GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

MOUSE:Q99M68

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Oprm1 (ECO:0000313 with MGI:MGI:97441)
Protein Name(s) Mu-opioid receptor (ECO:0000313 with EMBL:AAK31600.1)
External Links
UniProt Q99M68
EMBL AY028944
UniGene Mm.439715
ProteinModelPortal Q99M68
BindingDB Q99M68
MGI MGI:97441
Bgee Q99M68
ExpressionAtlas Q99M68
Genevestigator Q99M68
GO GO:0032839
GO:0032590
GO:0005925
GO:0016021
GO:0016020
GO:0045121
GO:0043204
GO:0042383
GO:0004979
GO:0038047
GO:0004985
GO:0005245
GO:0002438
GO:0007191
GO:0007193
GO:0031635
GO:0048149
GO:0033554
GO:0007626
GO:0007194
GO:0043951
GO:0051481
GO:0045019
GO:0061358
GO:0007200
GO:0032100
GO:0043950
GO:0007204
GO:0070374
GO:0045429
GO:0060079
GO:2000310
GO:0051930
GO:0042220
GO:0032094
GO:0070848
GO:0032496
GO:0042060
InterPro IPR000276
IPR017452
IPR001418
Pfam PF00001
PRINTS PR00237
PR00384
PROSITE PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0035176

social behavior

PMID:22231481[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9Z2D6

P

Seeded From UniProt

complete

involved_in

GO:0038003

opioid receptor signaling pathway

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004985

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

enables

GO:0004985

opioid receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001418

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR001418

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR001418
InterPro:IPR017452

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0035176

social behavior

PMID:22231481[1]

ECO:0000316

UniProtKB:Q9Z2D6


P

Figure 6a shows that the mice who have already received social deficits through mutation are able to regain social behavior function through reducing the Oprm1 gene. This graph shows wild type mice having the highest amount of socialization time and the mutated mice with the most reduction of the Oprm1 gene regaining a lot of their lost socialization skills.

complete
CACAO 10047

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Samaco, RC et al. (2012) Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome. Nat. Genet. 44 206-11 PubMed GONUTS page