MOUSE:VWF

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Vwf (ECO:0000312 with MGI:MGI:98941)
Protein Name(s)	von Willebrand factor vWF von Willebrand antigen 2 von Willebrand antigen II
External Links
UniProt	Q8CIZ8
EMBL	AY208897 AY162409 AF539800 AK083237 AJ238390 U27810
CCDS	CCDS20552.1
RefSeq	NP_035838.3
UniGene	Mm.22339
PDB	1U0O
PDBsum	1U0O
ProteinModelPortal	Q8CIZ8
SMR	Q8CIZ8
IntAct	Q8CIZ8
MINT	MINT-4140177
MEROPS	I08.950
PhosphoSite	Q8CIZ8
MaxQB	Q8CIZ8
PaxDb	Q8CIZ8
PRIDE	Q8CIZ8
Ensembl	ENSMUST00000001995
GeneID	22371
KEGG	mmu:22371
CTD	7450
MGI	MGI:98941
eggNOG	NOG12793
GeneTree	ENSGT00760000118896
HOGENOM	HOG000169747
HOVERGEN	HBG004380
InParanoid	Q8CIZ8
KO	K03900
PhylomeDB	Q8CIZ8
Reactome	REACT_216309 REACT_225107 REACT_239392 REACT_240371 REACT_245546 REACT_246176
EvolutionaryTrace	Q8CIZ8
NextBio	302707
PRO	PR:Q8CIZ8
Proteomes	UP000000589
Bgee	Q8CIZ8
CleanEx	MM_VWF
ExpressionAtlas	Q8CIZ8
Genevestigator	Q8CIZ8
GO	GO:0005783 GO:0009897 GO:0031012 GO:0005576 GO:0005578 GO:0033093 GO:0051087 GO:0005518 GO:0001948 GO:0019865 GO:0005178 GO:0002020 GO:0042803 GO:0047485 GO:0007596 GO:0007155 GO:0031589 GO:0007599 GO:0001889 GO:0001890 GO:0030168 GO:0051260
Gene3D	3.40.50.410
InterPro	IPR006207 IPR002919 IPR014853 IPR012011 IPR002035 IPR001007 IPR001846
PANTHER	PTHR11339:SF259
Pfam	PF08742 PF01826 PF00092 PF00093 PF00094
SMART	SM00832 SM00041 SM00327 SM00214 SM00216
SUPFAM	SSF53300 SSF57567
PROSITE	PS01185 PS01225 PS50234 PS01208 PS50184 PS51233

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28071719^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0000006)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:28071719^[1]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0000006)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:22159717^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002048)\|part_of:(UBERON:0001155)	Seeded From UniProt	complete
enables	GO:0005201	extracellular matrix structural constituent	PMID:22159717^[2]	ECO:0007666	automatically integrated combinatorial computational and experimental evidence used in manual assertion		F	occurs_in:(UBERON:0002048)\|occurs_in:(UBERON:0001155)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:24006456^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
part_of	GO:0033093	Weibel-Palade body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	C		Seeded From UniProt	complete
involved_in	GO:0031589	cell-substrate adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	C		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	P		Seeded From UniProt	complete
enables	GO:0019865	immunoglobulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
involved_in	GO:0007599	hemostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	C		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621759	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
part_of	GO:0033093	Weibel-Palade body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031589	cell-substrate adhesion	PMID:11071623^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153009	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031589	cell-substrate adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030168	platelet activation	PMID:21037087^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153009	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030168	platelet activation	PMID:10930441^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153009	P		Seeded From UniProt	complete
NOT\|acts_upstream_of_or_within	GO:0030168	platelet activation	PMID:17380206^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153009	P		Seeded From UniProt	complete
enables	GO:0019865	immunoglobulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:8562500^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000233)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007599	hemostasis	PMID:9689113^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153009	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007599	hemostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007596	blood coagulation	PMID:9689113^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153009	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007596	blood coagulation	PMID:21037087^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153009	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007596	blood coagulation	PMID:17380206^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2153009	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007596	blood coagulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007596	blood coagulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621759	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621759	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621759	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621759	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04275	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001890	placenta development	PMID:7854452^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857656	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001889	liver development	PMID:7854452^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857656	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007599	hemostasis	PMID:11212329^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0094	P		Seeded From UniProt	complete
involved_in	GO:0007599	hemostasis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0356	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page
↑ ^2.0 ^2.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page
↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
↑ André, P et al. (2000) Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins. Blood 96 3322-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Cosemans, JM et al. (2011) Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow. Blood 117 651-60 PubMed GONUTS page
↑ Ni, H et al. (2000) Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J. Clin. Invest. 106 385-92 PubMed GONUTS page
↑ ^7.0 ^7.1 Dubois, C et al. (2007) Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model. J. Clin. Invest. 117 953-60 PubMed GONUTS page
↑ Aigner, S et al. (1995) Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin. Int. Immunol. 7 1557-65 PubMed GONUTS page
↑ ^9.0 ^9.1 Denis, C et al. (1998) A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc. Natl. Acad. Sci. U.S.A. 95 9524-9 PubMed GONUTS page
↑ ^10.0 ^10.1 Schmidt, C et al. (1995) Scatter factor/hepatocyte growth factor is essential for liver development. Nature 373 699-702 PubMed GONUTS page
↑ Denis, CV & Wagner, DD (1999) Insights from von Willebrand disease animal models. Cell. Mol. Life Sci. 56 977-90 PubMed GONUTS page

[PMID:28071719-1] 1.0 ^1.1 Naba, A et al. (2017) Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep 7 40495 PubMed GONUTS page

[PMID:22159717-2] 2.0 ^2.1 Naba, A et al. (2012) The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Mol. Cell Proteomics 11 M111.014647 PubMed GONUTS page

[PMID:24006456-3] Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page

[PMID:11071623-4] André, P et al. (2000) Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins. Blood 96 3322-8 PubMed GONUTS page

[PMID:21037087-5] 5.0 ^5.1 Cosemans, JM et al. (2011) Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow. Blood 117 651-60 PubMed GONUTS page

[PMID:10930441-6] Ni, H et al. (2000) Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J. Clin. Invest. 106 385-92 PubMed GONUTS page

[PMID:17380206-7] 7.0 ^7.1 Dubois, C et al. (2007) Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model. J. Clin. Invest. 117 953-60 PubMed GONUTS page

[PMID:8562500-8] Aigner, S et al. (1995) Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin. Int. Immunol. 7 1557-65 PubMed GONUTS page

[PMID:9689113-9] 9.0 ^9.1 Denis, C et al. (1998) A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc. Natl. Acad. Sci. U.S.A. 95 9524-9 PubMed GONUTS page

[PMID:7854452-10] 10.0 ^10.1 Schmidt, C et al. (1995) Scatter factor/hepatocyte growth factor is essential for liver development. Nature 373 699-702 PubMed GONUTS page

[PMID:11212329-11] Denis, CV & Wagner, DD (1999) Insights from von Willebrand disease animal models. Cell. Mol. Life Sci. 56 977-90 PubMed GONUTS page

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MOUSE:VWF

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