MOUSE:SECR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sct
Protein Name(s)	Secretin
External Links
UniProt	Q08535
EMBL	U07568 X73580
CCDS	CCDS40184.1
PIR	JC2202
RefSeq	NP_035458.1
UniGene	Mm.4723
ProteinModelPortal	Q08535
SMR	Q08535
PRIDE	Q08535
Ensembl	ENSMUST00000167790
GeneID	20287
KEGG	mmu:20287
UCSC	uc009kkl.1
CTD	6343
MGI	MGI:99466
eggNOG	NOG329190
HOVERGEN	HBG017786
InParanoid	Q08535
KO	K05263
PhylomeDB	Q08535
Reactome	REACT_231304 REACT_242871
NextBio	297991
PRO	PR:Q08535
Proteomes	UP000000589
Bgee	Q08535
CleanEx	MM_SCT
ExpressionAtlas	Q08535
Genevestigator	Q08535
GO	GO:0005576 GO:0021542 GO:0043524 GO:0097150 GO:0008542
InterPro	IPR000532 IPR015675
PANTHER	PTHR17378
Pfam	PF00123
SMART	SM00070
PROSITE	PS00260

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0021766	hippocampus development	PMID:18534766^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	PMID:18534766^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050996	positive regulation of lipid catabolic process	PMID:24273196^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032098	regulation of appetite	PMID:20927047^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050996	positive regulation of lipid catabolic process	PMID:30449620^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032098	regulation of appetite	PMID:30449620^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	PMID:30449620^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002024	diet induced thermogenesis	PMID:30449620^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11384	C		Seeded From UniProt	complete
enables	GO:0046659	digestive hormone activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11384	F		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11384	F		Seeded From UniProt	complete
involved_in	GO:0009992	cellular water homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11384	P		Seeded From UniProt	complete
involved_in	GO:1903640	negative regulation of gastrin-induced gastric acid secretion	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001048642 RGD:3643	P		Seeded From UniProt	complete
involved_in	GO:0090274	positive regulation of somatostatin secretion	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001048642 RGD:3643	P		Seeded From UniProt	complete
involved_in	GO:0090187	positive regulation of pancreatic juice secretion	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001048642 RGD:3643	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001048642 RGD:3643	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001048642 RGD:3643	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001048642 RGD:3643	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903640	negative regulation of gastrin-induced gastric acid secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097150	neuronal stem cell population maintenance	PMID:21159798^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3815315	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090274	positive regulation of somatostatin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090187	positive regulation of pancreatic juice secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3643	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3643	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043950	positive regulation of cAMP-mediated signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3643	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:21159798^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3815315	P	regulates_o_occurs_in:(CL:0000047)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021542	dentate gyrus development	PMID:21159798^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3815315	P	results_in_development_of:(EMAPA:19037)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	PMID:21159798^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3815315	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3643	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3643	F		Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0009992	C		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0046659	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000532	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000532	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yamagata, T et al. (2008) Impaired hippocampal synaptic function in secretin deficient mice. Neuroscience 154 1417-22 PubMed GONUTS page
↑ Sekar, R & Chow, BK (2014) Lipolytic actions of secretin in mouse adipocytes. J. Lipid Res. 55 190-200 PubMed GONUTS page
↑ Cheng, CY et al. (2011) Central and peripheral administration of secretin inhibits food intake in mice through the activation of the melanocortin system. Neuropsychopharmacology 36 459-71 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Li, Y et al. (2018) Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation. Cell 175 1561-1574.e12 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Jukkola, PI et al. (2011) Secretin deficiency causes impairment in survival of neural progenitor cells in mice. Hum. Mol. Genet. 20 1000-7 PubMed GONUTS page

[PMID:18534766-1] 1.0 ^1.1 Yamagata, T et al. (2008) Impaired hippocampal synaptic function in secretin deficient mice. Neuroscience 154 1417-22 PubMed GONUTS page

[PMID:24273196-2] Sekar, R & Chow, BK (2014) Lipolytic actions of secretin in mouse adipocytes. J. Lipid Res. 55 190-200 PubMed GONUTS page

[PMID:20927047-3] Cheng, CY et al. (2011) Central and peripheral administration of secretin inhibits food intake in mice through the activation of the melanocortin system. Neuropsychopharmacology 36 459-71 PubMed GONUTS page

[PMID:30449620-4] 4.0 ^4.1 ^4.2 ^4.3 Li, Y et al. (2018) Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation. Cell 175 1561-1574.e12 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21159798-6] 6.0 ^6.1 ^6.2 ^6.3 Jukkola, PI et al. (2011) Secretin deficiency causes impairment in survival of neural progenitor cells in mice. Hum. Mol. Genet. 20 1000-7 PubMed GONUTS page

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MOUSE:SECR

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