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MOUSE:PTPRJ
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Ptprj (synonyms: Byp, Scc1) | |
Protein Name(s) | Receptor-type tyrosine-protein phosphatase eta
Protein-tyrosine phosphatase eta R-PTP-eta HPTP beta-like tyrosine phosphatase Protein-tyrosine phosphatase receptor type J R-PTP-J Susceptibility to colon cancer 1 | |
External Links | ||
UniProt | Q64455 | |
EMBL | D45212 AY038877 AY038861 AY038891 AY039232 DQ133576 AK147318 AK147556 | |
PIR | S68700 | |
RefSeq | NP_033008.3 | |
UniGene | Mm.330393 | |
ProteinModelPortal | Q64455 | |
SMR | Q64455 | |
IntAct | Q64455 | |
STRING | 10090.ENSMUSP00000129592 | |
iPTMnet | Q64455 | |
PhosphoSite | Q64455 | |
EPD | Q64455 | |
MaxQB | Q64455 | |
PaxDb | Q64455 | |
PRIDE | Q64455 | |
DNASU | 19271 | |
GeneID | 19271 | |
KEGG | mmu:19271 | |
CTD | 5795 | |
MGI | MGI:104574 | |
eggNOG | KOG0791 COG5599 | |
HOGENOM | HOG000232054 | |
HOVERGEN | HBG053761 | |
InParanoid | Q64455 | |
KO | K05698 | |
ChiTaRS | Ptprj | |
PRO | PR:Q64455 | |
Proteomes | UP000000589 | |
Bgee | Q64455 | |
CleanEx | MM_PTPRJ | |
GO | GO:0009986 GO:0005911 GO:0070062 GO:0001772 GO:0016021 GO:0005886 GO:0032587 GO:0008013 GO:0070097 GO:0045295 GO:0051019 GO:0016791 GO:0005161 GO:0019901 GO:0004725 GO:0007596 GO:0007507 GO:0030308 GO:0030336 GO:0008285 GO:0042059 GO:0043407 GO:0010642 GO:0051898 GO:2000272 GO:0050860 GO:0043116 GO:0048709 GO:0035335 GO:0048008 GO:0050918 GO:0045785 GO:0001954 GO:0051894 GO:0010759 GO:0010572 GO:0051897 GO:0030155 GO:0001570 | |
Gene3D | 2.60.40.10 3.90.190.10 | |
InterPro | IPR003961 IPR013783 IPR029021 IPR000242 IPR016130 IPR003595 IPR000387 | |
Pfam | PF00041 PF00102 | |
PRINTS | PR00700 | |
SMART | SM00060 SM00194 SM00404 | |
SUPFAM | SSF49265 SSF52799 | |
PROSITE | PS50853 PS00383 PS50056 PS50055 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0046627 |
negative regulation of insulin receptor signaling pathway |
ECO:0000315 |
P |
Figure 4A: Mice with Ptprj expression knocked down show increased tyrosine phosphorylation of the insulin receptor in the presence of insulin. In addition, figure 4B shows that mice with Ptprj expression knocked down show increased activation via phosphorylation of Akt, a downstream effector of insulin signaling. |
complete | |||||
GO:1990264 |
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity |
ECO:0000315 |
P |
Figure 4A: Mice with Ptprj expression knocked down show increased tyrosine phosphorylation of the insulin receptor (a member of the receptor protein tyrosine kinase superfamily) in the presence of insulin. In addition, figure 4B shows that mice with Ptprj expression knocked down show increased phosphorylation of Akt, a downstream effector of insulin signaling. |
complete | |||||
GO:0042593 |
glucose homeostasis |
ECO:0000315 |
P |
Figure 5A: Mice with Ptprj expression knocked down show decreased effect of injected glucose on blood glucose levels. |
complete | |||||
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000315 |
P |
Figure 4A: Mice with Ptprj expression knocked down show increased tyrosine phosphorylation of the insulin receptor in the presence of insulin. |
complete | |||||
involved_in |
GO:0032760 |
positive regulation of tumor necrosis factor production |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:1905451 |
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0043410 |
positive regulation of MAPK cascade |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:P25911) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035584 |
calcium-mediated signaling using intracellular calcium source |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
involved_in |
GO:0030183 |
B cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
causally_upstream_of:(GO:0050853) |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000272 |
negative regulation of signaling receptor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051898 |
negative regulation of protein kinase B signaling |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051894 |
positive regulation of focal adhesion assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050860 |
negative regulation of T cell receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048008 |
platelet-derived growth factor receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043407 |
negative regulation of MAP kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042059 |
negative regulation of epidermal growth factor receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0032587 |
ruffle membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030336 |
negative regulation of cell migration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016791 |
phosphatase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010759 |
positive regulation of macrophage chemotaxis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010642 |
negative regulation of platelet-derived growth factor receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010572 |
positive regulation of platelet activation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007596 |
blood coagulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005911 |
cell-cell junction |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001954 |
positive regulation of cell-matrix adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0001772 |
immunological synapse |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0070097 |
delta-catenin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051898 |
negative regulation of protein kinase B signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051897 |
positive regulation of protein kinase B signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051894 |
positive regulation of focal adhesion assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051019 |
mitogen-activated protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050918 |
positive chemotaxis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050860 |
negative regulation of T cell receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0048709 |
oligodendrocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0048008 |
platelet-derived growth factor receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045785 |
positive regulation of cell adhesion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0045295 |
gamma-catenin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043407 |
negative regulation of MAP kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043116 |
negative regulation of vascular permeability |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0042059 |
negative regulation of epidermal growth factor receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030336 |
negative regulation of cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030308 |
negative regulation of cell growth |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030155 |
regulation of cell adhesion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016791 |
phosphatase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010642 |
negative regulation of platelet-derived growth factor receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0009986 |
cell surface |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008013 |
beta-catenin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007507 |
heart development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2653313 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005911 |
cell-cell junction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005161 |
platelet-derived growth factor receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0001772 |
immunological synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001570 |
vasculogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2653313 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016791 |
phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0032587 |
ruffle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Shintani, T et al. (2015) The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. J. Biochem. 158 235-43 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Zhu, JW et al. (2008) Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity 28 183-96 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Grazia Lampugnani, M et al. (2003) Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J. Cell Biol. 161 793-804 PubMed GONUTS page
- ↑ 4.0 4.1 Lin, J & Weiss, A (2003) The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J. Cell Biol. 162 673-82 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Jandt, E et al. (2003) The protein-tyrosine phosphatase DEP-1 modulates growth factor-stimulated cell migration and cell-matrix adhesion. Oncogene 22 4175-85 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Dave, RK et al. (2009) CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages. Exp. Cell Res. 315 1734-44 PubMed GONUTS page
- ↑ 7.0 7.1 Senis, YA et al. (2009) The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood 113 4942-54 PubMed GONUTS page
- ↑ Gobert, RP et al. (2009) Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol. Cell. Biol. 29 1538-53 PubMed GONUTS page
- ↑ 9.0 9.1 Takahashi, T et al. (2003) A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development. Mol. Cell. Biol. 23 1817-31 PubMed GONUTS page
b
c
m
n
- GO:0030308 ! negative regulation of cell growth
- GO:0043116 ! negative regulation of vascular permeability
- GO:0046627 ! negative regulation of insulin receptor signaling pathway
- GO:0030336 ! negative regulation of cell migration
- GO:0008285 ! negative regulation of cell population proliferation
- GO:2000272 ! negative regulation of signaling receptor activity
- GO:0051898 ! negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0050860 ! negative regulation of T cell receptor signaling pathway
- GO:0043407 ! negative regulation of MAP kinase activity
- GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway
- GO:0010642 ! negative regulation of platelet-derived growth factor receptor signaling pathway
o
p
- GO:1990264 ! peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
- GO:0035335 ! peptidyl-tyrosine dephosphorylation
- GO:0016791 ! phosphatase activity
- GO:0004721 ! phosphoprotein phosphatase activity
- GO:0005886 ! plasma membrane
- GO:0005161 ! platelet-derived growth factor receptor binding
- GO:0048008 ! platelet-derived growth factor receptor signaling pathway
- GO:0050918 ! positive chemotaxis
- GO:0001954 ! positive regulation of cell-matrix adhesion
- GO:0032760 ! positive regulation of tumor necrosis factor production
- GO:1905451 ! positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
- GO:0043410 ! positive regulation of MAPK cascade
- GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
- GO:0051897 ! positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0045785 ! positive regulation of cell adhesion
- GO:0010759 ! positive regulation of macrophage chemotaxis
- GO:0051894 ! positive regulation of focal adhesion assembly
- GO:0010572 ! positive regulation of platelet activation
- GO:0006470 ! protein dephosphorylation
- GO:0019901 ! protein kinase binding
- GO:0004725 ! protein tyrosine phosphatase activity