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MOUSE:PRL

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Prl
Protein Name(s) Prolactin

PRL

External Links
UniProt P06879
EMBL X02892
X04418
AK017521
AK017579
UniGene Mm.1270
ProteinModelPortal P06879
STRING 10090.ENSMUSP00000105998
PhosphoSite P06879
PaxDb P06879
PRIDE P06879
MGI MGI:97762
eggNOG NOG47376
HOVERGEN HBG104895
InParanoid P06879
Reactome REACT_198561
REACT_198563
REACT_198614
ChiTaRS Prl
PRO PR:P06879
Proteomes UP000000589
Bgee P06879
CleanEx MM_PRL
ExpressionAtlas P06879
Genevestigator P06879
GO GO:0005576
GO:0030141
GO:0005179
GO:0032870
GO:0007623
GO:0007595
GO:0030879
GO:0042711
GO:0033555
GO:0042698
GO:0007567
GO:0008284
GO:0050679
GO:0046427
GO:0046425
GO:0030278
GO:0042493
GO:0032355
GO:0045471
GO:0032496
GO:0007584
GO:0007262
Gene3D 1.20.1250.10
InterPro IPR009079
IPR012351
IPR001400
IPR018116
PANTHER PTHR11417
Pfam PF00103
PRINTS PR00836
SUPFAM SSF47266
PROSITE PS00338

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:1903489

positive regulation of lactation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151833
UniProtKB:P01239

P

Seeded From UniProt

complete

involved_in

GO:0046427

positive regulation of receptor signaling pathway via JAK-STAT

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97762
PANTHER:PTN000151829
UniProtKB:P01236
UniProtKB:P01241

P

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151829
UniProtKB:P01246

P

Seeded From UniProt

complete

involved_in

GO:0030879

mammary gland development

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97762
PANTHER:PTN000151833

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341833
MGI:MGI:97762
PANTHER:PTN000151831
RGD:2428
RGD:3403

P

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151833
RGD:2516
RGD:708348

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341833
MGI:MGI:1858413
MGI:MGI:95707
MGI:MGI:97606
MGI:MGI:97607
MGI:MGI:97618
MGI:MGI:97619
PANTHER:PTN000151829
RGD:2429
RGD:2686
UniProtKB:P01238
UniProtKB:P01239
UniProtKB:P01241
UniProtKB:P01246
UniProtKB:P08998
UniProtKB:P14676

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341833
MGI:MGI:97618
MGI:MGI:97619
PANTHER:PTN000151829
RGD:2686

F

Seeded From UniProt

complete

enables

GO:0005148

prolactin receptor binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151833
RGD:2428

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01236

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050679

positive regulation of epithelial cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3403

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046427

positive regulation of receptor signaling pathway via JAK-STAT

PMID:12388746[2]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:102709

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046427

positive regulation of receptor signaling pathway via JAK-STAT

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01236

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046425

regulation of receptor signaling pathway via JAK-STAT

PMID:12147240[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042711

maternal behavior

PMID:23071095[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1924378
MGI:MGI:95824

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030879

mammary gland development

PMID:18425773[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:105088

P

results_in_development_of:(EMAPA:17759)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030278

regulation of ossification

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3403

P

Seeded From UniProt

complete

part_of

GO:0030141

secretory granule

PMID:9247267[6]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:35998)
  • part_of:(CL:0000439)

Seeded From UniProt

complete

part_of

GO:0030141

secretory granule

PMID:16219686[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030141

secretory granule

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3403

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

PMID:9247268[8]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:94924

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3403

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3403

C

Seeded From UniProt

complete

enables

GO:0005148

prolactin receptor binding

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01240

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001937

negative regulation of endothelial cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01236

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001400
InterPro:IPR018116

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001400
InterPro:IPR018116

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

PMID:12147240[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

involved_in

GO:0007595

lactation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0421

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ Park, DS et al. (2002) Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade. Mol. Biol. Cell 13 3416-30 PubMed GONUTS page
  3. ↑ 3.0 3.1 Olsen, H et al. (2002) Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells. Biochem. Biophys. Res. Commun. 296 139-44 PubMed GONUTS page
  4. ↑ Martyn, AC et al. (2012) Luman/CREB3 recruitment factor regulates glucocorticoid receptor activity and is essential for prolactin-mediated maternal instinct. Mol. Cell. Biol. 32 5140-50 PubMed GONUTS page
  5. ↑ Strizzi, L et al. (2008) Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J. Cell. Physiol. 216 824-34 PubMed GONUTS page
  6. ↑ Kelly, MA et al. (1997) Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron 19 103-13 PubMed GONUTS page
  7. ↑ Hosaka, M et al. (2005) Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules. J. Cell. Sci. 118 4785-95 PubMed GONUTS page
  8. ↑ Saiardi, A et al. (1997) Antiproliferative role of dopamine: loss of D2 receptors causes hormonal dysfunction and pituitary hyperplasia. Neuron 19 115-26 PubMed GONUTS page
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