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MOUSE:Q68V28

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Scn1a (ECO:0000313 with EMBL:CAH17959.1, ECO:0000313 with MGI:MGI:98246)
Protein Name(s) Voltage-gated sodium channel alpha subunit Nav1.1 (ECO:0000313 with EMBL:CAH17959.1)
External Links
UniProt Q68V28
EMBL AJ810515
UniGene Mm.439704
Mm.455166
ProteinModelPortal Q68V28
BindingDB Q68V28
MGI MGI:98246
ChiTaRS Scn1a
Bgee Q68V28
ExpressionAtlas Q68V28
Genevestigator Q68V28
GO GO:0030424
GO:0043194
GO:0014704
GO:0016020
GO:0043025
GO:0033268
GO:0034706
GO:0030315
GO:0005267
GO:0005248
GO:0001508
GO:0007628
GO:0086010
GO:0050884
GO:0019228
GO:0019227
GO:0042391
GO:0035725
GO:0006814
Gene3D 1.20.120.350
InterPro IPR027359
IPR005821
IPR003091
Pfam PF00520
PRINTS PR00169

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006814

sodium ion transport

PMID:27281198[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005248

voltage-gated sodium channel activity

PMID:27281198[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0050966

detection of mechanical stimulus involved in sensory perception of pain

PMID:27281198[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030018

Z disc

PMID:17884088[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0086010

membrane depolarization during action potential

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000004140
UniProtKB:Q14524

P

Seeded From UniProt

complete

involved_in

GO:0035725

sodium ion transmembrane transport

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0264255
PANTHER:PTN000798901
RGD:3632
RGD:3637
UniProtKB:Q14524
UniProtKB:Q15858
UniProtKB:Q9Y5Y9

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108029
MGI:MGI:1345149
MGI:MGI:98246
MGI:MGI:98248
PANTHER:PTN000798922
RGD:3635

C

Seeded From UniProt

complete

involved_in

GO:0019228

neuronal action potential

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98246
PANTHER:PTN000798901
RGD:3632
RGD:3635
RGD:3638
RGD:69364
RGD:69368

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102965
MGI:MGI:108029
MGI:MGI:1201678
MGI:MGI:1345149
MGI:MGI:98251
PANTHER:PTN000004140
RGD:3638
RGD:68942
RGD:69364
UniProtKB:O43497
UniProtKB:P35498
UniProtKB:Q14524

C

Seeded From UniProt

complete

enables

GO:0005248

voltage-gated sodium channel activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0264255
MGI:MGI:108029
MGI:MGI:1345149
MGI:MGI:98246
MGI:MGI:98248
MGI:MGI:98250
MGI:MGI:98251
PANTHER:PTN000004137
RGD:3629
RGD:3632
RGD:3635
RGD:3638
RGD:69364
RGD:69368
UniProtKB:Q14524
UniProtKB:Q15858
UniProtKB:Q99250
UniProtKB:Q9UQD0
UniProtKB:Q9Y5Y9

F

Seeded From UniProt

complete

part_of

GO:0001518

voltage-gated sodium channel complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000004137
RGD:3632
RGD:3635
RGD:3638
RGD:69364
RGD:69368
UniProtKB:Q14524
UniProtKB:Q9Y5Y9

C

Seeded From UniProt

complete

part_of

GO:0099056

integral component of presynaptic membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69364

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0086002

cardiac muscle cell action potential involved in contraction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P35498

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050884

neuromuscular process controlling posture

PMID:17928448[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3665322

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050884

neuromuscular process controlling posture

PMID:16921370[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3665322

P

Seeded From UniProt

complete

part_of

GO:0043194

axon initial segment

PMID:17537961[6]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32842)
  • part_of:(CL:0000099)

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

PMID:17928448[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:35223)
  • part_of:(CL:0000121)

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

PMID:17537961[6]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32845)
  • part_of:(CL:0000099)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042391

regulation of membrane potential

PMID:17928448[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3665322

P

Seeded From UniProt

complete

part_of

GO:0034706

sodium channel complex

PMID:15272007[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P97952
UniProtKB:Q9JJV9
UniProtKB:Q9WTU3

C

  • part_of:(EMAPA:32748)
  • part_of:(CL:0000746)

Seeded From UniProt

complete

part_of

GO:0033268

node of Ranvier

PMID:17537961[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:35235)|part_of:(EMAPA:35253)

Seeded From UniProt

complete

enables

GO:0031402

sodium ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69364

F

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:17928448[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:35223)
  • part_of:(CL:0000121)

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:17537961[6]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17787)
  • part_of:(CL:0000118)|part_of:(EMAPA:17787)
  • part_of:(CL:0000121)|part_of:(EMAPA:32845)
  • part_of:(CL:0000099)

Seeded From UniProt

complete

part_of

GO:0030315

T-tubule

PMID:15746173[8]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32748)
  • part_of:(CL:0000746)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019228

neuronal action potential

PMID:17928448[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3665322

P

  • occurs_in:(EMAPA:35223)
  • occurs_in:(CL:0000121)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019228

neuronal action potential

PMID:16921370[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3665322

P

  • occurs_in:(EMAPA:32845)
  • occurs_in:(CL:0000103)|occurs_in:(EMAPA:32845)
  • occurs_in:(CL:0000617)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019228

neuronal action potential

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69364

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019227

neuronal action potential propagation

PMID:17322896[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3713733

P

Seeded From UniProt

complete

part_of

GO:0016604

nuclear body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P35498

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:17537961[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:10827969[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0014704

intercalated disc

PMID:15746173[8]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32748)
  • part_of:(CL:0000746)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007628

adult walking behavior

PMID:17928448[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3665322

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007628

adult walking behavior

PMID:17537961[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3713733

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006814

sodium ion transport

PMID:17928448[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3665322

P

  • occurs_in:(EMAPA:35223)
  • occurs_in:(CL:0000121)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006814

sodium ion transport

PMID:16921370[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3665322

P

  • occurs_in:(EMAPA:32845)
  • occurs_in:(CL:0000103)|occurs_in:(EMAPA:32845)
  • occurs_in:(CL:0000617)

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P35498

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69364

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P35498

C

Seeded From UniProt

complete

enables

GO:0005248

voltage-gated sodium channel activity

PMID:16921370[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3665322

F

  • occurs_in:(EMAPA:32845)
  • occurs_in:(CL:0000103)|occurs_in:(EMAPA:32845)
  • occurs_in:(CL:0000617)

Seeded From UniProt

complete

enables

GO:0005248

voltage-gated sodium channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69364

F

Seeded From UniProt

complete

part_of

GO:0001518

voltage-gated sodium channel complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:69364

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001508

action potential

PMID:17928448[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3665322

P

  • occurs_in:(EMAPA:35223)
  • regulates_o_occurs_in:(CL:0000121)

Seeded From UniProt

complete

involved_in

GO:0086002

cardiac muscle cell action potential involved in contraction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35498
ensembl:ENSP00000303540

P

Seeded From UniProt

complete

part_of

GO:0016604

nuclear body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35498
ensembl:ENSP00000303540

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35498
ensembl:ENSP00000303540

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35498
ensembl:ENSP00000303540

C

Seeded From UniProt

complete

part_of

GO:0001518

voltage-gated sodium channel complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001696
InterPro:IPR008051
InterPro:IPR010526

C

Seeded From UniProt

complete

enables

GO:0005216

ion channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

F

Seeded From UniProt

complete

enables

GO:0005248

voltage-gated sodium channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001696
InterPro:IPR008051
InterPro:IPR010526

F

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

P

Seeded From UniProt

complete

involved_in

GO:0006814

sodium ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001696
InterPro:IPR008051
InterPro:IPR010526

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

C

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005821

P

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

involved_in

GO:0034765

regulation of ion transmembrane transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0851

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0006814

sodium ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0739

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0005272

sodium channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0894

F

Seeded From UniProt

complete

enables

GO:0005244

voltage-gated ion channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0851

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Osteen, JD et al. (2016) Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain. Nature 534 494-9 PubMed GONUTS page
  2. Lopez-Santiago, LF et al. (2007) Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J. Mol. Cell. Cardiol. 43 636-47 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Kalume, F et al. (2007) Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy. J. Neurosci. 27 11065-74 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Yu, FH et al. (2006) Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat. Neurosci. 9 1142-9 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Ogiwara, I et al. (2007) Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J. Neurosci. 27 5903-14 PubMed GONUTS page
  7. Malhotra, JD et al. (2004) Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes. J. Biol. Chem. 279 40748-54 PubMed GONUTS page
  8. 8.0 8.1 Haufe, V et al. (2005) Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart. J. Physiol. (Lond.) 564 683-96 PubMed GONUTS page
  9. Brunham, LR et al. (2007) Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat. Med. 13 340-7 PubMed GONUTS page
  10. Planells-Cases, R et al. (2000) Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice. Biophys. J. 78 2878-91 PubMed GONUTS page