MOUSE:TOM22

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tomm22 (synonyms: Tom22)
Protein Name(s)	Mitochondrial import receptor subunit TOM22 homolog Translocase of outer membrane 22 kDa subunit homolog
External Links
UniProt	Q9CPQ3
EMBL	AK008133 AK009868 AK013471 AK049442 AK150360 AK152843 AK167803 BC056920
CCDS	CCDS27646.1
RefSeq	NP_766197.2
UniGene	Mm.246435 Mm.485795
ProteinModelPortal	Q9CPQ3
SMR	Q9CPQ3
BioGrid	230178
IntAct	Q9CPQ3
MINT	MINT-1844683
STRING	10090.ENSMUSP00000023062
iPTMnet	Q9CPQ3
PhosphoSitePlus	Q9CPQ3
EPD	Q9CPQ3
MaxQB	Q9CPQ3
PaxDb	Q9CPQ3
PeptideAtlas	Q9CPQ3
PRIDE	Q9CPQ3
TopDownProteomics	Q9CPQ3
Ensembl	ENSMUST00000023062
GeneID	223696
KEGG	mmu:223696
UCSC	uc007wud.1
CTD	56993
MGI	MGI:2450248
eggNOG	KOG4111 ENOG41122K3
GeneTree	ENSGT00390000016475
HOGENOM	HOG000067816
HOVERGEN	HBG061819
InParanoid	Q9CPQ3
KO	K17769
OMA	FYTFSCN
OrthoDB	EOG091G0XN1
PhylomeDB	Q9CPQ3
TreeFam	TF106201
Reactome	[www.reactome.org/content/detail/R-MMU-5205685 R-MMU-5205685]
PRO	PR:Q9CPQ3
Proteomes	UP000000589
Bgee	ENSMUSG00000022427
Genevisible	Q9CPQ3
GO	GO:0016021 GO:0031307 GO:0016020 GO:0005743 GO:0005742 GO:0005739 GO:0008320 GO:0030150 GO:0045040
InterPro	IPR005683
PANTHER	PTHR12504:SF3
Pfam	PF04281

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005741	mitochondrial outer membrane	PMID:21245132^[1]	ECO:0000314			C	As seen on figure 6, localization of TOM22 is to the outer mitochondrial membrane (OMM). Mitochondrial import receptor subunit TOM22 Mouse	complete CACAO 12796
involved_in	GO:0006626	protein targeting to mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q75Q41	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051204	protein insertion into mitochondrial membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1303260	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045040	protein insertion into mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NS69	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1303260	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NS69	C	Seeded From UniProt	complete
enables	GO:0008320	protein transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1303260	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006626	protein targeting to mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1303260	P	Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:12865426^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005742	mitochondrial outer membrane translocase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NS69	C	Seeded From UniProt	complete
part_of	GO:0005742	mitochondrial outer membrane translocase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1303260	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NS69	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1303260	C	Seeded From UniProt	complete
involved_in	GO:0071806	protein transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008320	P	Seeded From UniProt	complete
involved_in	GO:0071806	protein transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008320	P	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q549C5 ensembl:ENSP00000216034	C	Seeded From UniProt	complete
involved_in	GO:0051204	protein insertion into mitochondrial membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q75Q41 ensembl:ENSRNOP00000019323	P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q75Q41 ensembl:ENSRNOP00000019323	P	Seeded From UniProt	complete
enables	GO:0008320	protein transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q75Q41 ensembl:ENSRNOP00000019323	F	Seeded From UniProt	complete
involved_in	GO:0006626	protein targeting to mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q75Q41 ensembl:ENSRNOP00000019323	P	Seeded From UniProt	complete
part_of	GO:0005742	mitochondrial outer membrane translocase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q75Q41 ensembl:ENSRNOP00000019323	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q75Q41 ensembl:ENSRNOP00000019323	C	Seeded From UniProt	complete
involved_in	GO:0045040	protein insertion into mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NS69 ensembl:ENSP00000216034	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NS69 ensembl:ENSP00000216034	C	Seeded From UniProt	complete
part_of	GO:0005742	mitochondrial outer membrane translocase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NS69 ensembl:ENSP00000216034	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NS69 ensembl:ENSP00000216034	C	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005683	C	Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005683	P	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653 UniProtKB-KW:KW-0811	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Safdar, A et al. (2011) Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis. J. Biol. Chem. 286 10605-17 PubMed GONUTS page
↑ Da Cruz, S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J. Biol. Chem. 278 41566-71 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:21245132-1] Safdar, A et al. (2011) Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis. J. Biol. Chem. 286 10605-17 PubMed GONUTS page

[PMID:12865426-2] Da Cruz, S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J. Biol. Chem. 278 41566-71 PubMed GONUTS page

[PMID:18614015-3] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

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MOUSE:TOM22

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