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MOUSE:PTPRB
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Ptprb | |
| Protein Name(s) | Receptor-type tyrosine-protein phosphatase beta
Protein-tyrosine phosphatase beta R-PTP-beta Vascular endothelial protein tyrosine phosphatase VE-PTP | |
| External Links | ||
| UniProt | B2RU80 | |
| EMBL | AY077755 AK147439 AK147668 CH466539 BC141006 BC145111 | |
| CCDS | CCDS36063.1 | |
| RefSeq | NP_084204.2 | |
| UniGene | Mm.37213 Mm.489025 | |
| ProteinModelPortal | B2RU80 | |
| SMR | B2RU80 | |
| IntAct | B2RU80 | |
| MINT | MINT-8298798 | |
| STRING | 10090.ENSMUSP00000089805 | |
| iPTMnet | B2RU80 | |
| PhosphoSitePlus | B2RU80 | |
| MaxQB | B2RU80 | |
| PaxDb | B2RU80 | |
| PeptideAtlas | B2RU80 | |
| PRIDE | B2RU80 | |
| Ensembl | ENSMUST00000092167 | |
| GeneID | 19263 | |
| KEGG | mmu:19263 | |
| UCSC | uc007hbv.2 | |
| CTD | 5787 | |
| MGI | MGI:97809 | |
| eggNOG | KOG0791 COG5599 | |
| GeneTree | ENSGT00870000136384 | |
| HOGENOM | HOG000060224 | |
| HOVERGEN | HBG053759 | |
| InParanoid | B2RU80 | |
| KO | K05694 | |
| OMA | RVYQTNY | |
| OrthoDB | EOG091G00JF | |
| PhylomeDB | B2RU80 | |
| TreeFam | TF351926 | |
| Reactome | [www.reactome.org/content/detail/R-MMU-6798695 R-MMU-6798695] | |
| ChiTaRS | Ptprb | |
| PRO | PR:B2RU80 | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000020154 | |
| Genevisible | B2RU80 | |
| GO | GO:0016021 GO:0043235 GO:0004725 GO:0001525 GO:0016311 | |
| CDD | cd00063 | |
| Gene3D | 2.60.40.10 3.90.190.10 | |
| InterPro | IPR003961 IPR013783 IPR029021 IPR000242 IPR016130 IPR003595 IPR000387 | |
| Pfam | PF00041 PF00102 | |
| PRINTS | PR00700 | |
| SMART | SM00060 SM00194 SM00404 | |
| SUPFAM | SSF49265 SSF52799 | |
| PROSITE | PS50853 PS00383 PS50056 PS50055 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000314 |
P |
Figure 1B: mouse Ptprb dephosphorylates tyrosine-phosphorylated IR in vitro |
complete | |||||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:1990264 |
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity |
ECO:0000314 |
P |
Figure 2B and 2C: mouse Ptprb dephosphorylates tyrosine 1146 in the activation loop of the insulin receptor (a member of the receptor protein tyrosine kinase superfamily) in HEK293T (human embryonic kidney) cells |
complete | |||||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043235 |
receptor complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0016311 |
dephosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004725 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043235 |
receptor complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23467 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P23467 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006470 |
protein dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016311 |
dephosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016791 |
phosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004725 |
protein tyrosine phosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004721 |
phosphoprotein phosphatase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Shintani, T et al. (2015) The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. J. Biochem. 158 235-43 PubMed GONUTS page
- ↑ Fachinger, G et al. (1999) Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene 18 5948-53 PubMed GONUTS page
- ↑ Nawroth, R et al. (2002) VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J. 21 4885-95 PubMed GONUTS page
- ↑ Bäumer, S et al. (2006) Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood 107 4754-62 PubMed GONUTS page
- ↑ Dominguez, MG et al. (2007) Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 104 3243-8 PubMed GONUTS page
- ↑ Winderlich, M et al. (2009) VE-PTP controls blood vessel development by balancing Tie-2 activity. J. Cell Biol. 185 657-71 PubMed GONUTS page
- ↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
g
p
- GO:1990264 ! peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
- GO:0035335 ! peptidyl-tyrosine dephosphorylation
- GO:0016791 ! phosphatase activity
- GO:0004721 ! phosphoprotein phosphatase activity
- GO:0006470 ! protein dephosphorylation
- GO:0004725 ! protein tyrosine phosphatase activity
