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MOUSE:STAR4

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Stard4
Protein Name(s) StAR-related lipid transfer protein 4

START domain-containing protein 4 StARD4

External Links
UniProt Q99JV5
EMBL AF480298
AF480297
BC005642
CCDS CCDS29123.1
RefSeq NP_598535.1
UniGene Mm.127058
Mm.393277
PDB 1JSS
PDBsum 1JSS
ProteinModelPortal Q99JV5
SMR Q99JV5
PhosphoSite Q99JV5
MaxQB Q99JV5
PaxDb Q99JV5
PRIDE Q99JV5
GeneID 170459
KEGG mmu:170459
CTD 134429
MGI MGI:2156764
eggNOG NOG310389
HOGENOM HOG000137345
HOVERGEN HBG106946
InParanoid Q99JV5
PhylomeDB Q99JV5
EvolutionaryTrace Q99JV5
NextBio 370095
PRO PR:Q99JV5
Proteomes UP000000589
Genevestigator Q99JV5
GO GO:0005739
GO:0015485
GO:0006869
Gene3D 3.30.530.20
InterPro IPR023393
IPR002913
Pfam PF01852
SMART SM00234
PROSITE PS50848

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005783

endoplasmic reticulum

PMID:21767660[1]

ECO:0000314

C

Figure 6B and Figure 6C.

complete
CACAO 8426

GO:0005829

cytosol

PMID:21767660[1]

ECO:0000314

C

Figure 6D.

complete
CACAO 8427

GO:0034435

cholesterol esterification

PMID:21767660[1]

ECO:0000314

P

Figure 8.

complete
CACAO 8428

involved_in

GO:0034435

cholesterol esterification

PMID:21767660[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21767660[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:21767660[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010879

cholesterol transport involved in cholesterol storage

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96DR4

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010873

positive regulation of cholesterol esterification

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96DR4

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070859

positive regulation of bile acid biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96DR4

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070508

cholesterol import

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96DR4

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032367

intracellular cholesterol transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96DR4

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96DR4

C

Seeded From UniProt

complete

enables

GO:0017127

cholesterol transporter activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96DR4

F

Seeded From UniProt

complete

enables

GO:0015485

cholesterol binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q96DR4

F

Seeded From UniProt

complete

enables

GO:0015485

cholesterol binding

PMID:12011453[2]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:Q14849

F

Seeded From UniProt

complete

enables

GO:0015485

cholesterol binding

PMID:12011452[3]

ECO:0000247

sequence alignment evidence used in manual assertion

UniProtKB:P51557

F

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002913

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:12011453[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0446

F

Seeded From UniProt

complete

involved_in

GO:0006869

lipid transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0445

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Rodriguez-Agudo, D et al. (2011) Subcellular localization and regulation of StarD4 protein in macrophages and fibroblasts. Biochim. Biophys. Acta 1811 597-606 PubMed GONUTS page
  2. 2.0 2.1 Romanowski, MJ et al. (2002) Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain. Proc. Natl. Acad. Sci. U.S.A. 99 6949-54 PubMed GONUTS page
  3. Soccio, RE et al. (2002) The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6. Proc. Natl. Acad. Sci. U.S.A. 99 6943-8 PubMed GONUTS page