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MOUSE:TDRD1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Tdrd1
Protein Name(s) Tudor domain-containing protein 1
External Links
UniProt Q99MV1
EMBL AB067571
AB183526
AB183527
AB183528
AB183529
AK029806
AF285591
BC129954
BC129955
CCDS CCDS29922.1
RefSeq NP_001002238.1
NP_001002240.1
NP_001002241.1
NP_113564.2
UniGene Mm.247541
PDB 4B9W
4B9X
PDBsum 4B9W
4B9X
ProteinModelPortal Q99MV1
SMR Q99MV1
BioGrid 219947
DIP DIP-48523N
IntAct Q99MV1
STRING 10090.ENSMUSP00000107233
PhosphoSite Q99MV1
PaxDb Q99MV1
PRIDE Q99MV1
Ensembl ENSMUST00000078723
ENSMUST00000111604
ENSMUST00000111606
ENSMUST00000121249
GeneID 83561
KEGG mmu:83561
UCSC uc008hzi.1
CTD 56165
MGI MGI:1933218
eggNOG NOG267246
GeneTree ENSGT00730000110295
HOGENOM HOG000081819
HOVERGEN HBG108555
InParanoid Q99MV1
KO K18405
OMA AIKCVLA
OrthoDB EOG7VX8VC
PhylomeDB Q99MV1
ChiTaRS Tdrd1
NextBio 350650
PRO PR:Q99MV1
Proteomes UP000000589
Bgee Q99MV1
CleanEx MM_TDRD1
Genevestigator Q99MV1
GO GO:0033391
GO:0005737
GO:0043186
GO:0071546
GO:0030529
GO:0046872
GO:0043046
GO:0031047
GO:0007281
GO:0051321
GO:0007275
GO:0034587
GO:0007283
InterPro IPR002999
IPR002893
Pfam PF00567
PF01753
SMART SM00333
PROSITE PS50304
PS01360
PS50865

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005515

protein binding

PMID:22996915[1]

ECO:0000315

F

Figure 1B

complete
CACAO 5156

part_of

GO:0043186

P granule

PMID:20439430[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0071546

pi-body

PMID:19861488[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0071546

pi-body

PMID:20059948[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0071546

pi-body

PMID:20011505[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043186

P granule

PMID:17038506[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043186

P granule

PMID:19465913[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043046

DNA methylation involved in gamete generation

PMID:19465913[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034587

piRNA metabolic process

PMID:19465913[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031047

gene silencing by RNA

PMID:19465913[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

PMID:17038506[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

PMID:19465913[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007281

germ cell development

PMID:17038506[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

PMID:17141210[8]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:17972)

Seeded From UniProt

complete

part_of

GO:0033391

chromatoid body

PMID:17141210[8]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000039)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:17141210[8]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000039)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:14550528[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-MMU-5629217
Reactome:R-MMU-5606252
Reactome:R-MMU-5606226
Reactome:R-MMU-5605349
Reactome:R-MMU-5605279
Reactome:R-MMU-5605213
Reactome:R-MMU-5605205

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

involved_in

GO:0031047

gene silencing by RNA

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0943

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

involved_in

GO:0051321

meiotic cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0469

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0744

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Mathioudakis, N et al. (2012) The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors. RNA 18 2056-72 PubMed GONUTS page
  2. ↑ Kuramochi-Miyagawa, S et al. (2010) MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev. 24 887-92 PubMed GONUTS page
  3. ↑ Yamaji, M et al. (2010) Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3. Reproduction 139 381-93 PubMed GONUTS page
  4. ↑ Shoji, M et al. (2009) The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev. Cell 17 775-87 PubMed GONUTS page
  5. ↑ Aravin, AA et al. (2009) Cytoplasmic compartmentalization of the fetal piRNA pathway in mice. PLoS Genet. 5 e1000764 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Chuma, S et al. (2006) Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice. Proc. Natl. Acad. Sci. U.S.A. 103 15894-9 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 Reuter, M et al. (2009) Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile. Nat. Struct. Mol. Biol. 16 639-46 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Hosokawa, M et al. (2007) Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice. Dev. Biol. 301 38-52 PubMed GONUTS page
  9. ↑ Chuma, S et al. (2003) Mouse Tudor Repeat-1 (MTR-1) is a novel component of chromatoid bodies/nuages in male germ cells and forms a complex with snRNPs. Mech. Dev. 120 979-90 PubMed GONUTS page
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