MOUSE:RALA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rala (synonyms: Ral, Ral-a)
Protein Name(s)	Ras-related protein Ral-A
External Links
UniProt	P63321
EMBL	Z48587 AF244951 BC031741
CCDS	CCDS26255.1
RefSeq	NP_062364.3
UniGene	Mm.27348
ProteinModelPortal	P63321
SMR	P63321
BioGrid	207790
IntAct	P63321
MINT	MINT-1866102
PhosphoSite	P63321
MaxQB	P63321
PaxDb	P63321
PRIDE	P63321
Ensembl	ENSMUST00000009003
GeneID	56044
KEGG	mmu:56044
UCSC	uc007pof.1
CTD	5898
MGI	MGI:1927243
eggNOG	COG1100
GeneTree	ENSGT00770000120468
HOGENOM	HOG000233973
HOVERGEN	HBG009351
InParanoid	P63321
KO	K07834
OMA	DSCCVIL
OrthoDB	EOG7QVM41
PhylomeDB	P63321
TreeFam	TF312796
Reactome	REACT_199054 REACT_207601
NextBio	311812
PRO	PR:P63321
Proteomes	UP000000589
Bgee	P63321
Genevestigator	P63321
GO	GO:0032154 GO:0030659 GO:0030139 GO:0070062 GO:0030496 GO:0005886 GO:0031755 GO:0005525 GO:0003924 GO:0031532 GO:0000910 GO:0006887 GO:0051665 GO:0051491 GO:0007265 GO:0017157
Gene3D	3.40.50.300
InterPro	IPR027417 IPR028412 IPR005225 IPR001806 IPR020849
PANTHER	PTHR24070 PTHR24070:SF174
Pfam	PF00071
PRINTS	PR00449
SMART	SM00173
SUPFAM	SSF52540
TIGRFAMs	TIGR00231
PROSITE	PS51421

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001843	neural tube closure	PMID:23063435^[1]	ECO:0000315			P		Figure 1 depicts exencephaly in null Rala embryos.	complete CACAO 5341
involved_in	GO:0001843	neural tube closure	PMID:23063435^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	PMID:17634366^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
involved_in	GO:0051665	membrane raft localization	PMID:20005108^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11233	C		Seeded From UniProt	complete
enables	GO:0031755	Edg-2 lysophosphatidic acid receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11233	F		Seeded From UniProt	complete
involved_in	GO:0017157	regulation of exocytosis	PMID:20005108^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11233	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:21148297^[4]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:17765682^[5]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051665	membrane raft localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11233	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051491	positive regulation of filopodium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11233	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11233	F		Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11233	C		Seeded From UniProt	complete
enables	GO:0031755	Edg-2 lysophosphatidic acid receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11233	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11233	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11233	P		Seeded From UniProt	complete
colocalizes_with	GO:0030139	endocytic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11233	C		Seeded From UniProt	complete
enables	GO:0019003	GDP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11233	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017157	regulation of exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11233	P		Seeded From UniProt	complete
enables	GO:0017022	myosin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11233	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11233	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11233	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11233	F		Seeded From UniProt	complete
involved_in	GO:0051665	membrane raft localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11233 ensembl:ENSP00000005257	P		Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11233 ensembl:ENSP00000005257	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11233 ensembl:ENSP00000005257	F		Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11233 ensembl:ENSP00000005257	C		Seeded From UniProt	complete
enables	GO:0031755	Edg-2 lysophosphatidic acid receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11233 ensembl:ENSP00000005257	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11233 ensembl:ENSP00000005257	F		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11233 ensembl:ENSP00000005257	P		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11233 ensembl:ENSP00000005257	C		Seeded From UniProt	complete
enables	GO:0019003	GDP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11233 ensembl:ENSP00000005257	F		Seeded From UniProt	complete
involved_in	GO:0017157	regulation of exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11233 ensembl:ENSP00000005257	P		Seeded From UniProt	complete
enables	GO:0017022	myosin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11233 ensembl:ENSP00000005257	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11233 ensembl:ENSP00000005257	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11233 ensembl:ENSP00000005257	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11233 ensembl:ENSP00000005257	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR028412	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR005225 InterPro:IPR020849	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028412	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020849	P		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028412	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020849	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	Reactome:R-MMU-2316351 Reactome:R-MMU-2316348 Reactome:R-MMU-2255339 Reactome:R-MMU-1458501	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006887	exocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0268	P		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0090543	Flemming body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0490	C		Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0467	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Peschard, P et al. (2012) Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis. Curr. Biol. 22 2063-8 PubMed GONUTS page
↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ ^3.0 ^3.1 Balasubramanian, N et al. (2010) RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Curr. Biol. 20 75-9 PubMed GONUTS page
↑ Chen, XW et al. (2011) A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Mol. Biol. Cell 22 141-52 PubMed GONUTS page
↑ Chen, XW et al. (2007) Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Dev. Cell 13 391-404 PubMed GONUTS page

[PMID:23063435-1] 1.0 ^1.1 Peschard, P et al. (2012) Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis. Curr. Biol. 22 2063-8 PubMed GONUTS page

[PMID:17634366-2] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:20005108-3] 3.0 ^3.1 Balasubramanian, N et al. (2010) RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Curr. Biol. 20 75-9 PubMed GONUTS page

[PMID:21148297-4] Chen, XW et al. (2011) A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Mol. Biol. Cell 22 141-52 PubMed GONUTS page

[PMID:17765682-5] Chen, XW et al. (2007) Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Dev. Cell 13 391-404 PubMed GONUTS page

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MOUSE:RALA

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