MOUSE:SCNNG

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Scnn1g
Protein Name(s)	Amiloride-sensitive sodium channel subunit gamma Epithelial Na(+) channel subunit gamma Gamma-ENaC Gamma-NaCH Nonvoltage-gated sodium channel 1 subunit gamma SCNEG
External Links
UniProt	Q9WU39
EMBL	AF112187 BC021338
CCDS	CCDS21803.1
RefSeq	NP_035456.1
UniGene	Mm.35247
ProteinModelPortal	Q9WU39
SMR	Q9WU39
BioGrid	203107
MINT	MINT-90115
PhosphoSite	Q9WU39
PRIDE	Q9WU39
Ensembl	ENSMUST00000000221
GeneID	20278
KEGG	mmu:20278
UCSC	uc009jnv.1
CTD	6340
MGI	MGI:104695
eggNOG	NOG294559
GeneTree	ENSGT00760000119120
HOGENOM	HOG000236286
HOVERGEN	HBG058435
InParanoid	Q9WU39
KO	K04827
OMA	NWMYCYY
OrthoDB	EOG7T1R9N
PhylomeDB	Q9WU39
TreeFam	TF330663
Reactome	REACT_196640
NextBio	297971
PMAP-CutDB	Q9WU39
PRO	PR:Q9WU39
Proteomes	UP000000589
Bgee	Q9WU39
CleanEx	MM_SCNN1G
Genevestigator	Q9WU39
GO	GO:0016324 GO:0009897 GO:0070062 GO:0016021 GO:0005887 GO:0016020 GO:0034706 GO:0015280 GO:0050699 GO:0050891 GO:0050896 GO:0050909 GO:0055078 GO:0006814
InterPro	IPR004724 IPR001873 IPR020903
PANTHER	PTHR11690
Pfam	PF00858
PRINTS	PR01078
TIGRFAMs	TIGR00859
PROSITE	PS01206

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0055078	sodium ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51170	P		Seeded From UniProt	complete
involved_in	GO:0050891	multicellular organismal water homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51170	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51170	C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51170	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055078	sodium ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51170	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050891	multicellular organismal water homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51170	P		Seeded From UniProt	complete
enables	GO:0050699	WW domain binding	PMID:10212229^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P46934 UniProtKB:P46935	F		Seeded From UniProt	complete
enables	GO:0050699	WW domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51170	F		Seeded From UniProt	complete
enables	GO:0050699	WW domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3641	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035725	sodium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51170	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035313	wound healing, spreading of epidermal cells	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3641	P		Seeded From UniProt	complete
part_of	GO:0034706	sodium channel complex	PMID:17715136^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101782 MGI:MGI:104696	C		Seeded From UniProt	complete
part_of	GO:0034706	sodium channel complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51170	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3641	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:10409305^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21413931^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17373)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:17715136^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0015280	ligand-gated sodium channel activity	PMID:17715136^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101782 MGI:MGI:104696	F		Seeded From UniProt	complete
enables	GO:0015280	ligand-gated sodium channel activity	PMID:10409305^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015280	ligand-gated sodium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3641	F		Seeded From UniProt	complete
contributes_to	GO:0015280	ligand-gated sodium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51170	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3641	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:17715136^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006814	sodium ion transport	PMID:17715136^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101782 MGI:MGI:104696	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006814	sodium ion transport	PMID:16941024^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101782 MGI:MGI:104696	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006814	sodium ion transport	PMID:10409305^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006814	sodium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3641	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51170	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51170	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51170	C		Seeded From UniProt	complete
contributes_to	GO:0005272	sodium channel activity	PMID:16941024^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51170	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A5X2V1 ensembl:ENSP00000300061	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A5X2V1 ensembl:ENSP00000300061	C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51170 ensembl:ENSP00000300061	C		Seeded From UniProt	complete
involved_in	GO:0055078	sodium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51170 ensembl:ENSP00000300061	P		Seeded From UniProt	complete
involved_in	GO:0050891	multicellular organismal water homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51170 ensembl:ENSP00000300061	P		Seeded From UniProt	complete
enables	GO:0050699	WW domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51170 ensembl:ENSP00000300061	F		Seeded From UniProt	complete
involved_in	GO:0035725	sodium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51170 ensembl:ENSP00000300061	P		Seeded From UniProt	complete
part_of	GO:0034706	sodium channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51170 ensembl:ENSP00000300061	C		Seeded From UniProt	complete
enables	GO:0015280	ligand-gated sodium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51170 ensembl:ENSP00000300061	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51170 ensembl:ENSP00000300061	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51170 ensembl:ENSP00000300061	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51170 ensembl:ENSP00000300061	C		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51170 ensembl:ENSP00000300061	F		Seeded From UniProt	complete
enables	GO:0005272	sodium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001873 InterPro:IPR020903	F		Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001873 InterPro:IPR004724 InterPro:IPR020903	P		Seeded From UniProt	complete
enables	GO:0015280	ligand-gated sodium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004724	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001873 InterPro:IPR020903	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004724	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0739	P		Seeded From UniProt	complete
enables	GO:0005272	sodium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0894	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
involved_in	GO:0050896	response to stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0716	P		Seeded From UniProt	complete
involved_in	GO:0050909	sensory perception of taste	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0919	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Harvey, KF et al. (1999) All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+. J. Biol. Chem. 274 12525-30 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Lee, IH et al. (2007) Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J. Biol. Chem. 282 29866-73 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Ahn, YJ et al. (1999) Cloning and functional expression of the mouse epithelial sodium channel. Am. J. Physiol. 277 F121-9 PubMed GONUTS page
↑ Pearce, LR et al. (2011) Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Biochem. J. 436 169-79 PubMed GONUTS page
↑ ^5.0 ^5.1 Wakida, N et al. (2006) Inhibition of prostasin-induced ENaC activities by PN-1 and regulation of PN-1 expression by TGF-beta1 and aldosterone. Kidney Int. 70 1432-8 PubMed GONUTS page

[PMID:10212229-1] Harvey, KF et al. (1999) All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+. J. Biol. Chem. 274 12525-30 PubMed GONUTS page

[PMID:17715136-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Lee, IH et al. (2007) Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J. Biol. Chem. 282 29866-73 PubMed GONUTS page

[PMID:10409305-3] 3.0 ^3.1 ^3.2 Ahn, YJ et al. (1999) Cloning and functional expression of the mouse epithelial sodium channel. Am. J. Physiol. 277 F121-9 PubMed GONUTS page

[PMID:21413931-4] Pearce, LR et al. (2011) Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Biochem. J. 436 169-79 PubMed GONUTS page

[PMID:16941024-5] 5.0 ^5.1 Wakida, N et al. (2006) Inhibition of prostasin-induced ENaC activities by PN-1 and regulation of PN-1 expression by TGF-beta1 and aldosterone. Kidney Int. 70 1432-8 PubMed GONUTS page

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MOUSE:SCNNG

Contents

Annotations

Notes

References

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