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MOUSE:PTPRD

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ptprd
Protein Name(s) Receptor-type tyrosine-protein phosphatase delta

Protein-tyrosine phosphatase delta R-PTP-delta

External Links
UniProt Q64487
EMBL D13903
D13905
D13904
AF326559
AF326560
AL844848
AL845517
AL929181
Z23051
PIR C54689
D54689
RefSeq NP_035341.2
UniGene Mm.184021
Mm.403663
Mm.477158
Mm.489057
ProteinModelPortal Q64487
SMR Q64487
IntAct Q64487
MINT MINT-129768
PhosphoSite Q64487
MaxQB Q64487
PaxDb Q64487
PRIDE Q64487
Ensembl ENSMUST00000107289
GeneID 19266
KEGG mmu:19266
UCSC uc008tjl.1
CTD 5789
MGI MGI:97812
eggNOG COG5599
GeneTree ENSGT00760000118900
HOGENOM HOG000010250
HOVERGEN HBG053758
InParanoid Q64487
KO K06777
OMA FNDRREI
OrthoDB EOG7M98FB
ChiTaRS Ptprd
NextBio 296140
PRO PR:Q64487
Proteomes UP000000589
Bgee Q64487
CleanEx MM_PTPRD
ExpressionAtlas Q64487
Genevestigator Q64487
GO GO:0016021
GO:0050839
GO:0004725
GO:0005102
GO:0007157
GO:0030182
GO:0050775
GO:0097105
Gene3D 2.60.40.10
3.90.190.10
InterPro IPR003961
IPR007110
IPR013783
IPR013098
IPR003598
IPR029021
IPR000387
IPR016130
IPR000242
Pfam PF00041
PF07679
PF00102
PRINTS PR00700
SMART SM00060
SM00408
SM00194
SUPFAM SSF49265
SSF52799
PROSITE PS50853
PS50835
PS00383
PS50056
PS50055

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0007157

heterophilic cell-cell adhesion

PMID:21940441[1]

ECO:0000314

P

Figure 4C, HEK293T cell transfected with mouse Il1rapl1 labeled with EGFP and Receptor-type tyrosine-protein phosphatase delta (R-PTP-delta)labeled with RFP. Cell aggregated into large clumps suggesting that both Il1rapl1 and R-PTP-delta function as heterophilic cell adhesion molecules. But cell expressing either Il1rapl1 or R-PTP-delta did not show homophilic aggregation.

complete
CACAO 2158

GO:0097105

presynaptic membrane assembly

PMID:21940441[1]

ECO:0000315

P

Transfected HEK293T with IL1RAPL-1 co-cultured with knockout Ptprd mouse cortical neurons. Bassoon marker (presynaptic marker at the presynaptic active zone which is part of the plasma membrane of the presynaptic neuron) was detected in wild type Ptprd mouse but in homozygous (figure 6A) and heterozygous (figure 6D) knockout Ptprd mice, bassoon expression was not detected.

complete
CACAO 2160

GO:0050775

positive regulation of dendrite morphogenesis

PMID:21940441[1]

ECO:0000315

P

Labeled neurons with FLAG-IL1RAPL1 co-cultured with mouse wild type or knockout Ptprd cortical neurons. There was an increase in number of dendritic protrusion with shank2 staining figure 7A-C in wild type but this increase was not seen in knockout Ptprd mice. Similar results seen in figure 9A-D, showed decrease in spines density of basal dendrites in knockout Ptprd mice.

complete
CACAO 2161

involved_in

GO:0051965

positive regulation of synapse assembly

PMID:25908590[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051965

positive regulation of synapse assembly

PMID:25989451[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050775

positive regulation of dendrite morphogenesis

PMID:21940441[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097105

presynaptic membrane assembly

PMID:21940441[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

PMID:21940441[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097105

presynaptic membrane assembly

PMID:21940441[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050839

cell adhesion molecule binding

PMID:21940441[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P0C192

F

Seeded From UniProt

complete

involved_in

GO:0050775

positive regulation of dendrite morphogenesis

PMID:21940441[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:21940441[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

PMID:21940441[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:21940441[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P59823

F

Seeded From UniProt

complete

involved_in

GO:0099151

regulation of postsynaptic density assembly

PMID:22357843[4]

ECO:0006063

over expression analysis evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0000956)

Seeded From UniProt

complete

involved_in

GO:0099151

regulation of postsynaptic density assembly

PMID:22357843[4]

ECO:0005589

confocal microscopy evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0000956)

Seeded From UniProt

complete

part_of

GO:0099056

integral component of presynaptic membrane

PMID:29024665[5]

ECO:0005589

confocal microscopy evidence used in manual assertion

C

  • part_of:(GO:0098978)
  • part_of:(UBERON:0000061)
  • part_of:(UBERON:0000966)

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:22357843[4]

ECO:0006063

over expression analysis evidence used in manual assertion

C

  • part_of:(UBERON:0000061)
  • part_of:(UBERON:0000956)

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:29024665[5]

ECO:0005589

confocal microscopy evidence used in manual assertion

C

part_of:(UBERON:0000966)

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:22357843[4]

ECO:0005589

confocal microscopy evidence used in manual assertion

C

  • part_of:(UBERON:0000061)
  • part_of:(UBERON:0000956)

Seeded From UniProt

complete

part_of

GO:0098686

hippocampal mossy fiber to CA3 synapse

PMID:10856223[6]

ECO:0001225

knockout evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0098685

Schaffer collateral - CA1 synapse

PMID:10856223[6]

ECO:0001225

knockout evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050804

modulation of chemical synaptic transmission

PMID:10856223[6]

ECO:0001225

knockout evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050804

modulation of chemical synaptic transmission

PMID:10856223[6]

ECO:0001225

knockout evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050776

regulation of immune response

PMID:24843164[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158795

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046426

negative regulation of receptor signaling pathway via JAK-STAT

PMID:24843164[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158795

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000242
InterPro:IPR016130

F

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000242

P

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000387
InterPro:IPR016130

P

Seeded From UniProt

complete

enables

GO:0016791

phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000387

F

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.48

F

Seeded From UniProt

complete

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Yoshida, T et al. (2011) IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ. J. Neurosci. 31 13485-99 PubMed GONUTS page
  2. ↑ Yamagata, A et al. (2015) Mechanisms of splicing-dependent trans-synaptic adhesion by PTPδ-IL1RAPL1/IL-1RAcP for synaptic differentiation. Nat Commun 6 6926 PubMed GONUTS page
  3. ↑ Yamagata, A et al. (2015) Structure of Slitrk2-PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion. Sci Rep 5 9686 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Yoshida, T et al. (2012) Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule. J. Neurosci. 32 2588-600 PubMed GONUTS page
  5. ↑ 5.0 5.1 Farhy-Tselnicker, I et al. (2017) Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation. Neuron 96 428-445.e13 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Uetani, N et al. (2000) Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice. EMBO J. 19 2775-85 PubMed GONUTS page
  7. ↑ 7.0 7.1 Ortiz, B et al. (2014) Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis. Proc. Natl. Acad. Sci. U.S.A. 111 8149-54 PubMed GONUTS page
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