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MOUSE:RASK

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Kras (synonyms: Kras2)
Protein Name(s) GTPase KRas

K-Ras 2 Ki-Ras c-K-ras c-Ki-ras GTPase KRas, N-terminally processed

External Links
UniProt P32883
EMBL X02452
X02453
X02454
X02456
X02455
BC004642
BC010202
K01927
X00485
CCDS CCDS20693.1
PIR A01365
B01365
RefSeq NP_067259.4
XP_006506981.1
XP_006536102.1
UniGene Mm.383182
ProteinModelPortal P32883
SMR P32883
BioGrid 201012
DIP DIP-29362N
IntAct P32883
MINT MINT-216577
PhosphoSite P32883
MaxQB P32883
PaxDb P32883
PRIDE P32883
Ensembl ENSMUST00000032399
ENSMUST00000111710
GeneID 16653
KEGG mmu:16653
UCSC uc009eri.2
CTD 3845
MGI MGI:96680
eggNOG COG1100
HOGENOM HOG000233973
HOVERGEN HBG009351
InParanoid P32883
KO K07827
OMA KKSRTRC
OrthoDB EOG7QVM41
PhylomeDB P32883
TreeFam TF312796
Reactome REACT_188185
REACT_188528
REACT_188530
REACT_188574
REACT_188578
REACT_188580
REACT_196455
REACT_198350
REACT_199122
REACT_199123
REACT_207601
REACT_211860
REACT_230639
REACT_234357
REACT_237640
REACT_237796
REACT_239466
REACT_239722
REACT_241824
REACT_245086
REACT_245103
REACT_247566
REACT_257146
REACT_260286
REACT_94437
ChiTaRS Kras
NextBio 290345
PRO PR:P32883
Proteomes UP000000589
Bgee P32883
ExpressionAtlas P32883
Genevestigator P32883
GO GO:0005737
GO:0031234
GO:0016020
GO:0045121
GO:0005739
GO:0005886
GO:0019003
GO:0019002
GO:0005525
GO:0003924
GO:0032403
GO:0030036
GO:0019221
GO:0060441
GO:0045596
GO:0043524
GO:0008284
GO:0010628
GO:0043406
GO:0051092
GO:0051000
GO:0035022
GO:0007265
GO:0048169
GO:0032228
GO:0051384
GO:0051385
GO:0035176
GO:0051146
GO:0008542
Gene3D 3.40.50.300
InterPro IPR027417
IPR005225
IPR001806
IPR020849
PANTHER PTHR24070
Pfam PF00071
PRINTS PR00449
SMART SM00173
SUPFAM SSF52540
TIGRFAMs TIGR00231
PROSITE PS51421

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0038002

endocrine signaling

PMID:25133424[1]

ECO:0000315

P

Figure 1A shows the relationship between K-RAS-GTP binding and intracellular signaling. Figure 3 shows K-RAS signaling suppresses endocrine cell growth.

complete
CACAO 10480

involved_in

GO:0031647

regulation of protein stability

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01116

P

Seeded From UniProt

complete

involved_in

GO:0038002

endocrine signaling

PMID:25133424[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031234

extrinsic component of cytoplasmic side of plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01116

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01116

C

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P01116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000774

positive regulation of cellular senescence

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2981

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060441

epithelial tube branching involved in lung morphogenesis

PMID:24058167[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98371

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060441

epithelial tube branching involved in lung morphogenesis

PMID:24058167[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051146

striated muscle cell differentiation

PMID:15542848[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97874

P

  • occurs_in:(EMAPA:18167)
  • results_in_acquisition_of_features_of:(CL:0000188)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2981

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051000

positive regulation of nitric-oxide synthase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2981

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048873

homeostasis of number of cells within a tissue

PMID:24675817[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99511

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048169

regulation of long-term neuronal synaptic plasticity

PMID:11793011[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

  • regulates_o_occurs_in:(EMAPA:32768)
  • regulates_o_has_participant:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045596

negative regulation of cell differentiation

PMID:24058167[2]

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_o_results_in_acquisition_of_features_of:(CL:0002062)
  • occurs_in:(CL:0000082)

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2981

C

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

PMID:23209302[6]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01116

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:10845775[7]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96224
MGI:MGI:97306

P

  • occurs_in:(EMAPA:16668)
  • regulates_o_occurs_in:(CL:0000029)|occurs_in(EMAPA:16797)
  • regulates_o_occurs_in:(CL:0000029)|occurs_in(EMAPA:16798)
  • regulates_o_occurs_in:(CL:0000029)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043406

positive regulation of MAP kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2981

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01116

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035022

positive regulation of Rac protein signal transduction

PMID:15665300[8]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

  • regulates_o_occurs_in:(EMAPA:32842)
  • regulates_o_occurs_in:(CL:0000127)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032228

regulation of synaptic transmission, GABAergic

PMID:11793011[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

  • regulates_o_occurs_in:(EMAPA:32768)
  • regulates_o_has_participant:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031647

regulation of protein stability

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01116

P

Seeded From UniProt

complete

part_of

GO:0031234

extrinsic component of cytoplasmic side of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01116

C

Seeded From UniProt

complete

enables

GO:0030275

LRR domain binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2981

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030036

actin cytoskeleton organization

PMID:15665300[8]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

  • occurs_in:(EMAPA:32842)
  • occurs_in:(CL:0000127)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021897

forebrain astrocyte development

PMID:22577135[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2429948

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019221

cytokine-mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2981

P

Seeded From UniProt

complete

enables

GO:0019003

GDP binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2981

F

Seeded From UniProt

complete

enables

GO:0019002

GMP binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2981

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:14966563[10]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1888594

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:10085069[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

PMID:22577135[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2429948

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008542

visual learning

PMID:11793011[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

PMID:15665300[8]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01116

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007265

Ras protein signal transduction

PMID:15665300[8]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

P

  • occurs_in:(EMAPA:32842)
  • occurs_in:(CL:0000127)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007265

Ras protein signal transduction

PMID:22577135[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2429948

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2981

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01116

C

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:15665300[8]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97306

F

  • occurs_in:(EMAPA:32842)
  • occurs_in:(CL:0000127)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01116

P

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01116
ensembl:ENSP00000256078

F

Seeded From UniProt

complete

involved_in

GO:0031647

regulation of protein stability

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01116
ensembl:ENSP00000256078

P

Seeded From UniProt

complete

part_of

GO:0031234

extrinsic component of cytoplasmic side of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01116
ensembl:ENSP00000256078

C

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01116
ensembl:ENSP00000256078

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01116
ensembl:ENSP00000256078

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01116
ensembl:ENSP00000256078

C

Seeded From UniProt

complete

involved_in

GO:0001934

positive regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P01116
ensembl:ENSP00000256078

P

Seeded From UniProt

complete

involved_in

GO:2000774

positive regulation of cellular senescence

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

P

Seeded From UniProt

complete

involved_in

GO:0051385

response to mineralocorticoid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

P

Seeded From UniProt

complete

involved_in

GO:0051384

response to glucocorticoid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

P

Seeded From UniProt

complete

involved_in

GO:0051000

positive regulation of nitric-oxide synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

P

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

C

Seeded From UniProt

complete

involved_in

GO:0043406

positive regulation of MAP kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

P

Seeded From UniProt

complete

involved_in

GO:0035900

response to isolation stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

P

Seeded From UniProt

complete

enables

GO:0030275

LRR domain binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

F

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

P

Seeded From UniProt

complete

enables

GO:0019003

GDP binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

F

Seeded From UniProt

complete

enables

GO:0019002

GMP binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

F

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

C

Seeded From UniProt

complete

involved_in

GO:0001889

liver development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P08644
ensembl:ENSRNOP00000012588

P

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001806

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001806
InterPro:IPR005225
InterPro:IPR020849

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020849

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020849

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-NUL-1250472
Reactome:R-NUL-1250468
Reactome:R-MMU-9029152

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007265

Ras protein signal transduction

PMID:10498879[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:10498879[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Chamberlain, CE et al. (2014) Menin determines K-RAS proliferative outputs in endocrine cells. J. Clin. Invest. 124 4093-101 PubMed GONUTS page
  2. 2.0 2.1 2.2 Chang, DR et al. (2013) Lung epithelial branching program antagonizes alveolar differentiation. Proc. Natl. Acad. Sci. U.S.A. 110 18042-51 PubMed GONUTS page
  3. Takahashi, C et al. (2004) Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression. Mol. Cell. Biol. 24 10406-15 PubMed GONUTS page
  4. Yamashita, H et al. (2014) Role of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium. PLoS ONE 9 e92904 PubMed GONUTS page
  5. 5.0 5.1 5.2 Costa, RM et al. (2002) Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature 415 526-30 PubMed GONUTS page
  6. Ahmed, SM et al. (2012) KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J. Cell Biol. 199 951-67 PubMed GONUTS page
  7. Vogel, KS et al. (2000) Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons. Mol. Cell. Neurosci. 15 398-407 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 Dasgupta, B et al. (2005) Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes. Cancer Res. 65 236-45 PubMed GONUTS page
  9. 9.0 9.1 9.2 Ryu, MJ et al. (2012) Oncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosis. J. Biol. Chem. 287 22948-58 PubMed GONUTS page
  10. Bergo, MO et al. (2004) Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J. Clin. Invest. 113 539-50 PubMed GONUTS page
  11. Kim, E et al. (1999) Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. J. Biol. Chem. 274 8383-90 PubMed GONUTS page
  12. 12.0 12.1 Adams, JM et al. (1999) Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector. Oncogene 18 5268-77 PubMed GONUTS page