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MOUSE:RXFP1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Rxfp1 (synonyms: Gm1018, Lgr7)
Protein Name(s) Relaxin receptor 1

Leucine-rich repeat-containing G-protein coupled receptor 7 Relaxin family peptide receptor 1

External Links
UniProt Q6R6I7
EMBL AY509975
AY255542
CCDS CCDS17420.1
RefSeq NP_997617.1
UniGene Mm.331086
ProteinModelPortal Q6R6I7
SMR Q6R6I7
STRING 10090.ENSMUSP00000077611
GuidetoPHARMACOLOGY 351
PhosphoSite Q6R6I7
MaxQB Q6R6I7
PRIDE Q6R6I7
Ensembl ENSMUST00000078527
GeneID 381489
KEGG mmu:381489
UCSC uc008pnv.1
CTD 59350
MGI MGI:2682211
eggNOG COG4886
GeneTree ENSGT00760000119088
HOGENOM HOG000049056
HOVERGEN HBG026354
InParanoid Q6R6I7
KO K04306
OMA TRPFKEM
OrthoDB EOG77DJ5W
PhylomeDB Q6R6I7
TreeFam TF326185
Reactome REACT_198713
REACT_242871
ChiTaRS Rxfp1
NextBio 402138
PRO PR:Q6R6I7
Proteomes UP000000589
Bgee Q6R6I7
CleanEx MM_RXFP1
ExpressionAtlas Q6R6I7
Genevestigator Q6R6I7
GO GO:0016021
GO:0005886
GO:0004930
GO:0042562
GO:0046872
GO:0007188
GO:0030154
GO:0030198
GO:0060427
GO:0060658
GO:0007567
Gene3D 4.10.400.10
InterPro IPR000276
IPR017452
IPR023415
IPR002172
IPR001611
IPR003591
IPR000372
IPR008112
Pfam PF00001
PF00057
PF13855
PRINTS PR00237
PR01739
SMART SM00192
SM00369
SM00013
SUPFAM SSF57424
PROSITE PS50262
PS01209
PS50068
PS51450

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0009755

hormone-mediated signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0016650
PANTHER:PTN001224574
RGD:3007

P

Seeded From UniProt

complete

enables

GO:0008528

G protein-coupled peptide receptor activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001224574
RGD:3007

F

Seeded From UniProt

complete

involved_in

GO:0007190

activation of adenylate cyclase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96783
PANTHER:PTN001224574
RGD:3007

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2153463
MGI:MGI:96783
MGI:MGI:98849
PANTHER:PTN001224574
RGD:1302973
RGD:2632
UniProtKB:Q90674

P

Seeded From UniProt

complete

involved_in

GO:0007188

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2682211
PANTHER:PTN000687866

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003255
FB:FBgn0016650
MGI:MGI:96783
PANTHER:PTN001224574
RGD:3007
UniProtKB:O75473
UniProtKB:Q9BXB1

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000687866
RGD:1302973
UniProtKB:Q9HBX9

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060658

nipple morphogenesis

PMID:15256493[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3054831

P

has_participant:(EMAPA:36508)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060658

nipple morphogenesis

PMID:14701741[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3028654

P

has_participant:(EMAPA:36508)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060427

lung connective tissue development

PMID:15256493[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3054831

P

results_in_development_of:(EMAPA:35521)

Seeded From UniProt

complete

enables

GO:0042562

hormone binding

PMID:11809971[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030198

extracellular matrix organization

PMID:15256493[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3054831

P

occurs_in:(EMAPA:32697)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030154

cell differentiation

PMID:19073841[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

results_in_acquisition_of_features_of:(CL:0000186)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007567

parturition

PMID:15256493[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3054831

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007567

parturition

PMID:14701741[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3028654

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1302973

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007188

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

PMID:19073841[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P01347

P

occurs_in:(CL:0000186)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007188

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

PMID:11809971[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:11809971[4]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9HBX9

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1302973

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR008112

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008112

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008112

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR017452

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Kamat, AA et al. (2004) Genetic targeting of relaxin and insulin-like factor 3 receptors in mice. Endocrinology 145 4712-20 PubMed GONUTS page
  3. ↑ 3.0 3.1 Krajnc-Franken, MA et al. (2004) Impaired nipple development and parturition in LGR7 knockout mice. Mol. Cell. Biol. 24 687-96 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Hsu, SY et al. (2002) Activation of orphan receptors by the hormone relaxin. Science 295 671-4 PubMed GONUTS page
  5. ↑ 5.0 5.1 Mookerjee, I et al. (2009) Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2. FASEB J. 23 1219-29 PubMed GONUTS page
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