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MOUSE:RPTOR
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Rptor (synonyms: Raptor) | |
| Protein Name(s) | Regulatory-associated protein of mTOR
Raptor p150 target of rapamycin (TOR)-scaffold protein | |
| External Links | ||
| UniProt | Q8K4Q0 | |
| EMBL | AB082952 AK016530 AK029341 AK034306 AK040288 | |
| CCDS | CCDS25720.1 | |
| UniGene | Mm.209933 | |
| ProteinModelPortal | Q8K4Q0 | |
| DIP | DIP-46324N | |
| IntAct | Q8K4Q0 | |
| MINT | MINT-4607805 | |
| PhosphoSite | Q8K4Q0 | |
| MaxQB | Q8K4Q0 | |
| PaxDb | Q8K4Q0 | |
| PRIDE | Q8K4Q0 | |
| UCSC | uc007mqw.1 uc007mra.1 | |
| MGI | MGI:1921620 | |
| eggNOG | NOG269318 | |
| HOGENOM | HOG000184479 | |
| HOVERGEN | HBG059496 | |
| InParanoid | Q8K4Q0 | |
| PhylomeDB | Q8K4Q0 | |
| ChiTaRS | Rptor | |
| PRO | PR:Q8K4Q0 | |
| Proteomes | UP000000589 | |
| CleanEx | MM_4932417H02RIK | |
| Genevestigator | Q8K4Q0 | |
| GO | GO:0005737 GO:0005764 GO:0031931 GO:0016049 GO:0071230 GO:0032008 GO:0031929 | |
| Gene3D | 1.25.10.10 2.130.10.10 | |
| InterPro | IPR011989 IPR016024 IPR004083 IPR029347 IPR015943 IPR001680 IPR017986 | |
| PANTHER | PTHR12848 | |
| Pfam | PF14538 PF00400 | |
| SMART | SM00320 | |
| SUPFAM | SSF48371 SSF50978 | |
| PROSITE | PS50294 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0046676 |
negative regulation of insulin secretion |
ECO:0000315 |
P |
Fig.1D, insulinn secretion at 20mmol/l glucose was increased in the Raptor treated cells. |
complete | |||||
| GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
F |
Fig 3 shows the effect of mutations of the akt activity |
complete | |||||
| GO:0001932 |
regulation of protein phosphorylation |
ECO:0000315 |
P |
Figure 3 shows regulation of akt phosphorylation |
complete | |||||
| GO:0061179 |
negative regulation of insulin secretion involved in cellular response to glucose stimulus |
ECO:0000315 |
P |
Figure 1 shows Inhibition of raptor expression stimulates insulin secretion in INS-1 cells. |
complete | |||||
|
part_of |
GO:0010494 |
cytoplasmic stress granule |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001932 |
regulation of protein phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046676 |
negative regulation of insulin secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071230 |
cellular response to amino acid stimulus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032008 |
positive regulation of TOR signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031931 |
TORC1 complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031929 |
TOR signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001558 |
regulation of cell growth |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071902 |
positive regulation of protein serine/threonine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000304084 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071230 |
cellular response to amino acid stimulus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000304084 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031931 |
TORC1 complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0029840 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031929 |
TOR signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000304084 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0030674 |
protein binding, bridging |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000304084 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030307 |
positive regulation of cell growth |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000304084 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009267 |
cellular response to starvation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000304084 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008361 |
regulation of cell size |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000304084 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000304084 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1900087 |
positive regulation of G1/S transition of mitotic cell cycle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071902 |
positive regulation of protein serine/threonine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0071889 |
14-3-3 protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071233 |
cellular response to leucine |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071230 |
cellular response to amino acid stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045945 |
positive regulation of transcription by RNA polymerase III |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0043025 |
neuronal cell body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1311784 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042325 |
regulation of phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1311784 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0038202 |
TORC1 signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032008 |
positive regulation of TOR signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031931 |
TORC1 complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RefSeq:NP_065812 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031931 |
TORC1 complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031929 |
TOR signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031669 |
cellular response to nutrient levels |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030674 |
protein binding, bridging |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0030425 |
dendrite |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1311784 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0030307 |
positive regulation of cell growth |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030295 |
protein kinase activator activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030291 |
protein serine/threonine kinase inhibitor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1311784 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010800 |
positive regulation of peptidyl-threonine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0010494 |
cytoplasmic stress granule |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008361 |
regulation of cell size |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001938 |
positive regulation of endothelial cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1311784 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0001558 |
regulation of cell growth |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001156 |
TFIIIC-class transcription factor complex binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001032 |
RNA polymerase III type 3 promoter DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001031 |
RNA polymerase III type 2 promoter DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001030 |
RNA polymerase III type 1 promoter DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032147 |
activation of protein kinase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0030295 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071901 |
negative regulation of protein serine/threonine kinase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0030291 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031929 |
TOR signaling |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031931 |
TORC1 complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005764 |
lysosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Le Bacquer, O et al. (2013) mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells. J. Endocrinol. 216 21-9 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Jacinto, E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6 1122-8 PubMed GONUTS page
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p
- GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
- GO:0032008 ! positive regulation of TOR signaling
- GO:0071902 ! positive regulation of protein serine/threonine kinase activity
- GO:0030307 ! positive regulation of cell growth
- GO:1900087 ! positive regulation of G1/S transition of mitotic cell cycle
- GO:0045945 ! positive regulation of transcription by RNA polymerase III
- GO:0001938 ! positive regulation of endothelial cell proliferation
- GO:0010800 ! positive regulation of peptidyl-threonine phosphorylation
- GO:0044877 ! protein-containing complex binding
- GO:0030674 ! protein-macromolecule adaptor activity
- GO:0019901 ! protein kinase binding
- GO:0030295 ! protein kinase activator activity
- GO:0004674 ! protein serine/threonine kinase activity
- GO:0030291 ! protein serine/threonine kinase inhibitor activity
r
- GO:0008361 ! regulation of cell size
- GO:0001558 ! regulation of cell growth
- GO:0042325 ! regulation of phosphorylation
- GO:0001932 ! regulation of protein phosphorylation
- GO:0001031 ! RNA polymerase III type 2 promoter DNA binding
- GO:0001030 ! RNA polymerase III type 1 promoter DNA binding
- GO:0001032 ! RNA polymerase III type 3 promoter DNA binding
- Rodentia
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