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MOUSE:TUSC2
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Tusc2 (synonyms: Fus1, Lgcc, Pdap2) | |
| Protein Name(s) | Tumor suppressor candidate 2
Fusion 1 protein Fus-1 protein PDGFA-associated protein 2 | |
| External Links | ||
| UniProt | Q9WVF8 | |
| EMBL | AF123387 BC048477 | |
| CCDS | CCDS23495.1 | |
| RefSeq | NP_062716.1 | |
| UniGene | Mm.21739 | |
| ProteinModelPortal | Q9WVF8 | |
| PhosphoSite | Q9WVF8 | |
| MaxQB | Q9WVF8 | |
| PaxDb | Q9WVF8 | |
| PRIDE | Q9WVF8 | |
| Ensembl | ENSMUST00000010198 | |
| GeneID | 80385 | |
| KEGG | mmu:80385 | |
| UCSC | uc009rls.1 | |
| CTD | 11334 | |
| MGI | MGI:1931086 | |
| eggNOG | NOG71519 | |
| GeneTree | ENSGT00390000008040 | |
| HOGENOM | HOG000007342 | |
| HOVERGEN | HBG054202 | |
| InParanoid | Q9WVF8 | |
| OMA | TRRGSMY | |
| OrthoDB | EOG7TBC4J | |
| PhylomeDB | Q9WVF8 | |
| TreeFam | TF314634 | |
| NextBio | 350029 | |
| PRO | PR:Q9WVF8 | |
| Proteomes | UP000000589 | |
| Bgee | Q9WVF8 | |
| CleanEx | MM_TUSC2 | |
| ExpressionAtlas | Q9WVF8 | |
| Genevestigator | Q9WVF8 | |
| GO | GO:0005739 GO:0048469 GO:0071609 GO:0050829 GO:0006954 GO:0032618 GO:0001779 GO:0032700 GO:0070945 GO:0006909 GO:0032733 GO:0051881 GO:2000377 GO:0052567 | |
| InterPro | IPR029393 | |
| PANTHER | PTHR15453 | |
| Pfam | PF15000 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
acts_upstream_of_or_within |
GO:2000377 |
regulation of reactive oxygen species metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3706236 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0071609 |
chemokine (C-C motif) ligand 5 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3706236 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0070945 |
neutrophil mediated killing of gram-negative bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3706236 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0052567 |
response to defense-related host reactive oxygen species production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3706236 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051881 |
regulation of mitochondrial membrane potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3706236 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0051881 |
regulation of mitochondrial membrane potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3706236 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0050829 |
defense response to Gram-negative bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3706236 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048469 |
cell maturation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:103014 |
P |
results_in_maturation_of:(CL:0000623) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0048469 |
cell maturation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3706236 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0032733 |
positive regulation of interleukin-10 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3706236 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032700 |
negative regulation of interleukin-17 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3706236 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032618 |
interleukin-15 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3706236 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006954 |
inflammatory response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3706236 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006909 |
phagocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3706236 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003674 |
molecular_function |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001779 |
natural killer cell differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:103014 |
P |
results_in_acquisition_of_features_of:(CL:0000623) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0001779 |
natural killer cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3706236 |
P |
|
Seeded From UniProt |
complete | |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Uzhachenko, R et al. (2012) Tumour suppressor Fus1 provides a molecular link between inflammatory response and mitochondrial homeostasis. J. Pathol. 227 456-69 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Hood, MI et al. (2013) Loss of mitochondrial protein Fus1 augments host resistance to Acinetobacter baumannii infection. Infect. Immun. 81 4461-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Ivanova, AV et al. (2007) Autoimmunity, spontaneous tumourigenesis, and IL-15 insufficiency in mice with a targeted disruption of the tumour suppressor gene Fus1. J. Pathol. 211 591-601 PubMed GONUTS page
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