MOUSE:RICTR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rictor (ECO:0000250 with UniProtKB:Q6R327) (synonyms: Kiaa1999 (ECO:0000312 with EMBL:BAD32604.1))
Protein Name(s)	Rapamycin-insensitive companion of mTOR AVO3 homolog mAVO3 Protein pianissimo
External Links
UniProt	Q6QI06
EMBL	AY497009 AY540053 AC102825 AC158901 BC058643 BC120903 AK036149 AK075662 AK173326
CCDS	CCDS37032.1
RefSeq	NP_084444.3
UniGene	Mm.275811
BioGrid	219616
DIP	DIP-46323N
IntAct	Q6QI06
PhosphoSite	Q6QI06
MaxQB	Q6QI06
PaxDb	Q6QI06
PRIDE	Q6QI06
Ensembl	ENSMUST00000061656
GeneID	78757
KEGG	mmu:78757
UCSC	uc007vdr.2
CTD	253260
MGI	MGI:1926007
eggNOG	NOG305760
GeneTree	ENSGT00390000002096
HOVERGEN	HBG060827
InParanoid	Q6QI06
KO	K08267
OMA	IGTILKW
OrthoDB	EOG7SBNMS
TreeFam	TF343656
Reactome	REACT_196588 REACT_226151 REACT_226341 REACT_261840
NextBio	349448
PRO	PR:Q6QI06
Proteomes	UP000000589
Bgee	Q6QI06
CleanEx	MM_4921505C17RIK
Genevestigator	Q6QI06
GO	GO:0031932 GO:0043022 GO:0031532 GO:0009790 GO:0030838 GO:0001938 GO:0050731 GO:0051897 GO:0032008 GO:0051896 GO:0032314 GO:0031929
InterPro	IPR016024 IPR028268 IPR028267 IPR029453 IPR029451 IPR029259 IPR029452
PANTHER	PTHR13298
Pfam	PF14663 PF14666 PF14664 PF14665 PF14668
SUPFAM	SSF48371

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0004674	protein serine/threonine kinase activity	PMID:23092880^[1]	ECO:0000314			F	figure 3 shows the effect of mutations of the akt activity	complete CACAO 5919
	GO:0001932	regulation of protein phosphorylation	PMID:23092880^[1]	ECO:0000315			P	Figure 3A shows regulation of akt phosphorylation.	complete CACAO 6199
involved_in	GO:0001932	regulation of protein phosphorylation	PMID:23092880^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051896	regulation of protein kinase B signaling	PMID:16962829^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043022	ribosome binding	PMID:21045808^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0031932	TORC2 complex	PMID:16962653^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6R327	P	Seeded From UniProt	complete
involved_in	GO:0009792	embryo development ending in birth or egg hatching	PMID:16962829^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000329282 RGD:1307224 dictyBase:DDB_G0277399	P	Seeded From UniProt	complete
involved_in	GO:0042325	regulation of phosphorylation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000329282 RGD:1307224	P	Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000329282 UniProtKB:Q6R327	P	Seeded From UniProt	complete
part_of	GO:0031932	TORC2 complex	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0031006 MGI:MGI:1926007 PANTHER:PTN000329282 PomBase:SPBC12C2.02c UniProtKB:Q6R327 WB:WBGene00009245 dictyBase:DDB_G0277399	C	Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000329282 UniProtKB:Q6R327	P	Seeded From UniProt	complete
involved_in	GO:0030950	establishment or maintenance of actin cytoskeleton polarity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000329282 SGD:S000000895	P	Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000329282 dictyBase:DDB_G0277399	P	Seeded From UniProt	complete
enables	GO:0008047	enzyme activator activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000329282 dictyBase:DDB_G0277399	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000114	regulation of establishment of cell polarity	PMID:24740015^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3703321	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307224	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051896	regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6R327	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:15467718^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050727	regulation of inflammatory response	PMID:24740015^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3703321	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043087	regulation of GTPase activity	PMID:15467718^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042325	regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307224	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033135	regulation of peptidyl-serine phosphorylation	PMID:24740015^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032956	regulation of actin cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6R327	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032008	positive regulation of TOR signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6R327	P	Seeded From UniProt	complete
part_of	GO:0031932	TORC2 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6R327	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6R327	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030838	positive regulation of actin filament polymerization	PMID:15467718^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6R327	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6R327	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:24740015^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3703321	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307224	P	Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008047	P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M4J0 ensembl:ENSRNOP00000030782	P	Seeded From UniProt	complete
involved_in	GO:0042325	regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M4J0 ensembl:ENSRNOP00000030782	P	Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M4J0 ensembl:ENSRNOP00000030782	P	Seeded From UniProt	complete
involved_in	GO:0051896	regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R327 ensembl:ENSP00000296782	P	Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R327 ensembl:ENSP00000296782	P	Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R327 ensembl:ENSP00000296782	P	Seeded From UniProt	complete
part_of	GO:0031932	TORC2 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R327 ensembl:ENSP00000296782	C	Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R327 ensembl:ENSP00000296782	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R327 ensembl:ENSP00000296782	F	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6R327 ensembl:ENSP00000296782	P	Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028268	P	Seeded From UniProt	complete
part_of	GO:0031932	TORC2 complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028268	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Le Bacquer, O et al. (2013) mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells. J. Endocrinol. 216 21-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Shiota, C et al. (2006) Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev. Cell 11 583-9 PubMed GONUTS page
↑ Oh, WJ et al. (2010) mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 29 3939-51 PubMed GONUTS page
↑ Jacinto, E et al. (2006) SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127 125-37 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Festuccia, WT et al. (2014) Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide. PLoS ONE 9 e95432 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Jacinto, E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6 1122-8 PubMed GONUTS page

[PMID:23092880-1] 1.0 ^1.1 ^1.2 Le Bacquer, O et al. (2013) mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells. J. Endocrinol. 216 21-9 PubMed GONUTS page

[PMID:16962829-2] 2.0 ^2.1 Shiota, C et al. (2006) Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev. Cell 11 583-9 PubMed GONUTS page

[PMID:21045808-3] Oh, WJ et al. (2010) mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 29 3939-51 PubMed GONUTS page

[PMID:16962653-4] Jacinto, E et al. (2006) SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127 125-37 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24740015-6] 6.0 ^6.1 ^6.2 ^6.3 Festuccia, WT et al. (2014) Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide. PLoS ONE 9 e95432 PubMed GONUTS page

[PMID:15467718-7] 7.0 ^7.1 ^7.2 Jacinto, E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6 1122-8 PubMed GONUTS page

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MOUSE:RICTR

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