MOUSE:PRDX2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Prdx2 (synonyms: Tdpx1, Tpx)
Protein Name(s)	Peroxiredoxin-2 Thiol-specific antioxidant protein TSA Thioredoxin peroxidase 1 Thioredoxin-dependent peroxide reductase 1
External Links
UniProt	Q61171
EMBL	U51679 X82067 U20611 AF032722 AF032718 AF032719 AF032720 AF032721 AK005225 AK008433 AK010653 AK088280 BC002034 BC081454
CCDS	CCDS40416.1
RefSeq	NP_035693.3 XP_006530898.1
UniGene	Mm.347009 Mm.393373
ProteinModelPortal	Q61171
SMR	Q61171
BioGrid	204094
IntAct	Q61171
MINT	MINT-1862390
PeroxiBase	4474
PhosphoSite	Q61171
REPRODUCTION-2DPAGE	Q61171
SWISS-2DPAGE	Q61171
UCD-2DPAGE	Q61171
MaxQB	Q61171
PaxDb	Q61171
PRIDE	Q61171
Ensembl	ENSMUST00000005292 ENSMUST00000109733 ENSMUST00000109734 ENSMUST00000164807
GeneID	21672
KEGG	mmu:21672
UCSC	uc009mom.1
CTD	7001
MGI	MGI:109486
eggNOG	COG0450
GeneTree	ENSGT00390000004653
HOGENOM	HOG000022343
HOVERGEN	HBG000286
InParanoid	Q61171
KO	K03386
OMA	MAACCSS
OrthoDB	EOG7T1RCD
PhylomeDB	Q61171
TreeFam	TF105181
Reactome	REACT_189141
ChiTaRS	Prdx2
NextBio	300952
PRO	PR:Q61171
Proteomes	UP000000589
Bgee	Q61171
CleanEx	MM_PRDX2
ExpressionAtlas	Q61171
Genevestigator	Q61171
GO	GO:0005739 GO:0004601 GO:0008430 GO:0008379 GO:0000187 GO:0048872 GO:0042744 GO:0042743 GO:2001237 GO:2001240 GO:0031665 GO:0032088 GO:2000378 GO:0045581 GO:0030194 GO:0010310 GO:0019430 GO:0002536 GO:0032496 GO:0006979 GO:0042098 GO:0048538
Gene3D	3.40.30.10
InterPro	IPR000866 IPR024706 IPR019479 IPR012336
Pfam	PF10417 PF00578
PIRSF	PIRSF000239
SUPFAM	SSF52833
PROSITE	PS51352

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006979	response to oxidative stress	PMID:20978343^[1]	ECO:0000315			P		Figure 7B. Prdx2 overexpression significantly decreased FeCl3-induced superoxide anion generation when compared with WT VSMCs.	complete
	GO:0010671	negative regulation of oxygen and reactive oxygen species metabolic process	PMID:20978343^[1]	ECO:0000315			P		FeCl3 treatment induced more ROS generation in the vessel walls of prdx2–/– mice than in prdx2 WT mice (Figure 7C).	complete
	GO:0016209	antioxidant activity	PMID:20978343^[1]	ECO:0000315			F		Prdx2 overexpression significantly decreased FeCl3-induced superoxide anion generation when compared with WT VSMCs (Figure 7B).	complete
part_of	GO:0043209	myelin sheath	PMID:17634366^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
involved_in	GO:0030194	positive regulation of blood coagulation	PMID:20978343^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019430	removal of superoxide radicals	PMID:20978343^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0040309 MGI:MGI:1859815 PANTHER:PTN000073874 PomBase:SPCC576.03c SGD:S000002861 SGD:S000004490 UniProtKB:P9WQB7	P		Seeded From UniProt	complete
involved_in	GO:0045321	leukocyte activation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109486 PANTHER:PTN001641775 UniProtKB:Q06830 ZFIN:ZDB-GENE-050320-35	P		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000189947 FB:FBgn0040308 FB:FBgn0040309 MGI:MGI:109486 PANTHER:PTN000073874 PomBase:SPCC576.03c UniProtKB:Q06830 UniProtKB:Q6ER94	P		Seeded From UniProt	complete
involved_in	GO:0019430	removal of superoxide radicals	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109486 PANTHER:PTN002580968 UniProtKB:P32119	P		Seeded From UniProt	complete
enables	GO:0008379	thioredoxin peroxidase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000189947 FB:FBgn0040308 FB:FBgn0040309 PANTHER:PTN000073874 PomBase:SPCC576.03c SGD:S000002861 SGD:S000004490 UniProtKB:P32119 UniProtKB:Q06830 UniProtKB:Q8I5Q6 UniProtKB:Q8IL80	F		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0040308 FB:FBgn0040309 MGI:MGI:99523 PANTHER:PTN000073874 RGD:3838 RGD:620039 UniProtKB:P32119 UniProtKB:Q8I5Q6 UniProtKB:Q8IL80	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11384 FB:FBgn0040308 FB:FBgn0040309 MGI:MGI:1859815 PANTHER:PTN000073874 RGD:3838 RGD:620039 SGD:S000004490 UniProtKB:Q8IL80	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	PMID:9115640^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:15259009^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668456	P	regulates_o_occurs_in:(EMAPA:18768) regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048872	homeostasis of number of cells	PMID:15259009^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668456	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048538	thymus development	PMID:15259009^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668456	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045581	negative regulation of T cell differentiation	PMID:16290204^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668456	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3838	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042744	hydrogen peroxide catabolic process	PMID:15902258^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668456	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042743	hydrogen peroxide metabolic process	PMID:17325201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668456	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042743	hydrogen peroxide metabolic process	PMID:15259009^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668456	P	occurs_in:(EMAPA:18768) occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042098	T cell proliferation	PMID:15259009^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668456	P	occurs_in:(EMAPA:18768) acts_on_population_of:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034599	cellular response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:17325201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668456	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:17325201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668456	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	PMID:17325201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668456	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019430	removal of superoxide radicals	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32119	P		Seeded From UniProt	complete
enables	GO:0016209	antioxidant activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32119	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010310	regulation of hydrogen peroxide metabolic process	PMID:17325201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668456	P		Seeded From UniProt	complete
enables	GO:0008379	thioredoxin peroxidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32119	F		Seeded From UniProt	complete
enables	GO:0008379	thioredoxin peroxidase activity	PMID:9115640^[4]	ECO:0000250	sequence similarity evidence used in manual assertion		F		Seeded From UniProt	Missing: with/from
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3838	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3838	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002536	respiratory burst involved in inflammatory response	PMID:17325201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668456	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000187	activation of MAPK activity	PMID:17325201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2668456	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32119 ensembl:ENSP00000301522	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32119 ensembl:ENSP00000301522	P		Seeded From UniProt	complete
involved_in	GO:0019430	removal of superoxide radicals	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32119 ensembl:ENSP00000301522	P		Seeded From UniProt	complete
enables	GO:0016209	antioxidant activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32119 ensembl:ENSP00000301522	F		Seeded From UniProt	complete
enables	GO:0008379	thioredoxin peroxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32119 ensembl:ENSP00000301522	F		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P32119 ensembl:ENSP00000301522	P		Seeded From UniProt	complete
enables	GO:0016209	antioxidant activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000866	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000866	F		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013766	P		Seeded From UniProt	complete
enables	GO:0051920	peroxiredoxin activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019479	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000866 InterPro:IPR019479	P		Seeded From UniProt	complete
enables	GO:0051920	peroxiredoxin activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.11.1.15	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-8868589	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008430	selenium binding	PMID:9792801^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008379	thioredoxin peroxidase activity	PMID:9714804^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	PMID:9115640^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	PMID:9115640^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
enables	GO:0016209	antioxidant activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0049	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0575	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Li, W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J. Clin. Invest. 120 3996-4006 PubMed GONUTS page
↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Ichimiya, S et al. (1997) Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury. DNA Cell Biol. 16 311-21 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Moon, EY et al. (2004) Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus. Eur. J. Immunol. 34 2119-28 PubMed GONUTS page
↑ Moon, EY et al. (2006) T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene. Immunol. Lett. 102 184-90 PubMed GONUTS page
↑ Choi, MH et al. (2005) Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature 435 347-53 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Yang, CS et al. (2007) Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. J. Exp. Med. 204 583-94 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Gladyshev, VN et al. (1998) Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells. Biochem. Biophys. Res. Commun. 251 488-93 PubMed GONUTS page
↑ Lim, MJ et al. (1998) The type II peroxiredoxin gene family of the mouse: molecular structure, expression and evolution. Gene 216 197-205 PubMed GONUTS page

[PMID:20978343-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Li, W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J. Clin. Invest. 120 3996-4006 PubMed GONUTS page

[PMID:17634366-2] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9115640-4] 4.0 ^4.1 ^4.2 ^4.3 Ichimiya, S et al. (1997) Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury. DNA Cell Biol. 16 311-21 PubMed GONUTS page

[PMID:15259009-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Moon, EY et al. (2004) Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus. Eur. J. Immunol. 34 2119-28 PubMed GONUTS page

[PMID:16290204-6] Moon, EY et al. (2006) T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene. Immunol. Lett. 102 184-90 PubMed GONUTS page

[PMID:15902258-7] Choi, MH et al. (2005) Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature 435 347-53 PubMed GONUTS page

[PMID:17325201-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Yang, CS et al. (2007) Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. J. Exp. Med. 204 583-94 PubMed GONUTS page

[PMID:18614015-9] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:9792801-10] Gladyshev, VN et al. (1998) Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells. Biochem. Biophys. Res. Commun. 251 488-93 PubMed GONUTS page

[PMID:9714804-11] Lim, MJ et al. (1998) The type II peroxiredoxin gene family of the mouse: molecular structure, expression and evolution. Gene 216 197-205 PubMed GONUTS page

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MOUSE:PRDX2

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