MOUSE:S27A4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Slc27a4 (synonyms: Acsvl4, Fatp4)
Protein Name(s)	Long-chain fatty acid transport protein 4 FATP-4 Fatty acid transport protein 4 Solute carrier family 27 member 4
External Links
UniProt	Q91VE0
EMBL	AJ251113 AJ276492 AK036919 AK155388 AK170377 CT010312 BC023114 AF072759
CCDS	CCDS15858.1
RefSeq	NP_036119.1
UniGene	Mm.330113
ProteinModelPortal	Q91VE0
BioGrid	205025
STRING	10090.ENSMUSP00000078971
SwissLipids	SLP:000001141
TCDB	4.C.1.1.1
iPTMnet	Q91VE0
PhosphoSitePlus	Q91VE0
MaxQB	Q91VE0
PaxDb	Q91VE0
PeptideAtlas	Q91VE0
PRIDE	Q91VE0
Ensembl	ENSMUST00000080065
GeneID	26569
KEGG	mmu:26569
UCSC	uc008jaf.1
CTD	10999
MGI	MGI:1347347
eggNOG	KOG1179 ENOG410XQ8T
GeneTree	ENSGT00550000074420
HOGENOM	HOG000044189
HOVERGEN	HBG005642
InParanoid	Q91VE0
KO	K08745
OMA	LTALWAY
OrthoDB	EOG091G0B76
PhylomeDB	Q91VE0
TreeFam	TF313430
BRENDA	6.2.1.3
Reactome	R-MMU-804914
PRO	PR:Q91VE0
Proteomes	UP000000589
Bgee	ENSMUSG00000059316
Genevisible	Q91VE0
GO	GO:0031526 GO:0005783 GO:0005789 GO:0016021 GO:0016020 GO:0005902 GO:0005886 GO:0004467 GO:0000166 GO:0031957 GO:0006631 GO:0044539 GO:0001676 GO:0015909 GO:0001579 GO:0007584 GO:0043588 GO:0042760 GO:0000038
CDD	cd05939
InterPro	IPR025110 IPR020845 IPR000873 IPR030304 IPR022272
PANTHER	PTHR43107:SF11
Pfam	PF00501 PF13193
PROSITE	PS00455

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0062003	negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	PMID:23407971^[1]	ECO:0000314			P		“As shown in Fig. 2C, synthesis of 11cROL in the cells decreased as FATP4 expression levels increased.” UNIPROT name: S27A4 Organism: Mouse	complete CACAO 13072
involved_in	GO:0044539	long-chain fatty acid import into cell	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002875544 UniProtKB:Q6P1M0	P		Seeded From UniProt	complete
involved_in	GO:0042760	very long-chain fatty acid catabolic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347347 PANTHER:PTN002875544	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002875544 RGD:1307383	P		Seeded From UniProt	complete
part_of	GO:0005902	microvillus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347347 PANTHER:PTN002875544	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347098 MGI:MGI:1347347 PANTHER:PTN000645414 RGD:620927 UniProtKB:Q6PCB7	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002875544 UniProtKB:Q6P1M0	C		Seeded From UniProt	complete
enables	GO:0005324	long-chain fatty acid transporter activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001945407 SGD:S000000245	F		Seeded From UniProt	complete
enables	GO:0004467	long-chain fatty acid-CoA ligase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347098 MGI:MGI:1347099 MGI:MGI:1347347 PANTHER:PTN001945407 RGD:71103 UniProtKB:O14975 UniProtKB:O53551 UniProtKB:Q6P1M0	F		Seeded From UniProt	complete
involved_in	GO:0001579	medium-chain fatty acid transport	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347347 PANTHER:PTN002875544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044539	long-chain fatty acid import into cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6P1M0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043588	skin development	PMID:17401141^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2445864	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043588	skin development	PMID:16354193^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177426,MGI:MGI:2667329	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043588	skin development	PMID:12821645^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2667328	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042760	very long-chain fatty acid catabolic process	PMID:17522045^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031957	very long-chain fatty acid-CoA ligase activity	PMID:15653672^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2667328	F	occurs_in:(EMAPA:16894)\|occurs_in:(EMAPA:32874)\|occurs_in:(EMAPA:17525)	Seeded From UniProt	complete
enables	GO:0031957	very long-chain fatty acid-CoA ligase activity	PMID:18258213^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031957	very long-chain fatty acid-CoA ligase activity	PMID:17522045^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031957	very long-chain fatty acid-CoA ligase activity	PMID:15653672^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0031526	brush border membrane	PMID:14512415^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16058)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015909	long-chain fatty acid transport	PMID:14512415^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2684501	P	occurs_in:(EMAPA:32874) occurs_in:(CL:0000584)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015909	long-chain fatty acid transport	PMID:10518211^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:32764) occurs_in:(CL:0000584)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006631	fatty acid metabolic process	PMID:18843142^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2445864	P	occurs_in:(EMAPA:35440)	Seeded From UniProt	complete
part_of	GO:0005902	microvillus	PMID:10518211^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32764)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15496455^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6P1M0	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:17062637^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:15496455^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004467	long-chain fatty acid-CoA ligase activity	PMID:17062637^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004467	long-chain fatty acid-CoA ligase activity	PMID:15653672^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004467	long-chain fatty acid-CoA ligase activity	PMID:11404000^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004467	long-chain fatty acid-CoA ligase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6P1M0	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001676	long-chain fatty acid metabolic process	PMID:15653672^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001676	long-chain fatty acid metabolic process	PMID:11404000^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001676	long-chain fatty acid metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6P1M0	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001579	medium-chain fatty acid transport	PMID:18258213^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000245 SGD:S000005844	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001579	medium-chain fatty acid transport	PMID:17062637^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000038	very long-chain fatty acid metabolic process	PMID:17401141^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2445864	P	occurs_in:(EMAPA:17528)\|occurs_in:(EMAPA:17525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000038	very long-chain fatty acid metabolic process	PMID:17522045^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000038	very long-chain fatty acid metabolic process	PMID:15653672^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7V3 ensembl:ENSRNOP00000019500	P		Seeded From UniProt	complete
involved_in	GO:0044539	long-chain fatty acid import into cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P1M0 ensembl:ENSP00000300456	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P1M0 ensembl:ENSP00000300456	C		Seeded From UniProt	complete
enables	GO:0004467	long-chain fatty acid-CoA ligase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P1M0 ensembl:ENSP00000300456	F		Seeded From UniProt	complete
involved_in	GO:0001676	long-chain fatty acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P1M0 ensembl:ENSP00000300456	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000873	F		Seeded From UniProt	complete
enables	GO:0004467	long-chain fatty acid-CoA ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030304	F		Seeded From UniProt	complete
involved_in	GO:0015908	fatty acid transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030304	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030304	C		Seeded From UniProt	complete
enables	GO:0031957	very long-chain fatty acid-CoA ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030304	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15464426^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004467	long-chain fatty acid-CoA ligase activity	PMID:15464426^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001676	long-chain fatty acid metabolic process	PMID:15464426^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0445	P		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0436	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Li, S et al. (2013) Fatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase. J. Neurosci. 33 3178-89 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Moulson, CL et al. (2007) Keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in Slc27a4/Fatp4 mutant mice. J. Biol. Chem. 282 15912-20 PubMed GONUTS page
↑ Herrmann, T et al. (2005) Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency. J. Invest. Dermatol. 125 1228-35 PubMed GONUTS page
↑ Herrmann, T et al. (2003) Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J. Cell Biol. 161 1105-15 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Jia, Z et al. (2007) Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts. J. Biol. Chem. 282 20573-83 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Hall, AM et al. (2005) Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice. J. Biol. Chem. 280 11948-54 PubMed GONUTS page
↑ ^8.0 ^8.1 DiRusso, CC et al. (2008) Functional domains of the fatty acid transport proteins: studies using protein chimeras. Biochim. Biophys. Acta 1781 135-43 PubMed GONUTS page
↑ ^9.0 ^9.1 Gimeno, RE et al. (2003) Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J. Biol. Chem. 278 49512-6 PubMed GONUTS page
↑ ^10.0 ^10.1 Stahl, A et al. (1999) Identification of the major intestinal fatty acid transport protein. Mol. Cell 4 299-308 PubMed GONUTS page
↑ Shim, J et al. (2009) Fatty acid transport protein 4 is dispensable for intestinal lipid absorption in mice. J. Lipid Res. 50 491-500 PubMed GONUTS page
↑ ^12.0 ^12.1 Pohl, J et al. (2005) FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol. Biol. Cell 16 24-31 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Milger, K et al. (2006) Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. J. Cell. Sci. 119 4678-88 PubMed GONUTS page
↑ ^14.0 ^14.1 Herrmann, T et al. (2001) Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase. Gene 270 31-40 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Jia, Z et al. () X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA synthetases. Mol. Genet. Metab. 83 117-27 PubMed GONUTS page

[PMID:23407971-1] Li, S et al. (2013) Fatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase. J. Neurosci. 33 3178-89 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17401141-3] 3.0 ^3.1 Moulson, CL et al. (2007) Keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in Slc27a4/Fatp4 mutant mice. J. Biol. Chem. 282 15912-20 PubMed GONUTS page

[PMID:16354193-4] Herrmann, T et al. (2005) Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency. J. Invest. Dermatol. 125 1228-35 PubMed GONUTS page

[PMID:12821645-5] Herrmann, T et al. (2003) Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J. Cell Biol. 161 1105-15 PubMed GONUTS page

[PMID:17522045-6] 6.0 ^6.1 ^6.2 Jia, Z et al. (2007) Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts. J. Biol. Chem. 282 20573-83 PubMed GONUTS page

[PMID:15653672-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Hall, AM et al. (2005) Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice. J. Biol. Chem. 280 11948-54 PubMed GONUTS page

[PMID:18258213-8] 8.0 ^8.1 DiRusso, CC et al. (2008) Functional domains of the fatty acid transport proteins: studies using protein chimeras. Biochim. Biophys. Acta 1781 135-43 PubMed GONUTS page

[PMID:14512415-9] 9.0 ^9.1 Gimeno, RE et al. (2003) Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J. Biol. Chem. 278 49512-6 PubMed GONUTS page

[PMID:10518211-10] 10.0 ^10.1 Stahl, A et al. (1999) Identification of the major intestinal fatty acid transport protein. Mol. Cell 4 299-308 PubMed GONUTS page

[PMID:18843142-11] Shim, J et al. (2009) Fatty acid transport protein 4 is dispensable for intestinal lipid absorption in mice. J. Lipid Res. 50 491-500 PubMed GONUTS page

[PMID:15496455-12] 12.0 ^12.1 Pohl, J et al. (2005) FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol. Biol. Cell 16 24-31 PubMed GONUTS page

[PMID:17062637-13] 13.0 ^13.1 ^13.2 Milger, K et al. (2006) Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. J. Cell. Sci. 119 4678-88 PubMed GONUTS page

[PMID:11404000-14] 14.0 ^14.1 Herrmann, T et al. (2001) Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase. Gene 270 31-40 PubMed GONUTS page

[PMID:15464426-15] 15.0 ^15.1 ^15.2 Jia, Z et al. () X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA synthetases. Mol. Genet. Metab. 83 117-27 PubMed GONUTS page

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MOUSE:S27A4

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References

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