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MOUSE:Q68V28
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Scn1a (ECO:0000313 with EMBL:CAH17959.1, ECO:0000313 with MGI:MGI:98246) | |
Protein Name(s) | Voltage-gated sodium channel alpha subunit Nav1.1 (ECO:0000313 with EMBL:CAH17959.1) | |
External Links | ||
UniProt | Q68V28 | |
EMBL | AJ810515 | |
UniGene | Mm.439704 Mm.455166 | |
ProteinModelPortal | Q68V28 | |
BindingDB | Q68V28 | |
MGI | MGI:98246 | |
ChiTaRS | Scn1a | |
Bgee | Q68V28 | |
ExpressionAtlas | Q68V28 | |
Genevestigator | Q68V28 | |
GO | GO:0030424 GO:0043194 GO:0014704 GO:0016020 GO:0043025 GO:0033268 GO:0034706 GO:0030315 GO:0005267 GO:0005248 GO:0001508 GO:0007628 GO:0086010 GO:0050884 GO:0019228 GO:0019227 GO:0042391 GO:0035725 GO:0006814 | |
Gene3D | 1.20.120.350 | |
InterPro | IPR027359 IPR005821 IPR003091 | |
Pfam | PF00520 | |
PRINTS | PR00169 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0006814 |
sodium ion transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005248 |
voltage-gated sodium channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050966 |
detection of mechanical stimulus involved in sensory perception of pain |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0030018 |
Z disc |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0086010 |
membrane depolarization during action potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000004140 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035725 |
sodium ion transmembrane transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0264255 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0030424 |
axon |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108029 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019228 |
neuronal action potential |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98246 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:102965 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005248 |
voltage-gated sodium channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0264255 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0001518 |
voltage-gated sodium channel complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000004137 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0099056 |
integral component of presynaptic membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69364 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0086002 |
cardiac muscle cell action potential involved in contraction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050884 |
neuromuscular process controlling posture |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3665322 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0050884 |
neuromuscular process controlling posture |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3665322 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0043194 |
axon initial segment |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0042391 |
regulation of membrane potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3665322 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0034706 |
sodium channel complex |
ECO:0000353 |
physical interaction evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0033268 |
node of Ranvier |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:35235)|part_of:(EMAPA:35253) |
Seeded From UniProt |
complete | ||
enables |
GO:0031402 |
sodium ion binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69364 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0030424 |
axon |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0030424 |
axon |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0030315 |
T-tubule |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0019228 |
neuronal action potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3665322 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0019228 |
neuronal action potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3665322 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0019228 |
neuronal action potential |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69364 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0019227 |
neuronal action potential propagation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3713733 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0016604 |
nuclear body |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0014704 |
intercalated disc |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007628 |
adult walking behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3665322 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007628 |
adult walking behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3713733 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0006814 |
sodium ion transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3665322 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0006814 |
sodium ion transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3665322 |
P |
|
Seeded From UniProt |
complete | |
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69364 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005248 |
voltage-gated sodium channel activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3665322 |
F |
|
Seeded From UniProt |
complete | |
enables |
GO:0005248 |
voltage-gated sodium channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69364 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0001518 |
voltage-gated sodium channel complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:69364 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001508 |
action potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3665322 |
P |
|
Seeded From UniProt |
complete | |
involved_in |
GO:0086002 |
cardiac muscle cell action potential involved in contraction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P35498 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0016604 |
nuclear body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P35498 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P35498 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P35498 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0001518 |
voltage-gated sodium channel complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005216 |
ion channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005248 |
voltage-gated sodium channel activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006811 |
ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006814 |
sodium ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055085 |
transmembrane transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034765 |
regulation of ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006814 |
sodium ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005272 |
sodium channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005244 |
voltage-gated ion channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Osteen, JD et al. (2016) Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain. Nature 534 494-9 PubMed GONUTS page
- ↑ Lopez-Santiago, LF et al. (2007) Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J. Mol. Cell. Cardiol. 43 636-47 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Kalume, F et al. (2007) Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy. J. Neurosci. 27 11065-74 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Yu, FH et al. (2006) Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat. Neurosci. 9 1142-9 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Ogiwara, I et al. (2007) Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J. Neurosci. 27 5903-14 PubMed GONUTS page
- ↑ Malhotra, JD et al. (2004) Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes. J. Biol. Chem. 279 40748-54 PubMed GONUTS page
- ↑ 8.0 8.1 Haufe, V et al. (2005) Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart. J. Physiol. (Lond.) 564 683-96 PubMed GONUTS page
- ↑ Brunham, LR et al. (2007) Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat. Med. 13 340-7 PubMed GONUTS page
- ↑ Planells-Cases, R et al. (2000) Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice. Biophys. J. 78 2878-91 PubMed GONUTS page
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