MOUSE:PTPRJ

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ptprj (synonyms: Byp, Scc1)
Protein Name(s)	Receptor-type tyrosine-protein phosphatase eta Protein-tyrosine phosphatase eta R-PTP-eta HPTP beta-like tyrosine phosphatase Protein-tyrosine phosphatase receptor type J R-PTP-J Susceptibility to colon cancer 1
External Links
UniProt	Q64455
EMBL	D45212 AY038877 AY038861 AY038891 AY039232 DQ133576 AK147318 AK147556
PIR	S68700
RefSeq	NP_033008.3
UniGene	Mm.330393
ProteinModelPortal	Q64455
SMR	Q64455
IntAct	Q64455
STRING	10090.ENSMUSP00000129592
iPTMnet	Q64455
PhosphoSite	Q64455
EPD	Q64455
MaxQB	Q64455
PaxDb	Q64455
PRIDE	Q64455
DNASU	19271
GeneID	19271
KEGG	mmu:19271
CTD	5795
MGI	MGI:104574
eggNOG	KOG0791 COG5599
HOGENOM	HOG000232054
HOVERGEN	HBG053761
InParanoid	Q64455
KO	K05698
ChiTaRS	Ptprj
PRO	PR:Q64455
Proteomes	UP000000589
Bgee	Q64455
CleanEx	MM_PTPRJ
GO	GO:0009986 GO:0005911 GO:0070062 GO:0001772 GO:0016021 GO:0005886 GO:0032587 GO:0008013 GO:0070097 GO:0045295 GO:0051019 GO:0016791 GO:0005161 GO:0019901 GO:0004725 GO:0007596 GO:0007507 GO:0030308 GO:0030336 GO:0008285 GO:0042059 GO:0043407 GO:0010642 GO:0051898 GO:2000272 GO:0050860 GO:0043116 GO:0048709 GO:0035335 GO:0048008 GO:0050918 GO:0045785 GO:0001954 GO:0051894 GO:0010759 GO:0010572 GO:0051897 GO:0030155 GO:0001570
Gene3D	2.60.40.10 3.90.190.10
InterPro	IPR003961 IPR013783 IPR029021 IPR000242 IPR016130 IPR003595 IPR000387
Pfam	PF00041 PF00102
PRINTS	PR00700
SMART	SM00060 SM00194 SM00404
SUPFAM	SSF49265 SSF52799
PROSITE	PS50853 PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:26063811^[1]	ECO:0000315			P		Figure 4A: Mice with Ptprj expression knocked down show increased tyrosine phosphorylation of the insulin receptor in the presence of insulin. In addition, figure 4B shows that mice with Ptprj expression knocked down show increased activation via phosphorylation of Akt, a downstream effector of insulin signaling.	complete CACAO 12226
	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	PMID:26063811^[1]	ECO:0000315			P		Figure 4A: Mice with Ptprj expression knocked down show increased tyrosine phosphorylation of the insulin receptor (a member of the receptor protein tyrosine kinase superfamily) in the presence of insulin. In addition, figure 4B shows that mice with Ptprj expression knocked down show increased phosphorylation of Akt, a downstream effector of insulin signaling.	complete CACAO 12227
	GO:0042593	glucose homeostasis	PMID:26063811^[1]	ECO:0000315			P		Figure 5A: Mice with Ptprj expression knocked down show decreased effect of injected glucose on blood glucose levels.	complete CACAO 12228
	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:26063811^[1]	ECO:0000315			P		Figure 4A: Mice with Ptprj expression knocked down show increased tyrosine phosphorylation of the insulin receptor in the presence of insulin.	complete CACAO 12260
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:18249142^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P06800	P	occurs_in:(CL:0002476) regulates_o_occurs_in:(CL:0002476)	Seeded From UniProt	complete
involved_in	GO:1905451	positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	PMID:18249142^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P06800	P	occurs_in:(CL:0002476) regulates_o_occurs_in:(CL:0002476)	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:18249142^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P06800	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:18249142^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P06800	P	has_regulation_target:(UniProtKB:P25911)	Seeded From UniProt	complete
involved_in	GO:0035584	calcium-mediated signaling using intracellular calcium source	PMID:18249142^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P06800	P	occurs_in:(CL:0000236) occurs_in:(UBERON:0000029)	Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	PMID:18249142^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	causally_upstream_of:(GO:0050853)	Seeded From UniProt	complete
involved_in	GO:2000272	negative regulation of signaling receptor activity	PMID:12771128^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
involved_in	GO:0050860	negative regulation of T cell receptor signaling pathway	PMID:12913111^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	PMID:12833140^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	PMID:19268662^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:12833140^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12913	F		Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	PMID:19268662^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	PMID:12833140^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010572	positive regulation of platelet activation	PMID:19246339^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:12771128^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	PMID:19246339^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12913	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19268662^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:12771128^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001954	positive regulation of cell-matrix adhesion	PMID:12833140^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0001772	immunological synapse	PMID:12913111^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070097	delta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
enables	GO:0051019	mitogen-activated protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050918	positive chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050860	negative regulation of T cell receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048709	oligodendrocyte differentiation	PMID:19139271^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045785	positive regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
enables	GO:0045295	gamma-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043116	negative regulation of vascular permeability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030336	negative regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030155	regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	F		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:12588999^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2653313	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	C		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	F		Seeded From UniProt	complete
part_of	GO:0001772	immunological synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12913	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001570	vasculogenesis	PMID:12588999^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2653313	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR016130	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0301	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Shintani, T et al. (2015) The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. J. Biochem. 158 235-43 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Zhu, JW et al. (2008) Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity 28 183-96 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Grazia Lampugnani, M et al. (2003) Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J. Cell Biol. 161 793-804 PubMed GONUTS page
↑ ^4.0 ^4.1 Lin, J & Weiss, A (2003) The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J. Cell Biol. 162 673-82 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Jandt, E et al. (2003) The protein-tyrosine phosphatase DEP-1 modulates growth factor-stimulated cell migration and cell-matrix adhesion. Oncogene 22 4175-85 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Dave, RK et al. (2009) CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages. Exp. Cell Res. 315 1734-44 PubMed GONUTS page
↑ ^7.0 ^7.1 Senis, YA et al. (2009) The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood 113 4942-54 PubMed GONUTS page
↑ Gobert, RP et al. (2009) Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol. Cell. Biol. 29 1538-53 PubMed GONUTS page
↑ ^9.0 ^9.1 Takahashi, T et al. (2003) A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development. Mol. Cell. Biol. 23 1817-31 PubMed GONUTS page

[PMID:26063811-1] 1.0 ^1.1 ^1.2 ^1.3 Shintani, T et al. (2015) The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. J. Biochem. 158 235-43 PubMed GONUTS page

[PMID:18249142-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Zhu, JW et al. (2008) Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity 28 183-96 PubMed GONUTS page

[PMID:12771128-3] 3.0 ^3.1 ^3.2 Grazia Lampugnani, M et al. (2003) Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J. Cell Biol. 161 793-804 PubMed GONUTS page

[PMID:12913111-4] 4.0 ^4.1 Lin, J & Weiss, A (2003) The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J. Cell Biol. 162 673-82 PubMed GONUTS page

[PMID:12833140-5] 5.0 ^5.1 ^5.2 ^5.3 Jandt, E et al. (2003) The protein-tyrosine phosphatase DEP-1 modulates growth factor-stimulated cell migration and cell-matrix adhesion. Oncogene 22 4175-85 PubMed GONUTS page

[PMID:19268662-6] 6.0 ^6.1 ^6.2 Dave, RK et al. (2009) CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages. Exp. Cell Res. 315 1734-44 PubMed GONUTS page

[PMID:19246339-7] 7.0 ^7.1 Senis, YA et al. (2009) The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood 113 4942-54 PubMed GONUTS page

[PMID:19139271-8] Gobert, RP et al. (2009) Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol. Cell. Biol. 29 1538-53 PubMed GONUTS page

[PMID:12588999-9] 9.0 ^9.1 Takahashi, T et al. (2003) A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development. Mol. Cell. Biol. 23 1817-31 PubMed GONUTS page

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MOUSE:PTPRJ

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