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MOUSE:SYNJ2
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Synj2 (synonyms: Kiaa0348) | |
| Protein Name(s) | Synaptojanin-2
Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2 | |
| External Links | ||
| UniProt | Q9D2G5 | |
| EMBL | AF041857 AF041858 AF041859 AF041860 AF041861 AF041862 AK129122 AK019694 BC058749 BC060214 AF026123 | |
| CCDS | CCDS28365.1 CCDS49932.1 | |
| PIR | JW0105 PW0050 PW0051 | |
| RefSeq | NP_001106822.1 NP_001106823.1 NP_001106824.1 NP_001277627.1 NP_035653.2 XP_006523268.1 | |
| UniGene | Mm.236068 | |
| ProteinModelPortal | Q9D2G5 | |
| SMR | Q9D2G5 | |
| IntAct | Q9D2G5 | |
| PhosphoSite | Q9D2G5 | |
| MaxQB | Q9D2G5 | |
| PaxDb | Q9D2G5 | |
| PRIDE | Q9D2G5 | |
| Ensembl | ENSMUST00000061091 ENSMUST00000080283 ENSMUST00000115784 ENSMUST00000115789 | |
| GeneID | 20975 | |
| KEGG | mmu:20975 | |
| UCSC | uc008afm.2 uc008afp.2 uc008afu.1 uc012ajh.1 | |
| CTD | 8871 | |
| MGI | MGI:1201671 | |
| eggNOG | COG5411 | |
| GeneTree | ENSGT00760000119075 | |
| HOVERGEN | HBG079225 | |
| InParanoid | Q9D2G5 | |
| KO | K01099 | |
| PhylomeDB | Q9D2G5 | |
| TreeFam | TF354311 | |
| Reactome | REACT_198973 | |
| ChiTaRS | Synj2 | |
| NextBio | 299956 | |
| PRO | PR:Q9D2G5 | |
| Proteomes | UP000000589 | |
| Bgee | Q9D2G5 | |
| CleanEx | MM_SYNJ2 | |
| ExpressionAtlas | Q9D2G5 | |
| Genevestigator | Q9D2G5 | |
| GO | GO:0005737 GO:0016020 GO:0000166 GO:0004439 GO:0003723 GO:0046856 | |
| Gene3D | 3.30.70.330 3.60.10.10 | |
| InterPro | IPR015047 IPR005135 IPR000300 IPR012677 IPR000504 IPR002013 | |
| Pfam | PF08952 PF03372 PF02383 | |
| SMART | SM00128 | |
| SUPFAM | SSF56219 | |
| PROSITE | PS50102 PS50275 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0090102 |
cochlea development |
ECO:0000315 |
P |
Fig 1. A gradual loss of inner and outer hair cells was detected in 8 and 12 week old mutant mice, starting in the basal turn of the cochlea and spreading towards the apical region, leading to a collapse of the Organ of Corti. At the same time there was a reduction in the number of spiral ganglia cells and the remaining cells showed increased vacuolation. |
complete | |||||
|
part_of |
GO:0098793 |
presynapse |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001675099 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001675099 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046856 |
phosphatidylinositol dephosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0023508 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046855 |
inositol phosphate dephosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1354961 |
P |
Seeded From UniProt |
complete | ||
|
NOT|enables |
GO:0030165 |
PDZ domain binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000878543 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017124 |
SH3 domain binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000878542 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007420 |
brain development |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001675099 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004439 |
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103257 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0098793 |
presynapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69436 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0052744 |
phosphatidylinositol monophosphate phosphatase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69436 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69436 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048312 |
intracellular distribution of mitochondria |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69436 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0046856 |
phosphatidylinositol dephosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69436 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0046855 |
inositol phosphate dephosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69436 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043679 |
axon terminus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69436 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032587 |
ruffle membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69436 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031315 |
extrinsic component of mitochondrial outer membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69436 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017124 |
SH3 domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69436 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005881 |
cytoplasmic microtubule |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69436 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69436 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004445 |
inositol-polyphosphate 5-phosphatase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69436 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004439 |
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034595 |
phosphatidylinositol phosphate 5-phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042578 |
phosphoric ester hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046856 |
phosphatidylinositol dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004439 |
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030424 |
axon |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Manji, SS et al. (2011) A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart. PLoS ONE 6 e17607 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Khvotchev, M & Südhof, TC (1998) Developmentally regulated alternative splicing in a novel synaptojanin. J. Biol. Chem. 273 2306-11 PubMed GONUTS page
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- GO:0030165 ! PDZ domain binding
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0052744 ! phosphatidylinositol monophosphate phosphatase activity
- GO:0004439 ! phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
- GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity
- GO:0046856 ! phosphatidylinositol dephosphorylation
- GO:0042578 ! phosphoric ester hydrolase activity
- GO:0005886 ! plasma membrane
- GO:0098793 ! presynapse
