MOUSE:TRPV6

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Trpv6
Protein Name(s)	Transient receptor potential cation channel subfamily V member 6 TrpV6 Calcium transport protein 1 CaT1 Epithelial calcium channel 2 ECaC2
External Links
UniProt	Q91WD2
EMBL	AJ542487 AK077234 BC016101
CCDS	CCDS20052.1
PIR	JC7796
RefSeq	NP_071858.2
UniGene	Mm.296889
PDB	2RFA
PDBsum	2RFA
ProteinModelPortal	Q91WD2
SMR	Q91WD2
GuidetoPHARMACOLOGY	512
PhosphoSite	Q91WD2
PaxDb	Q91WD2
PRIDE	Q91WD2
Ensembl	ENSMUST00000031902
GeneID	64177
KEGG	mmu:64177
UCSC	uc009bqc.2
CTD	55503
MGI	MGI:1927259
eggNOG	NOG278734
GeneTree	ENSGT00550000074425
HOGENOM	HOG000234397
HOVERGEN	HBG061442
InParanoid	Q91WD2
KO	K04975
OMA	RQESWAQ
OrthoDB	EOG70087C
PhylomeDB	Q91WD2
TreeFam	TF314711
Reactome	REACT_227861
EvolutionaryTrace	Q91WD2
NextBio	319950
PRO	PR:Q91WD2
Proteomes	UP000000589
Bgee	Q91WD2
ExpressionAtlas	Q91WD2
Genevestigator	Q91WD2
GO	GO:0070062 GO:0016021 GO:0005886 GO:0005262 GO:0006816
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683 IPR005821 IPR004729 IPR008344 IPR008345
Pfam	PF12796 PF00520
PRINTS	PR01415 PR01765 PR01766
SMART	SM00248
SUPFAM	SSF48403
TIGRFAMs	TIGR00870
PROSITE	PS50297 PS50088

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R186	C	Seeded From UniProt	complete
involved_in	GO:0098703	calcium ion import across plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R186	P	Seeded From UniProt	complete
involved_in	GO:0098703	calcium ion import across plasma membrane	PMID:22878123^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	PMID:22878123^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055074	calcium ion homeostasis	PMID:22878123^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H1D0	F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H1D0	C	Seeded From UniProt	complete
involved_in	GO:0098703	calcium ion import across plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H1D0	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9H1D0	C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000061616 RGD:628841 RGD:69335 UniProtKB:Q9H1D0 UniProtKB:Q9NQA5	C	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341787 MGI:MGI:1341836 MGI:MGI:1926945 MGI:MGI:1927259 MGI:MGI:2429764 PANTHER:PTN000832860 RGD:620636 RGD:69335 RGD:69337 SGD:S000005613 UniProtKB:F1RIT1 UniProtKB:Q9H1D0 UniProtKB:Q9HBA0 UniProtKB:Q9NQA5 WB:WBGene00003889	F	Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341787 MGI:MGI:2181407 PANTHER:PTN000061616	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098703	calcium ion import across plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H1D0	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098703	calcium ion import across plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69335	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070588	calcium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H1D0	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070588	calcium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69335	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070509	calcium ion import	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69335	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055074	calcium ion homeostasis	PMID:17129178^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3778644	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051289	protein homotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69335	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69335	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035898	parathyroid hormone secretion	PMID:17129178^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3778644	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:12077127^[4]	ECO:0000250	sequence similarity evidence used in manual assertion		C	Seeded From UniProt	Missing: with/from
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:12077127^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H1D0	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H1D0	C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69335	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H1D0	C	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H1D0	F	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:12077127^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9H1D0	F	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69335	F	Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821 InterPro:IPR024862	F	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008344 InterPro:IPR008345	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821 InterPro:IPR024862	P	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008344 InterPro:IPR008345	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008344 InterPro:IPR008345 InterPro:IPR024862	C	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Woudenberg-Vrenken, TE et al. (2012) Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption. Am. J. Physiol. Gastrointest. Liver Physiol. 303 G879-85 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Bianco, SD et al. (2007) Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J. Bone Miner. Res. 22 274-85 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Nilius, B et al. (2002) Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3. J. Biol. Chem. 277 30852-8 PubMed GONUTS page

[PMID:22878123-1] 1.0 ^1.1 ^1.2 Woudenberg-Vrenken, TE et al. (2012) Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption. Am. J. Physiol. Gastrointest. Liver Physiol. 303 G879-85 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17129178-3] 3.0 ^3.1 Bianco, SD et al. (2007) Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J. Bone Miner. Res. 22 274-85 PubMed GONUTS page

[PMID:12077127-4] 4.0 ^4.1 ^4.2 Nilius, B et al. (2002) Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3. J. Biol. Chem. 277 30852-8 PubMed GONUTS page

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MOUSE:TRPV6

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