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MOUSE:STML2
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Stoml2 (synonyms: Slp2) | |
| Protein Name(s) | Stomatin-like protein 2, mitochondrial
SLP-2 mslp2 | |
| External Links | ||
| UniProt | Q99JB2 | |
| EMBL | AF323178 AK002793 BC003425 BC069941 | |
| CCDS | CCDS18089.1 | |
| RefSeq | NP_075720.1 | |
| UniGene | Mm.331565 | |
| ProteinModelPortal | Q99JB2 | |
| SMR | Q99JB2 | |
| BioGrid | 211578 | |
| IntAct | Q99JB2 | |
| STRING | 10090.ENSMUSP00000030169 | |
| iPTMnet | Q99JB2 | |
| PhosphoSitePlus | Q99JB2 | |
| REPRODUCTION-2DPAGE | Q99JB2 | |
| EPD | Q99JB2 | |
| MaxQB | Q99JB2 | |
| PaxDb | Q99JB2 | |
| PeptideAtlas | Q99JB2 | |
| PRIDE | Q99JB2 | |
| Ensembl | ENSMUST00000030169 | |
| GeneID | 66592 | |
| KEGG | mmu:66592 | |
| UCSC | uc008soy.1 | |
| CTD | 30968 | |
| MGI | MGI:1913842 | |
| eggNOG | KOG2620 COG0330 | |
| GeneTree | ENSGT00550000074454 | |
| HOGENOM | HOG000217038 | |
| HOVERGEN | HBG061488 | |
| InParanoid | Q99JB2 | |
| OMA | RDQINGQ | |
| OrthoDB | EOG091G0MSB | |
| PhylomeDB | Q99JB2 | |
| TreeFam | TF105750 | |
| Reactome | R-MMU-8949664 | |
| PRO | PR:Q99JB2 | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000028455 | |
| CleanEx | MM_STOML2 | |
| ExpressionAtlas | Q99JB2 | |
| Genevisible | Q99JB2 | |
| GO | GO:0015629 GO:0008180 GO:0019897 GO:0001772 GO:0045121 GO:0005743 GO:0005758 GO:0005739 GO:0042101 GO:1901612 GO:0051020 GO:0035710 GO:0006874 GO:0032623 GO:0010876 GO:0042776 GO:0006851 GO:0034982 GO:0007005 GO:1900210 GO:0090297 GO:0010918 GO:0051259 GO:1990046 GO:0050852 | |
| InterPro | IPR001107 IPR036013 IPR032435 IPR001972 | |
| Pfam | PF01145 PF16200 | |
| PRINTS | PR00721 | |
| SMART | SM00244 | |
| SUPFAM | SSF117892 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:1990046 |
stress-induced mitochondrial fusion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:1901612 |
cardiolipin binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900210 |
positive regulation of cardiolipin metabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090297 |
positive regulation of mitochondrial DNA replication |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|involved_in |
GO:0051646 |
mitochondrion localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051259 |
protein complex oligomerization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050852 |
T cell receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042776 |
mitochondrial ATP synthesis coupled proton transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042776 |
mitochondrial ATP synthesis coupled proton transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0042101 |
T cell receptor complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035710 |
CD4-positive, alpha-beta T cell activation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034982 |
mitochondrial protein processing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032623 |
interleukin-2 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019897 |
extrinsic component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0015629 |
actin cytoskeleton |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010918 |
positive regulation of mitochondrial membrane potential |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010876 |
lipid localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007005 |
mitochondrion organization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006874 |
cellular calcium ion homeostasis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006851 |
mitochondrial calcium ion transmembrane transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005758 |
mitochondrial intermembrane space |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0001772 |
immunological synapse |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:1901612 |
cardiolipin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1900210 |
positive regulation of cardiolipin metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0090297 |
positive regulation of mitochondrial DNA replication |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051259 |
protein complex oligomerization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051020 |
GTPase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0050852 |
T cell receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042776 |
mitochondrial ATP synthesis coupled proton transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0042101 |
T cell receptor complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019897 |
extrinsic component of plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0015629 |
actin cytoskeleton |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010918 |
positive regulation of mitochondrial membrane potential |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0008180 |
COP9 signalosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007005 |
mitochondrion organization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006874 |
cellular calcium ion homeostasis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006851 |
mitochondrial calcium ion transmembrane transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005758 |
mitochondrial intermembrane space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16846)|part_of:(EMAPA:16894)|part_of:(EMAPA:17373)|part_of:(EMAPA:16105) |
Seeded From UniProt |
complete | ||
|
colocalizes_with |
GO:0001772 |
immunological synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007005 |
mitochondrion organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006874 |
cellular calcium ion homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006851 |
mitochondrial calcium ion transmembrane transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005758 |
mitochondrial intermembrane space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0001772 |
immunological synapse |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:1901612 |
cardiolipin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900210 |
positive regulation of cardiolipin metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090297 |
positive regulation of mitochondrial DNA replication |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051259 |
protein complex oligomerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051020 |
GTPase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050852 |
T cell receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042776 |
mitochondrial ATP synthesis coupled proton transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0042101 |
T cell receptor complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0019897 |
extrinsic component of plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0015629 |
actin cytoskeleton |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010918 |
positive regulation of mitochondrial membrane potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0008180 |
COP9 signalosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UJZ1 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005743 |
mitochondrial inner membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005758 |
mitochondrial intermembrane space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045121 |
membrane raft |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Tondera, D et al. (2009) SLP-2 is required for stress-induced mitochondrial hyperfusion. EMBO J. 28 1589-600 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Christie, DA et al. (2012) Mitochondrial and plasma membrane pools of stomatin-like protein 2 coalesce at the immunological synapse during T cell activation. PLoS ONE 7 e37144 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Christie, DA et al. (2012) Stomatin-like protein 2 deficiency in T cells is associated with altered mitochondrial respiration and defective CD4+ T cell responses. J. Immunol. 189 4349-60 PubMed GONUTS page
- ↑ Da Cruz, S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J. Biol. Chem. 278 41566-71 PubMed GONUTS page
- ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
- ↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
c
e
i
m
- Mammalia
- GO:0016020 ! membrane
- GO:0045121 ! membrane raft
- Metazoa
- GO:0006851 ! mitochondrial calcium ion transmembrane transport
- GO:0034982 ! mitochondrial protein processing
- GO:0005743 ! mitochondrial inner membrane
- GO:0005758 ! mitochondrial intermembrane space
- GO:0007005 ! mitochondrion organization
- GO:0005739 ! mitochondrion
- GO:0051646 ! mitochondrion localization
- Muridae
- Murinae
- Muroidea
- Mus
- Mus musculus
- Myomorpha
p
- GO:0005886 ! plasma membrane
- GO:0010918 ! positive regulation of mitochondrial membrane potential
- GO:0090297 ! positive regulation of mitochondrial DNA replication
- GO:1900210 ! positive regulation of cardiolipin metabolic process
- GO:0051259 ! protein complex oligomerization
- GO:0042776 ! proton motive force-driven mitochondrial ATP synthesis
r
