MOUSE:PRIO

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Prnp (synonyms: Prn-p, Prp)
Protein Name(s)	Major prion protein PrP PrP27-30 PrP33-35C
External Links
UniProt	P04925
EMBL	M18070 M18071 M13685 U29186 BC006703 M30384
CCDS	CCDS16766.1
PIR	A29669
RefSeq	NP_001265185.1 NP_035300.1
UniGene	Mm.648
PDB	1AG2 1XYX 1Y15 1Y16 2K5O 2KFM 2KFO 2KU5 2KU6 2L1D 2L1E 2L1H 2L1K 2L39 2L40 3NVG 3NVH 4H88 4J8R 4MA7 4MA8
PDBsum	1AG2 1XYX 1Y15 1Y16 2K5O 2KFM 2KFO 2KU5 2KU6 2L1D 2L1E 2L1H 2L1K 2L39 2L40 3NVG 3NVH 4H88 4J8R 4MA7 4MA8
DisProt	DP00265
ProteinModelPortal	P04925
SMR	P04925
BioGrid	202389
DIP	DIP-4N
IntAct	P04925
MINT	MINT-214988
BindingDB	P04925
ChEMBL	CHEMBL3698
PhosphoSite	P04925
MaxQB	P04925
PaxDb	P04925
PRIDE	P04925
Ensembl	ENSMUST00000091288
GeneID	19122
KEGG	mmu:19122
UCSC	uc008mly.2
CTD	5621
MGI	MGI:97769
eggNOG	NOG41716
HOGENOM	HOG000232077
HOVERGEN	HBG008260
InParanoid	P04925
KO	K05634
OMA	QVYYRPV
OrthoDB	EOG7DRJ4Q
PhylomeDB	P04925
TreeFam	TF105188
Reactome	REACT_236183
ChiTaRS	Prnp
EvolutionaryTrace	P04925
NextBio	295714
PMAP-CutDB	P04925
PRO	PR:P04925
Proteomes	UP000000589
Bgee	P04925
CleanEx	MM_PRNP
ExpressionAtlas	P04925
Genevestigator	P04925
GO	GO:0031225 GO:0005783 GO:0070062 GO:0005794 GO:0016020 GO:0045121 GO:0005886 GO:0005507 GO:0042802 GO:0006878 GO:0007611 GO:0046007 GO:0043066 GO:0070885 GO:0032689 GO:0032700 GO:0032703 GO:0001933 GO:0043433 GO:0050860 GO:0006139 GO:0051260 GO:1901379 GO:0032880 GO:0046686 GO:0046688 GO:0006979
Gene3D	1.10.790.10
InterPro	IPR000817 IPR022416 IPR025860
PANTHER	PTHR11522
Pfam	PF00377 PF11587
PRINTS	PR00341
SMART	SM00157
SUPFAM	SSF54098
PROSITE	PS00291 PS00706

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043195	terminal bouton	PMID:15262264^[1]	ECO:0000314			C		Figure 6A, D and E "terminal bouton" is a synonym for "presynaptic terminal"	complete CACAO 11094
part_of	GO:0045121	membrane raft	PMID:17573534^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902951	negative regulation of dendritic spine maintenance	PMID:24012003^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	regulates_o_occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:1902992	negative regulation of amyloid precursor protein catabolic process	PMID:17573534^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12023	P	has_output:(UniProtKB:P12023:PRO_0000000116) has_regulation_target:(UniProtKB:P56818) regulates_o_occurs_in:(GO:0045121)	Seeded From UniProt	complete
enables	GO:1903135	cupric ion binding	PMID:19381258^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902951	negative regulation of dendritic spine maintenance	PMID:22820466^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P39688,UniProtKB:Q01097	P	occurs_in:(CL:0002609) part_of:(GO:1904646)	Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:22820466^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P39688,UniProtKB:Q01097	P	occurs_in:(CL:0002609) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:1905664	regulation of calcium ion import across plasma membrane	PMID:22820466^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P39688	P	occurs_in:(CL:0002609) causally_upstream_of:(GO:1901216) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:0090314	positive regulation of protein targeting to membrane	PMID:22820466^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P39688	P	occurs_in:(CL:0002609) part_of:(GO:1904645) has_regulation_target:(UniProtKB:Q01097) regulates:(GO:0098703)	Seeded From UniProt	complete
involved_in	GO:1900449	regulation of glutamate receptor signaling pathway	PMID:22820466^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P39688	P	occurs_in:(CL:0002609)	Seeded From UniProt	complete
enables	GO:0005539	glycosaminoglycan binding	PMID:17573534^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	directly_positively_regulates:(GO:0002020) negatively_regulates:(GO:0042987)	Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:17573534^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P56817	F		Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	PMID:17573534^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12023	P		Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:20445063^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12023,UniProtKB:P49769	P	happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:20445063^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12023,UniProtKB:P49769	P	part_of:(GO:0090647) happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:1990535	neuron projection maintenance	PMID:20445063^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12023,UniProtKB:P49769	P	occurs_in:(CL:0000850) occurs_in:(GO:0030424)	Seeded From UniProt	complete
involved_in	GO:0035584	calcium-mediated signaling using intracellular calcium source	PMID:24012003^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	part_of:(GO:1904646) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	PMID:24012003^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	occurs_in:(CL:0000540) regulates:(GO:0035584)	Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	PMID:24012003^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q3UVX5	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
NOT\|involved_in	GO:0042982	amyloid precursor protein metabolic process	PMID:20445063^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12023,UniProtKB:P49769	P		Seeded From UniProt	complete
involved_in	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	PMID:22820466^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P39688	P	occurs_in:(CL:0002609) part_of:(GO:1904645) has_regulation_target:(UniProtKB:Q01097)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:19242475^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ComplexPortal:CPX-1139) part_of:(GO:1900272)	Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:23386614^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	has_regulation_target:(UniProtKB:P06241) has_agent:(GO:0045121)	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:19242475^[7]	ECO:0000353	physical interaction evidence used in manual assertion	ComplexPortal:CPX-1139	F	has_direct_input:(UniProtKB:P12023:PRO_0000000118) part_of:(GO:1900272)	Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	PMID:23386614^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(ComplexPortal:CPX-1134) has_agent:(GO:0045121)	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:22820466^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002609) part_of:(GO:1904645) has_regulation_target:(UniProtKB:P39688)	Seeded From UniProt	complete
involved_in	GO:1904645	response to amyloid-beta	PMID:22820466^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P39688	P	occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	PMID:20145049^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050860	negative regulation of T cell receptor signaling pathway	PMID:20145049^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046007	negative regulation of activated T cell proliferation	PMID:20145049^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:20145049^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032703	negative regulation of interleukin-2 production	PMID:20145049^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032700	negative regulation of interleukin-17 production	PMID:20145049^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032689	negative regulation of interferon-gamma production	PMID:20145049^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	PMID:20145049^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:9837873^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	PMID:23386614^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:19242475^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(UBERON:0002421) regulates:(GO:0060291)	Seeded From UniProt	complete
colocalizes_with	GO:0030425	dendrite	PMID:19242475^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 UniProtKB:P04156	P		Seeded From UniProt	complete
enables	GO:1903136	cuprous ion binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:1903135	cupric ion binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	F		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 RGD:3410	P		Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 UniProtKB:P04156	P		Seeded From UniProt	complete
involved_in	GO:1900449	regulation of glutamate receptor signaling pathway	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 UniProtKB:P04156	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 UniProtKB:P04156	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 RGD:3410	F		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 UniProtKB:P04156 UniProtKB:P27177	P		Seeded From UniProt	complete
involved_in	GO:0046686	response to cadmium ion	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 RGD:3410	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 RGD:3410	F		Seeded From UniProt	complete
involved_in	GO:0043086	negative regulation of catalytic activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 RGD:3410	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 RGD:3410	P		Seeded From UniProt	complete
enables	GO:0043008	ATP-dependent protein binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 RGD:3410	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	F		Seeded From UniProt	complete
involved_in	GO:0035584	calcium-mediated signaling using intracellular calcium source	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 UniProtKB:P04156	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	P		Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 RGD:3410 UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 UniProtKB:P04156	F		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 RGD:3410	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN002574842 RGD:3410 UniProtKB:P04156 UniProtKB:P09525	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574842 UniProtKB:P04156 UniProtKB:P13214	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN002574842 RGD:3410 UniProtKB:P04156 UniProtKB:P09525 UniProtKB:P13214	C		Seeded From UniProt	complete
enables	GO:0005539	glycosaminoglycan binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	F		Seeded From UniProt	complete
enables	GO:0005521	lamin binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 RGD:3410	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 UniProtKB:P04156	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904646	cellular response to amyloid-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	P		Seeded From UniProt	complete
enables	GO:1903136	cuprous ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903078	positive regulation of protein localization to plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902938	regulation of intracellular calcium activated chloride channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901379	regulation of potassium ion transmembrane transport	PMID:24225951^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:94921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900272	negative regulation of long-term synaptic potentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071280	cellular response to copper ion	PMID:16254249^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046688	response to copper ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046686	response to cadmium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:12927782^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:10037495^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:16254249^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043086	negative regulation of catalytic activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:15753097^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	P		Seeded From UniProt	complete
enables	GO:0043008	ATP-dependent protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035690	cellular response to drug	PMID:16254249^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035584	calcium-mediated signaling using intracellular calcium source	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032880	regulation of protein localization	PMID:10037495^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	C		Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031648	protein destabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	P		Seeded From UniProt	complete
colocalizes_with	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	C		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:24225951^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	C		Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:16254249^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	PMID:12500977^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16254249^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:11756421^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:11756421^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	C		Seeded From UniProt	complete
enables	GO:0005521	lamin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3410	F		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:12500977^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23892077^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04925	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22449963^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04925	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21441913^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04925	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21041683^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04925	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20345906^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04925	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19805070^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04925	F		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	P		Seeded From UniProt	complete
enables	GO:1903136	cuprous ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	F		Seeded From UniProt	complete
involved_in	GO:1902938	regulation of intracellular calcium activated chloride channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	P		Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	F		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	F		Seeded From UniProt	complete
involved_in	GO:0035584	calcium-mediated signaling using intracellular calcium source	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	C		Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	F		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	C		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	C		Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	C		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04156 ensembl:ENSP00000368752	F		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	P		Seeded From UniProt	complete
involved_in	GO:1900272	negative regulation of long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	F		Seeded From UniProt	complete
involved_in	GO:0046688	response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0046686	response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	F		Seeded From UniProt	complete
involved_in	GO:0043086	negative regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	P		Seeded From UniProt	complete
enables	GO:0043008	ATP-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	F		Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	C		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	C		Seeded From UniProt	complete
enables	GO:0005521	lamin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q53YK7 ensembl:ENSP00000368752	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q53YK7 ensembl:ENSP00000368752	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q53YK7 ensembl:ENSP00000368752	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000817 InterPro:IPR022416 InterPro:IPR036924	C		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000817 InterPro:IPR022416 InterPro:IPR036924	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:22820466^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-420384	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:12091459^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006878	cellular copper ion homeostasis	PMID:11756421^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006139	nucleobase-containing compound metabolic process	PMID:12206674^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0031225	anchored component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0336	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Barmada, S et al. (2004) GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice. Neurobiol. Dis. 16 527-37 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Parkin, ET et al. (2007) Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc. Natl. Acad. Sci. U.S.A. 104 11062-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Um, JW et al. (2013) Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Neuron 79 887-902 PubMed GONUTS page
↑ Stevens, DJ et al. (2009) Early onset prion disease from octarepeat expansion correlates with copper binding properties. PLoS Pathog. 5 e1000390 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Um, JW et al. (2012) Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat. Neurosci. 15 1227-35 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Gimbel, DA et al. (2010) Memory impairment in transgenic Alzheimer mice requires cellular prion protein. J. Neurosci. 30 6367-74 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Laurén, J et al. (2009) Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 457 1128-32 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Rushworth, JV et al. (2013) Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1. J. Biol. Chem. 288 8935-51 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Hu, W et al. (2010) Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling. Brain 133 375-88 PubMed GONUTS page
↑ Pauly, PC & Harris, DA (1998) Copper stimulates endocytosis of the prion protein. J. Biol. Chem. 273 33107-10 PubMed GONUTS page
↑ ^11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 ^11.14 ^11.15 ^11.16 ^11.17 ^11.18 ^11.19 ^11.20 ^11.21 ^11.22 ^11.23 ^11.24 ^11.25 ^11.26 ^11.27 ^11.28 ^11.29 ^11.30 ^11.31 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^12.0 ^12.1 Mercer, RC et al. (2013) The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. J. Biol. Chem. 288 37241-55 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Taylor, DR et al. (2005) Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis. J. Cell. Sci. 118 5141-53 PubMed GONUTS page
↑ Rouvinski, A et al. (2003) Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes. Biochem. Biophys. Res. Commun. 308 750-8 PubMed GONUTS page
↑ ^15.0 ^15.1 Keshet, GI et al. (1999) Scrapie-infected mice and PrP knockout mice share abnormal localization and activity of neuronal nitric oxide synthase. J. Neurochem. 72 1224-31 PubMed GONUTS page
↑ Li, A & Harris, DA (2005) Mammalian prion protein suppresses Bax-induced cell death in yeast. J. Biol. Chem. 280 17430-4 PubMed GONUTS page
↑ ^17.0 ^17.1 Rachidi, W et al. (2003) Expression of prion protein increases cellular copper binding and antioxidant enzyme activities but not copper delivery. J. Biol. Chem. 278 9064-72 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Lorenz, H et al. (2002) Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases. J. Biol. Chem. 277 8508-16 PubMed GONUTS page
↑ Dutta, A et al. (2013) The effect of β2-α2 loop mutation on amyloidogenic properties of the prion protein. FEBS Lett. 587 2918-23 PubMed GONUTS page
↑ Luo, JC et al. (2012) Formation of amyloid fibrils from β-amylase. FEBS Lett. 586 680-5 PubMed GONUTS page
↑ Smirnovas, V et al. (2011) Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange. Nat. Struct. Mol. Biol. 18 504-6 PubMed GONUTS page
↑ Khan, MQ et al. (2010) Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP. Proc. Natl. Acad. Sci. U.S.A. 107 19808-13 PubMed GONUTS page
↑ Gaspersic, J et al. (2010) Tetracysteine-tagged prion protein allows discrimination between the native and converted forms. FEBS J. 277 2038-50 PubMed GONUTS page
↑ Wille, H et al. (2009) Natural and synthetic prion structure from X-ray fiber diffraction. Proc. Natl. Acad. Sci. U.S.A. 106 16990-5 PubMed GONUTS page
↑ Shaked, Y et al. (2002) The binding of prion proteins to serum components is affected by detergent extraction conditions. J. Neurochem. 82 1-5 PubMed GONUTS page
↑ Nandi, PK et al. (2002) Unusual property of prion protein unfolding in neutral salt solution. Biochemistry 41 11017-24 PubMed GONUTS page

[PMID:15262264-1] Barmada, S et al. (2004) GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice. Neurobiol. Dis. 16 527-37 PubMed GONUTS page

[PMID:17573534-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Parkin, ET et al. (2007) Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc. Natl. Acad. Sci. U.S.A. 104 11062-7 PubMed GONUTS page

[PMID:24012003-3] 3.0 ^3.1 ^3.2 ^3.3 Um, JW et al. (2013) Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Neuron 79 887-902 PubMed GONUTS page

[PMID:19381258-4] Stevens, DJ et al. (2009) Early onset prion disease from octarepeat expansion correlates with copper binding properties. PLoS Pathog. 5 e1000390 PubMed GONUTS page

[PMID:22820466-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Um, JW et al. (2012) Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat. Neurosci. 15 1227-35 PubMed GONUTS page

[PMID:20445063-6] 6.0 ^6.1 ^6.2 ^6.3 Gimbel, DA et al. (2010) Memory impairment in transgenic Alzheimer mice requires cellular prion protein. J. Neurosci. 30 6367-74 PubMed GONUTS page

[PMID:19242475-7] 7.0 ^7.1 ^7.2 ^7.3 Laurén, J et al. (2009) Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 457 1128-32 PubMed GONUTS page

[PMID:23386614-8] 8.0 ^8.1 ^8.2 Rushworth, JV et al. (2013) Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1. J. Biol. Chem. 288 8935-51 PubMed GONUTS page

[PMID:20145049-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Hu, W et al. (2010) Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling. Brain 133 375-88 PubMed GONUTS page

[PMID:9837873-10] Pauly, PC & Harris, DA (1998) Copper stimulates endocytosis of the prion protein. J. Biol. Chem. 273 33107-10 PubMed GONUTS page

[PMID:21873635-11] 11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 ^11.14 ^11.15 ^11.16 ^11.17 ^11.18 ^11.19 ^11.20 ^11.21 ^11.22 ^11.23 ^11.24 ^11.25 ^11.26 ^11.27 ^11.28 ^11.29 ^11.30 ^11.31 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24225951-12] 12.0 ^12.1 Mercer, RC et al. (2013) The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6. J. Biol. Chem. 288 37241-55 PubMed GONUTS page

[PMID:16254249-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Taylor, DR et al. (2005) Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis. J. Cell. Sci. 118 5141-53 PubMed GONUTS page

[PMID:12927782-14] Rouvinski, A et al. (2003) Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes. Biochem. Biophys. Res. Commun. 308 750-8 PubMed GONUTS page

[PMID:10037495-15] 15.0 ^15.1 Keshet, GI et al. (1999) Scrapie-infected mice and PrP knockout mice share abnormal localization and activity of neuronal nitric oxide synthase. J. Neurochem. 72 1224-31 PubMed GONUTS page

[PMID:15753097-16] Li, A & Harris, DA (2005) Mammalian prion protein suppresses Bax-induced cell death in yeast. J. Biol. Chem. 280 17430-4 PubMed GONUTS page

[PMID:12500977-17] 17.0 ^17.1 Rachidi, W et al. (2003) Expression of prion protein increases cellular copper binding and antioxidant enzyme activities but not copper delivery. J. Biol. Chem. 278 9064-72 PubMed GONUTS page

[PMID:11756421-18] 18.0 ^18.1 ^18.2 Lorenz, H et al. (2002) Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases. J. Biol. Chem. 277 8508-16 PubMed GONUTS page

[PMID:23892077-19] Dutta, A et al. (2013) The effect of β2-α2 loop mutation on amyloidogenic properties of the prion protein. FEBS Lett. 587 2918-23 PubMed GONUTS page

[PMID:22449963-20] Luo, JC et al. (2012) Formation of amyloid fibrils from β-amylase. FEBS Lett. 586 680-5 PubMed GONUTS page

[PMID:21441913-21] Smirnovas, V et al. (2011) Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange. Nat. Struct. Mol. Biol. 18 504-6 PubMed GONUTS page

[PMID:21041683-22] Khan, MQ et al. (2010) Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP. Proc. Natl. Acad. Sci. U.S.A. 107 19808-13 PubMed GONUTS page

[PMID:20345906-23] Gaspersic, J et al. (2010) Tetracysteine-tagged prion protein allows discrimination between the native and converted forms. FEBS J. 277 2038-50 PubMed GONUTS page

[PMID:19805070-24] Wille, H et al. (2009) Natural and synthetic prion structure from X-ray fiber diffraction. Proc. Natl. Acad. Sci. U.S.A. 106 16990-5 PubMed GONUTS page

[PMID:12091459-25] Shaked, Y et al. (2002) The binding of prion proteins to serum components is affected by detergent extraction conditions. J. Neurochem. 82 1-5 PubMed GONUTS page

[PMID:12206674-26] Nandi, PK et al. (2002) Unusual property of prion protein unfolding in neutral salt solution. Biochemistry 41 11017-24 PubMed GONUTS page

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