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MOUSE:PTCD1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ptcd1
Protein Name(s) Pentatricopeptide repeat-containing protein 1, mitochondrial
External Links
UniProt Q8C2E4
EMBL AK088764
AK171484
BC004766
BC083097
CCDS CCDS19858.1
RefSeq NP_598496.3
UniGene Mm.277413
Mm.332840
Mm.474456
ProteinModelPortal Q8C2E4
IntAct Q8C2E4
MINT Q8C2E4
STRING 10090.ENSMUSP00000031628
PhosphoSitePlus Q8C2E4
MaxQB Q8C2E4
PaxDb Q8C2E4
PRIDE Q8C2E4
DNASU 71799
Ensembl ENSMUST00000031628
GeneID 71799
KEGG mmu:71799
UCSC uc009amh.2
CTD 26024
MGI MGI:1919049
eggNOG KOG4197
ENOG410Z7Z7
GeneTree ENSGT00390000015597
HOGENOM HOG000237315
HOVERGEN HBG053748
InParanoid Q8C2E4
KO K17710
OMA FRAYYKQ
OrthoDB EOG091G02E4
TreeFam TF324792
PRO PR:Q8C2E4
Proteomes UP000000589
Bgee ENSMUSG00000029624
CleanEx MM_PTCD1
ExpressionAtlas Q8C2E4
Genevisible Q8C2E4
GO GO:0005759
GO:0000049
GO:0042780
Gene3D 1.25.40.10
InterPro IPR002885
IPR011990
Pfam PF13041
PF13812
TIGRFAMs TIGR00756
PROSITE PS51375

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0032543

mitochondrial translation

PMID:29617655[1]

ECO:0000315

P

In this paper, they measured de novo mitochondrial protein synthesis of the 13 mtDNA-encoded respiratory complex subunits and showed a dramatic loss of translation in the Ptcd1 knockout mice compared to controls in both tissues (Figures 3A and S1A), indicating that PTCD1 is essential for mitochondrial protein synthesis.

complete
CACAO 13293

involved_in

GO:0042780

tRNA 3'-end processing

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75127

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:A2VD13

C

Seeded From UniProt

complete

enables

GO:0000049

tRNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O75127

F

Seeded From UniProt

complete

involved_in

GO:0042780

tRNA 3'-end processing

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001165391
UniProtKB:O75127

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001165391
RGD:1311473

C

Seeded From UniProt

complete

enables

GO:0000049

tRNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001165391
UniProtKB:O75127

F

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1311473

C

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A2VD13
ensembl:ENSRNOP00000068093

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

involved_in

GO:0008033

tRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0819

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Perks, KL et al. (2018) PTCD1 Is Required for 16S rRNA Maturation Complex Stability and Mitochondrial Ribosome Assembly. Cell Rep 23 127-142 PubMed GONUTS page
  2. 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page