02060 PR02061

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	PMID:16571599^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	PMID:16087305^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	PMID:16571599^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055074	calcium ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
involved_in	GO:0051928	positive regulation of calcium ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	PMID:16571599^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	PMID:17947299^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050877	nervous system process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:20160352^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	stabilizes:(UniProtKB:Q9DBY1)	Seeded From UniProt	complete
involved_in	GO:0045927	positive regulation of growth	PMID:19293327^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
involved_in	GO:0043069	negative regulation of programmed cell death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:15994758^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:20160352^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:F6VAN0)	Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:16571599^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030433	ubiquitin-dependent ERAD pathway	PMID:20160352^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:F6VAN0)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9JLT5	C		Seeded From UniProt	complete
part_of	GO:0030176	integral component of endoplasmic reticulum membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O76024	C		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	PMID:18613120^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:16087305^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0003091	renal water homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903892	negative regulation of ATF6-mediated unfolded protein response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903892	negative regulation of ATF6-mediated unfolded protein response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68954	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055074	calcium ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051928	positive regulation of calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050877	nervous system process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68954	P		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68954	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68954	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043069	negative regulation of programmed cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68954	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032469	endoplasmic reticulum calcium ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68954	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030433	ubiquitin-dependent ERAD pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68954	C		Seeded From UniProt	complete
part_of	GO:0030176	integral component of endoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007601	visual perception	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68954	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003091	renal water homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
colocalizes_with	GO:0000502	proteasome complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68954	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O76024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:68954	P		Seeded From UniProt	complete
involved_in	GO:1903892	negative regulation of ATF6-mediated unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PT53 ensembl:ENSRNOP00000032218	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PT53 ensembl:ENSRNOP00000032218	P		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PT53 ensembl:ENSRNOP00000032218	F		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PT53 ensembl:ENSRNOP00000032218	P		Seeded From UniProt	complete
involved_in	GO:0042048	olfactory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PT53 ensembl:ENSRNOP00000032218	P		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PT53 ensembl:ENSRNOP00000032218	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PT53 ensembl:ENSRNOP00000032218	F		Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PT53 ensembl:ENSRNOP00000032218	P		Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PT53 ensembl:ENSRNOP00000032218	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PT53 ensembl:ENSRNOP00000032218	F		Seeded From UniProt	complete
part_of	GO:0000502	proteasome complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PT53 ensembl:ENSRNOP00000032218	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PT53 ensembl:ENSRNOP00000032218	P		Seeded From UniProt	complete
involved_in	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:1903892	negative regulation of ATF6-mediated unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0055074	calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0051928	positive regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0051247	positive regulation of protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	F		Seeded From UniProt	complete
involved_in	GO:0050877	nervous system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0043069	negative regulation of programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	F		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0030433	ubiquitin-dependent ERAD pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
part_of	GO:0030176	integral component of endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	C		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0003091	renal water homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O76024 ensembl:ENSP00000226760	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026208	C		Seeded From UniProt	complete
involved_in	GO:0055074	calcium ion homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026208	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Yamada, T et al. (2006) WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells. Hum. Mol. Genet. 15 1600-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Philbrook, C et al. () Expressional and functional studies of Wolframin, the gene function deficient in Wolfram syndrome, in mice and patient cells. Exp. Gerontol. 40 671-8 PubMed GONUTS page
↑ Zatyka, M et al. (2008) Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress. Hum. Mol. Genet. 17 190-200 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Fonseca, SG et al. (2010) Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J. Clin. Invest. 120 744-55 PubMed GONUTS page
↑ Kõks, S et al. (2009) Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway. Physiol. Genomics 37 249-59 PubMed GONUTS page
↑ Ueda, K et al. (2005) Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic beta-cells via transcriptional activation. Eur. J. Endocrinol. 153 167-76 PubMed GONUTS page
↑ Kawano, J et al. (2008) Wolfram syndrome 1 (Wfs1) gene expression in the normal mouse visual system. J. Comp. Neurol. 510 1-23 PubMed GONUTS page

[PMID:16571599-1] 1.0 ^1.1 ^1.2 ^1.3 Yamada, T et al. (2006) WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells. Hum. Mol. Genet. 15 1600-9 PubMed GONUTS page

[PMID:16087305-2] 2.0 ^2.1 Philbrook, C et al. () Expressional and functional studies of Wolframin, the gene function deficient in Wolfram syndrome, in mice and patient cells. Exp. Gerontol. 40 671-8 PubMed GONUTS page

[PMID:17947299-3] Zatyka, M et al. (2008) Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress. Hum. Mol. Genet. 17 190-200 PubMed GONUTS page

[PMID:20160352-4] 4.0 ^4.1 ^4.2 Fonseca, SG et al. (2010) Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J. Clin. Invest. 120 744-55 PubMed GONUTS page

[PMID:19293327-5] Kõks, S et al. (2009) Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway. Physiol. Genomics 37 249-59 PubMed GONUTS page

[PMID:15994758-6] Ueda, K et al. (2005) Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic beta-cells via transcriptional activation. Eur. J. Endocrinol. 153 167-76 PubMed GONUTS page

[PMID:18613120-7] Kawano, J et al. (2008) Wolfram syndrome 1 (Wfs1) gene expression in the normal mouse visual system. J. Comp. Neurol. 510 1-23 PubMed GONUTS page

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MOUSE:WFS1

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