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MOUSE:SPD2A
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Sh3pxd2a (synonyms: Fish, Sh3md1, Tks5) | |
| Protein Name(s) | SH3 and PX domain-containing protein 2A
Five SH3 domain-containing protein SH3 multiple domains protein 1 Tyrosine kinase substrate with five SH3 domains | |
| External Links | ||
| UniProt | O89032 | |
| EMBL | AJ007012 AC132268 AC132288 BC118022 | |
| CCDS | CCDS29891.1 CCDS50464.1 | |
| RefSeq | NP_001158189.1 NP_032044.2 | |
| UniGene | Mm.127560 | |
| ProteinModelPortal | O89032 | |
| SMR | O89032 | |
| BioGrid | 199678 | |
| IntAct | O89032 | |
| STRING | 10090.ENSMUSP00000080325 | |
| PhosphoSite | O89032 | |
| MaxQB | O89032 | |
| PaxDb | O89032 | |
| PRIDE | O89032 | |
| Ensembl | ENSMUST00000081619 ENSMUST00000111800 | |
| GeneID | 14218 | |
| KEGG | mmu:14218 | |
| UCSC | uc008huy.2 uc008hva.2 | |
| CTD | 9644 | |
| MGI | MGI:1298393 | |
| eggNOG | NOG148927 | |
| GeneTree | ENSGT00530000063010 | |
| HOGENOM | HOG000154376 | |
| HOVERGEN | HBG089589 | |
| InParanoid | O89032 | |
| OMA | LESGWWY | |
| OrthoDB | EOG7H4DSQ | |
| TreeFam | TF329347 | |
| ChiTaRS | Sh3pxd2a | |
| NextBio | 285465 | |
| PRO | PR:O89032 | |
| Proteomes | UP000000589 | |
| Bgee | O89032 | |
| CleanEx | MM_SH3PXD2A | |
| Genevestigator | O89032 | |
| GO | GO:0030054 GO:0042995 GO:0005737 GO:0002102 GO:0035091 GO:0072593 GO:0006801 | |
| Gene3D | 3.30.1520.10 | |
| InterPro | IPR001683 IPR001452 | |
| Pfam | PF00787 PF00018 | |
| SMART | SM00312 SM00326 | |
| SUPFAM | SSF50044 SSF64268 | |
| PROSITE | PS50195 PS50002 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0035091 |
phosphatidylinositol binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043325 |
phosphatidylinositol-3,4-bisphosphate binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005546 |
phosphatidylinositol-4,5-bisphosphate binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0002102 |
podosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0002020 |
protease binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0010314 |
phosphatidylinositol-5-phosphate binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070273 |
phosphatidylinositol-4-phosphate binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0032266 |
phosphatidylinositol-3-phosphate binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072593 |
reactive oxygen species metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0002102 |
podosome |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035091 |
phosphatidylinositol binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001038805 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016176 |
superoxide-generating NADPH oxidase activator activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919143 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006801 |
superoxide metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919143 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0072675 |
osteoclast fusion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006801 |
superoxide metabolic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0002102 |
podosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043085 |
positive regulation of catalytic activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0016176 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0072675 |
osteoclast fusion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5TCZ1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006801 |
superoxide metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5TCZ1 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0002102 |
podosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5TCZ1 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035091 |
phosphatidylinositol binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0002102 |
podosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Abram, CL et al. (2003) The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. J. Biol. Chem. 278 16844-51 PubMed GONUTS page
- ↑ Diaz, B et al. (2009) Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Sci Signal 2 ra53 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
g
p
- GO:0043325 ! phosphatidylinositol-3,4-bisphosphate binding
- GO:0032266 ! phosphatidylinositol-3-phosphate binding
- GO:0070273 ! phosphatidylinositol-4-phosphate binding
- GO:0010314 ! phosphatidylinositol-5-phosphate binding
- GO:0005546 ! phosphatidylinositol-4,5-bisphosphate binding
- GO:0035091 ! phosphatidylinositol binding
- GO:0002102 ! podosome
- GO:0043085 ! positive regulation of catalytic activity
- GO:0002020 ! protease binding
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