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MOUSE:PRDX2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Prdx2 (synonyms: Tdpx1, Tpx)
Protein Name(s) Peroxiredoxin-2

Thiol-specific antioxidant protein TSA Thioredoxin peroxidase 1 Thioredoxin-dependent peroxide reductase 1

External Links
UniProt Q61171
EMBL U51679
X82067
U20611
AF032722
AF032718
AF032719
AF032720
AF032721
AK005225
AK008433
AK010653
AK088280
BC002034
BC081454
CCDS CCDS40416.1
RefSeq NP_035693.3
XP_006530898.1
UniGene Mm.347009
Mm.393373
ProteinModelPortal Q61171
SMR Q61171
BioGrid 204094
IntAct Q61171
MINT MINT-1862390
PeroxiBase 4474
PhosphoSite Q61171
REPRODUCTION-2DPAGE Q61171
SWISS-2DPAGE Q61171
UCD-2DPAGE Q61171
MaxQB Q61171
PaxDb Q61171
PRIDE Q61171
Ensembl ENSMUST00000005292
ENSMUST00000109733
ENSMUST00000109734
ENSMUST00000164807
GeneID 21672
KEGG mmu:21672
UCSC uc009mom.1
CTD 7001
MGI MGI:109486
eggNOG COG0450
GeneTree ENSGT00390000004653
HOGENOM HOG000022343
HOVERGEN HBG000286
InParanoid Q61171
KO K03386
OMA MAACCSS
OrthoDB EOG7T1RCD
PhylomeDB Q61171
TreeFam TF105181
Reactome REACT_189141
ChiTaRS Prdx2
NextBio 300952
PRO PR:Q61171
Proteomes UP000000589
Bgee Q61171
CleanEx MM_PRDX2
ExpressionAtlas Q61171
Genevestigator Q61171
GO GO:0005739
GO:0004601
GO:0008430
GO:0008379
GO:0000187
GO:0048872
GO:0042744
GO:0042743
GO:2001237
GO:2001240
GO:0031665
GO:0032088
GO:2000378
GO:0045581
GO:0030194
GO:0010310
GO:0019430
GO:0002536
GO:0032496
GO:0006979
GO:0042098
GO:0048538
Gene3D 3.40.30.10
InterPro IPR000866
IPR024706
IPR019479
IPR012336
Pfam PF10417
PF00578
PIRSF PIRSF000239
SUPFAM SSF52833
PROSITE PS51352

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006979

response to oxidative stress

PMID:20978343[1]

ECO:0000315

P

Figure 7B. Prdx2 overexpression significantly decreased FeCl3-induced superoxide anion generation when compared with WT VSMCs.

complete

GO:0010671

negative regulation of oxygen and reactive oxygen species metabolic process

PMID:20978343[1]

ECO:0000315

P

FeCl3 treatment induced more ROS generation in the vessel walls of prdx2–/– mice than in prdx2 WT mice (Figure 7C).

complete

GO:0016209

antioxidant activity

PMID:20978343[1]

ECO:0000315

F

Prdx2 overexpression significantly decreased FeCl3-induced superoxide anion generation when compared with WT VSMCs (Figure 7B).

complete

part_of

GO:0043209

myelin sheath

PMID:17634366[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000128)

Seeded From UniProt

complete

involved_in

GO:0030194

positive regulation of blood coagulation

PMID:20978343[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019430

removal of superoxide radicals

PMID:20978343[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040309
MGI:MGI:1859815
PANTHER:PTN000073874
PomBase:SPCC576.03c
SGD:S000002861
SGD:S000004490
UniProtKB:P9WQB7

P

Seeded From UniProt

complete

involved_in

GO:0045321

leukocyte activation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109486
PANTHER:PTN001641775
UniProtKB:Q06830
ZFIN:ZDB-GENE-050320-35

P

Seeded From UniProt

complete

involved_in

GO:0042744

hydrogen peroxide catabolic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000189947
FB:FBgn0040308
FB:FBgn0040309
MGI:MGI:109486
PANTHER:PTN000073874
PomBase:SPCC576.03c
UniProtKB:Q06830
UniProtKB:Q6ER94

P

Seeded From UniProt

complete

involved_in

GO:0019430

removal of superoxide radicals

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109486
PANTHER:PTN002580968
UniProtKB:P32119

P

Seeded From UniProt

complete

enables

GO:0008379

thioredoxin peroxidase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000189947
FB:FBgn0040308
FB:FBgn0040309
PANTHER:PTN000073874
PomBase:SPCC576.03c
SGD:S000002861
SGD:S000004490
UniProtKB:P32119
UniProtKB:Q06830
UniProtKB:Q8I5Q6
UniProtKB:Q8IL80

F

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0040308
FB:FBgn0040309
MGI:MGI:99523
PANTHER:PTN000073874
RGD:3838
RGD:620039
UniProtKB:P32119
UniProtKB:Q8I5Q6
UniProtKB:Q8IL80

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11384
FB:FBgn0040308
FB:FBgn0040309
MGI:MGI:1859815
PANTHER:PTN000073874
RGD:3838
RGD:620039
SGD:S000004490
UniProtKB:Q8IL80

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

PMID:9115640[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

PMID:15259009[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668456

P

  • regulates_o_occurs_in:(EMAPA:18768)
  • regulates_o_occurs_in:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048872

homeostasis of number of cells

PMID:15259009[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668456

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048538

thymus development

PMID:15259009[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668456

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045581

negative regulation of T cell differentiation

PMID:16290204[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668456

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3838

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042981

regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P32119

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042744

hydrogen peroxide catabolic process

PMID:15902258[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668456

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042743

hydrogen peroxide metabolic process

PMID:17325201[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668456

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042743

hydrogen peroxide metabolic process

PMID:15259009[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668456

P

  • occurs_in:(EMAPA:18768)
  • occurs_in:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042098

T cell proliferation

PMID:15259009[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668456

P

  • occurs_in:(EMAPA:18768)
  • acts_on_population_of:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034599

cellular response to oxidative stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P32119

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032496

response to lipopolysaccharide

PMID:17325201[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668456

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032088

negative regulation of NF-kappaB transcription factor activity

PMID:17325201[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668456

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031665

negative regulation of lipopolysaccharide-mediated signaling pathway

PMID:17325201[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668456

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019430

removal of superoxide radicals

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P32119

P

Seeded From UniProt

complete

enables

GO:0016209

antioxidant activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P32119

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010310

regulation of hydrogen peroxide metabolic process

PMID:17325201[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668456

P

Seeded From UniProt

complete

enables

GO:0008379

thioredoxin peroxidase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P32119

F

Seeded From UniProt

complete

enables

GO:0008379

thioredoxin peroxidase activity

PMID:9115640[4]

ECO:0000250

sequence similarity evidence used in manual assertion

F

Seeded From UniProt

Missing: with/from

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P32119

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3838

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3838

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:18614015[9]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002536

respiratory burst involved in inflammatory response

PMID:17325201[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668456

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000187

activation of MAPK activity

PMID:17325201[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668456

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32119
ensembl:ENSP00000301522

P

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32119
ensembl:ENSP00000301522

P

Seeded From UniProt

complete

involved_in

GO:0019430

removal of superoxide radicals

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32119
ensembl:ENSP00000301522

P

Seeded From UniProt

complete

enables

GO:0016209

antioxidant activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32119
ensembl:ENSP00000301522

F

Seeded From UniProt

complete

enables

GO:0008379

thioredoxin peroxidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32119
ensembl:ENSP00000301522

F

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P32119
ensembl:ENSP00000301522

P

Seeded From UniProt

complete

enables

GO:0016209

antioxidant activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000866

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000866

F

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013766

P

Seeded From UniProt

complete

enables

GO:0051920

peroxiredoxin activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019479

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000866
InterPro:IPR019479

P

Seeded From UniProt

complete

enables

GO:0051920

peroxiredoxin activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.11.1.15

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-MMU-8868589

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008430

selenium binding

PMID:9792801[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008379

thioredoxin peroxidase activity

PMID:9714804[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

PMID:9115640[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004601

peroxidase activity

PMID:9115640[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0016209

antioxidant activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0049

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

enables

GO:0004601

peroxidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0575

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Li, W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J. Clin. Invest. 120 3996-4006 PubMed GONUTS page
  2. Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Ichimiya, S et al. (1997) Murine thioredoxin peroxidase delays neuronal apoptosis and is expressed in areas of the brain most susceptible to hypoxic and ischemic injury. DNA Cell Biol. 16 311-21 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 Moon, EY et al. (2004) Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus. Eur. J. Immunol. 34 2119-28 PubMed GONUTS page
  6. Moon, EY et al. (2006) T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene. Immunol. Lett. 102 184-90 PubMed GONUTS page
  7. Choi, MH et al. (2005) Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature 435 347-53 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 8.6 Yang, CS et al. (2007) Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock. J. Exp. Med. 204 583-94 PubMed GONUTS page
  9. Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
  10. Gladyshev, VN et al. (1998) Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells. Biochem. Biophys. Res. Commun. 251 488-93 PubMed GONUTS page
  11. Lim, MJ et al. (1998) The type II peroxiredoxin gene family of the mouse: molecular structure, expression and evolution. Gene 216 197-205 PubMed GONUTS page