MOUSE:SGCD

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sgcd
Protein Name(s)	Delta-sarcoglycan Delta-SG 35 kDa dystrophin-associated glycoprotein 35DAG
External Links
UniProt	P82347
EMBL	AB024923
CCDS	CCDS24584.1
RefSeq	NP_036021.1 XP_006533369.1 XP_006533370.1
UniGene	Mm.338890
ProteinModelPortal	P82347
BioGrid	204865
PhosphoSite	P82347
MaxQB	P82347
PaxDb	P82347
PRIDE	P82347
Ensembl	ENSMUST00000077221
GeneID	24052
KEGG	mmu:24052
UCSC	uc007ioz.1
CTD	6444
MGI	MGI:1346525
eggNOG	NOG318936
HOGENOM	HOG000007853
HOVERGEN	HBG008669
InParanoid	P82347
KO	K12563
OMA	IRSRPGN
PhylomeDB	P82347
TreeFam	TF313538
NextBio	303991
PRO	PR:P82347
Proteomes	UP000000589
Bgee	P82347
ExpressionAtlas	P82347
Genevestigator	P82347
GO	GO:0005737 GO:0005856 GO:0016011 GO:0016010 GO:0005887 GO:0016012 GO:0042383 GO:0048738 GO:0060047 GO:0061024 GO:0055001 GO:0007517
InterPro	IPR006875 IPR027661
PANTHER	PTHR12939:SF6
Pfam	PF04790

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0060047	heart contraction	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025391 PANTHER:PTN000986439	P		Seeded From UniProt	complete
involved_in	GO:0048738	cardiac muscle tissue development	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000986439 ZFIN:ZDB-GENE-030131-3684	P		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346524 MGI:MGI:1346525 PANTHER:PTN000986439	C		Seeded From UniProt	complete
part_of	GO:0016012	sarcoglycan complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346524 MGI:MGI:1346525 MGI:MGI:2388820 PANTHER:PTN000986439	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0086003	cardiac muscle cell contraction	PMID:10481911^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154694	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060977	coronary vasculature morphogenesis	PMID:10481911^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154694	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060048	cardiac muscle contraction	PMID:23695275^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180193	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055074	calcium ion homeostasis	PMID:19931597^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180193	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048739	cardiac muscle fiber development	PMID:23695275^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180193	P		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:16403451^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:10678176^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000188) part_of:(EMAPA:32716)	Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:10481911^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034629	cellular protein-containing complex localization	PMID:17164264^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5911918	P	has_input:(GO:0016012)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034629	cellular protein-containing complex localization	PMID:10481911^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154694	P	has_input:(GO:0016012) occurs_in:(CL:0000192)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019722	calcium-mediated signaling	PMID:19931597^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180193	P		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:19931597^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:16403451^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016012	sarcoglycan complex	PMID:16524571^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016012	sarcoglycan complex	PMID:12189167^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016011	dystroglycan complex	PMID:10678176^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016010	dystrophin-associated glycoprotein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92629	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008219	cell death	PMID:10481911^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154694	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17164264^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16524571^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10481911^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003015	heart process	PMID:23695275^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180193	P		Seeded From UniProt	complete
part_of	GO:0016010	dystrophin-associated glycoprotein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92629 ensembl:ENSP00000338343	C		Seeded From UniProt	complete
part_of	GO:0016012	sarcoglycan complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006875 InterPro:IPR027661 InterPro:IPR039972	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006875 InterPro:IPR027661 InterPro:IPR039972	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061024	membrane organization	PMID:12189167^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:10448073^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0238	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Coral-Vazquez, R et al. (1999) Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy. Cell 98 465-74 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Rutschow, D et al. (2014) S151A δ-sarcoglycan mutation causes a mild phenotype of cardiomyopathy in mice. Eur. J. Hum. Genet. 22 119-25 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Solares-Pérez, A et al. (2010) Intracellular Ca2+ transients in delta-sarcoglycan knockout mouse skeletal muscle. Biochim. Biophys. Acta 1800 373-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Estrada, FJ et al. (2006) A novel isoform of delta-sarcoglycan is localized at the sarcoplasmic reticulum of mouse skeletal muscle. Biochem. Biophys. Res. Commun. 340 865-71 PubMed GONUTS page
↑ ^6.0 ^6.1 Durbeej, M et al. (2000) Disruption of the beta-sarcoglycan gene reveals pathogenetic complexity of limb-girdle muscular dystrophy type 2E. Mol. Cell 5 141-51 PubMed GONUTS page
↑ ^7.0 ^7.1 Heydemann, A et al. (2007) Nuclear sequestration of delta-sarcoglycan disrupts the nuclear localization of lamin A/C and emerin in cardiomyocytes. Hum. Mol. Genet. 16 355-63 PubMed GONUTS page
↑ ^8.0 ^8.1 Chen, J et al. (2006) Identification of functional domains in sarcoglycans essential for their interaction and plasma membrane targeting. Exp. Cell Res. 312 1610-25 PubMed GONUTS page
↑ ^9.0 ^9.1 Wheeler, MT et al. (2002) Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy. Hum. Mol. Genet. 11 2147-54 PubMed GONUTS page
↑ Noguchi, S et al. (1999) Developmental expression of sarcoglycan gene products in cultured myocytes. Biochem. Biophys. Res. Commun. 262 88-93 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10481911-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Coral-Vazquez, R et al. (1999) Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy. Cell 98 465-74 PubMed GONUTS page

[PMID:23695275-3] 3.0 ^3.1 ^3.2 Rutschow, D et al. (2014) S151A δ-sarcoglycan mutation causes a mild phenotype of cardiomyopathy in mice. Eur. J. Hum. Genet. 22 119-25 PubMed GONUTS page

[PMID:19931597-4] 4.0 ^4.1 ^4.2 Solares-Pérez, A et al. (2010) Intracellular Ca2+ transients in delta-sarcoglycan knockout mouse skeletal muscle. Biochim. Biophys. Acta 1800 373-9 PubMed GONUTS page

[PMID:16403451-5] 5.0 ^5.1 Estrada, FJ et al. (2006) A novel isoform of delta-sarcoglycan is localized at the sarcoplasmic reticulum of mouse skeletal muscle. Biochem. Biophys. Res. Commun. 340 865-71 PubMed GONUTS page

[PMID:10678176-6] 6.0 ^6.1 Durbeej, M et al. (2000) Disruption of the beta-sarcoglycan gene reveals pathogenetic complexity of limb-girdle muscular dystrophy type 2E. Mol. Cell 5 141-51 PubMed GONUTS page

[PMID:17164264-7] 7.0 ^7.1 Heydemann, A et al. (2007) Nuclear sequestration of delta-sarcoglycan disrupts the nuclear localization of lamin A/C and emerin in cardiomyocytes. Hum. Mol. Genet. 16 355-63 PubMed GONUTS page

[PMID:16524571-8] 8.0 ^8.1 Chen, J et al. (2006) Identification of functional domains in sarcoglycans essential for their interaction and plasma membrane targeting. Exp. Cell Res. 312 1610-25 PubMed GONUTS page

[PMID:12189167-9] 9.0 ^9.1 Wheeler, MT et al. (2002) Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy. Hum. Mol. Genet. 11 2147-54 PubMed GONUTS page

[PMID:10448073-10] Noguchi, S et al. (1999) Developmental expression of sarcoglycan gene products in cultured myocytes. Biochem. Biophys. Res. Commun. 262 88-93 PubMed GONUTS page

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MOUSE:SGCD

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