GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:PRDX2
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Prdx2 (synonyms: Tdpx1, Tpx) | |
Protein Name(s) | Peroxiredoxin-2
Thiol-specific antioxidant protein TSA Thioredoxin peroxidase 1 Thioredoxin-dependent peroxide reductase 1 | |
External Links | ||
UniProt | Q61171 | |
EMBL | U51679 X82067 U20611 AF032722 AF032718 AF032719 AF032720 AF032721 AK005225 AK008433 AK010653 AK088280 BC002034 BC081454 | |
CCDS | CCDS40416.1 | |
RefSeq | NP_035693.3 XP_006530898.1 | |
UniGene | Mm.347009 Mm.393373 | |
ProteinModelPortal | Q61171 | |
SMR | Q61171 | |
BioGrid | 204094 | |
IntAct | Q61171 | |
MINT | MINT-1862390 | |
PeroxiBase | 4474 | |
PhosphoSite | Q61171 | |
REPRODUCTION-2DPAGE | Q61171 | |
SWISS-2DPAGE | Q61171 | |
UCD-2DPAGE | Q61171 | |
MaxQB | Q61171 | |
PaxDb | Q61171 | |
PRIDE | Q61171 | |
Ensembl | ENSMUST00000005292 ENSMUST00000109733 ENSMUST00000109734 ENSMUST00000164807 | |
GeneID | 21672 | |
KEGG | mmu:21672 | |
UCSC | uc009mom.1 | |
CTD | 7001 | |
MGI | MGI:109486 | |
eggNOG | COG0450 | |
GeneTree | ENSGT00390000004653 | |
HOGENOM | HOG000022343 | |
HOVERGEN | HBG000286 | |
InParanoid | Q61171 | |
KO | K03386 | |
OMA | MAACCSS | |
OrthoDB | EOG7T1RCD | |
PhylomeDB | Q61171 | |
TreeFam | TF105181 | |
Reactome | REACT_189141 | |
ChiTaRS | Prdx2 | |
NextBio | 300952 | |
PRO | PR:Q61171 | |
Proteomes | UP000000589 | |
Bgee | Q61171 | |
CleanEx | MM_PRDX2 | |
ExpressionAtlas | Q61171 | |
Genevestigator | Q61171 | |
GO | GO:0005739 GO:0004601 GO:0008430 GO:0008379 GO:0000187 GO:0048872 GO:0042744 GO:0042743 GO:2001237 GO:2001240 GO:0031665 GO:0032088 GO:2000378 GO:0045581 GO:0030194 GO:0010310 GO:0019430 GO:0002536 GO:0032496 GO:0006979 GO:0042098 GO:0048538 | |
Gene3D | 3.40.30.10 | |
InterPro | IPR000866 IPR024706 IPR019479 IPR012336 | |
Pfam | PF10417 PF00578 | |
PIRSF | PIRSF000239 | |
SUPFAM | SSF52833 | |
PROSITE | PS51352 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0006979 |
response to oxidative stress |
ECO:0000315 |
P |
Figure 7B. Prdx2 overexpression significantly decreased FeCl3-induced superoxide anion generation when compared with WT VSMCs. |
complete | |||||
GO:0010671 |
negative regulation of oxygen and reactive oxygen species metabolic process |
ECO:0000315 |
P |
FeCl3 treatment induced more ROS generation in the vessel walls of prdx2–/– mice than in prdx2 WT mice (Figure 7C). |
complete | |||||
GO:0016209 |
antioxidant activity |
ECO:0000315 |
F |
Prdx2 overexpression significantly decreased FeCl3-induced superoxide anion generation when compared with WT VSMCs (Figure 7B). |
complete | |||||
part_of |
GO:0043209 |
myelin sheath |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000128) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030194 |
positive regulation of blood coagulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019430 |
removal of superoxide radicals |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045454 |
cell redox homeostasis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0040309 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045321 |
leukocyte activation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109486 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042744 |
hydrogen peroxide catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
CGD:CAL0000189947 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019430 |
removal of superoxide radicals |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109486 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008379 |
thioredoxin peroxidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
CGD:CAL0000189947 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006979 |
response to oxidative stress |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0040308 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG11384 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:2001240 |
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:2001237 |
negative regulation of extrinsic apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668456 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0048872 |
homeostasis of number of cells |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668456 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048538 |
thymus development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668456 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045581 |
negative regulation of T cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668456 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3838 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0042981 |
regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0042744 |
hydrogen peroxide catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668456 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0042743 |
hydrogen peroxide metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668456 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0042743 |
hydrogen peroxide metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668456 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0042098 |
T cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668456 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668456 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668456 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0031665 |
negative regulation of lipopolysaccharide-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668456 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0019430 |
removal of superoxide radicals |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016209 |
antioxidant activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010310 |
regulation of hydrogen peroxide metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668456 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008379 |
thioredoxin peroxidase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008379 |
thioredoxin peroxidase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
acts_upstream_of_or_within |
GO:0006979 |
response to oxidative stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006979 |
response to oxidative stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3838 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3838 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0002536 |
respiratory burst involved in inflammatory response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668456 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0000187 |
activation of MAPK activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668456 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P32119 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034599 |
cellular response to oxidative stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P32119 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019430 |
removal of superoxide radicals |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P32119 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0016209 |
antioxidant activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P32119 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008379 |
thioredoxin peroxidase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P32119 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006979 |
response to oxidative stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P32119 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0016209 |
antioxidant activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045454 |
cell redox homeostasis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051920 |
peroxiredoxin activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051920 |
peroxiredoxin activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
Reactome:R-MMU-8868589 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0008430 |
selenium binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008379 |
thioredoxin peroxidase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006979 |
response to oxidative stress |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004601 |
peroxidase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016209 |
antioxidant activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004601 |
peroxidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Li, W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J. Clin. Invest. 120 3996-4006 PubMed GONUTS page
- ↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Ichimiya, S et al. (1997) Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury. DNA Cell Biol. 16 311-21 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Moon, EY et al. (2004) Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus. Eur. J. Immunol. 34 2119-28 PubMed GONUTS page
- ↑ Moon, EY et al. (2006) T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene. Immunol. Lett. 102 184-90 PubMed GONUTS page
- ↑ Choi, MH et al. (2005) Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature 435 347-53 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 Yang, CS et al. (2007) Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. J. Exp. Med. 204 583-94 PubMed GONUTS page
- ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
- ↑ Gladyshev, VN et al. (1998) Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells. Biochem. Biophys. Res. Commun. 251 488-93 PubMed GONUTS page
- ↑ Lim, MJ et al. (1998) The type II peroxiredoxin gene family of the mouse: molecular structure, expression and evolution. Gene 216 197-205 PubMed GONUTS page
c
g
h
m
n
- GO:0043524 ! negative regulation of neuron apoptotic process
- GO:0031665 ! negative regulation of lipopolysaccharide-mediated signaling pathway
- GO:0032088 ! negative regulation of NF-kappaB transcription factor activity
- GO:2001240 ! negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway
- GO:0045581 ! negative regulation of T cell differentiation
o
p
r
- GO:0010310 ! regulation of hydrogen peroxide metabolic process
- GO:0042981 ! regulation of apoptotic process
- GO:0019430 ! removal of superoxide radicals
- GO:0002536 ! respiratory burst involved in inflammatory response
- GO:0032496 ! response to lipopolysaccharide
- GO:0006979 ! response to oxidative stress
- Rodentia
t