MOUSE:PLM

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fxyd1 (synonyms: Plm)
Protein Name(s)	Phospholemman FXYD domain-containing ion transport regulator 1
External Links
UniProt	Q9Z239
EMBL	AF091390 AF089734 AK002585 BC024671
CCDS	CCDS21123.1
RefSeq	NP_062376.2 NP_443717.1 NP_443718.1 NP_919302.1 XP_006540283.1
UniGene	Mm.1491
ProteinModelPortal	Q9Z239
SMR	Q9Z239
STRING	10090.ENSMUSP00000048460
PhosphoSite	Q9Z239
PaxDb	Q9Z239
PRIDE	Q9Z239
Ensembl	ENSMUST00000039909 ENSMUST00000071697 ENSMUST00000108110
GeneID	56188
KEGG	mmu:56188
UCSC	uc009ghu.2
CTD	5348
MGI	MGI:1889273
eggNOG	NOG42110
GeneTree	ENSGT00530000063932
HOGENOM	HOG000234467
HOVERGEN	HBG008212
InParanoid	Q9Z239
KO	K13360
OMA	QEPDPFT
OrthoDB	EOG7WHHDM
PhylomeDB	Q9Z239
TreeFam	TF333443
Reactome	REACT_250224
ChiTaRS	Fxyd1
NextBio	311978
PRO	PR:Q9Z239
Proteomes	UP000000589
Bgee	Q9Z239
CleanEx	MM_FXYD1
Genevestigator	Q9Z239
GO	GO:0034707 GO:0042383 GO:0005890 GO:0005254 GO:0044325 GO:0017080 GO:0006874 GO:0006936 GO:1903278 GO:0086036 GO:2000649
InterPro	IPR000272
Pfam	PF02038
ProDom	PD005989
PROSITE	PS01310

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010734	negative regulation of protein glutathionylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56513	P		Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08589	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08589	C		Seeded From UniProt	complete
part_of	GO:0005890	sodium:potassium-exchanging ATPase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3SZX0	C		Seeded From UniProt	complete
involved_in	GO:1903278	positive regulation of sodium ion export across plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3SZX0	P		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P56513	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08589	C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O08589	C		Seeded From UniProt	complete
part_of	GO:0005890	sodium:potassium-exchanging ATPase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:I3LMB3	C	part_of:(UBERON:0000948) part_of:(GO:0042383)	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:I3LMB3	F	occurs_in:(UBERON:0000948) occurs_in:(GO:0042383)	Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:15563542^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:2000649	regulation of sodium ion transmembrane transporter activity	PMID:15563542^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:15563542^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0086036	regulation of cardiac muscle cell membrane potential	PMID:17095720^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:17095720^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0002131)	Seeded From UniProt	complete
involved_in	GO:1903278	positive regulation of sodium ion export across plasma membrane	PMID:17095720^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002131)	Seeded From UniProt	complete
involved_in	GO:2000649	regulation of sodium ion transmembrane transporter activity	PMID:17095720^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002131)	Seeded From UniProt	complete
involved_in	GO:2000649	regulation of sodium ion transmembrane transporter activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1195260 MGI:MGI:1889273 PANTHER:PTN000364858	P		Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1195260 MGI:MGI:1889273 PANTHER:PTN000364858 UniProtKB:P56513	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903797	positive regulation of inorganic anion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69306	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0086004	regulation of cardiac muscle cell contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69306	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051480	regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69306	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69306	F		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69306	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032892	positive regulation of organic acid transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69306	P		Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69306	C		Seeded From UniProt	complete
enables	GO:0017022	myosin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69306	F		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69306	C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69306	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69306	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69306	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000272	C		Seeded From UniProt	complete
involved_in	GO:0043269	regulation of ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000272	P		Seeded From UniProt	complete
enables	GO:0099106	ion channel regulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000272	F		Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0740 UniProtKB-KW:KW-0739	P		Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0740 UniProtKB-KW:KW-0633	P		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0238	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0035	C		Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0505	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0015	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Jia, LG et al. (2005) Hypertrophy, increased ejection fraction, and reduced Na-K-ATPase activity in phospholemman-deficient mice. Am. J. Physiol. Heart Circ. Physiol. 288 H1982-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Han, F et al. (2006) Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes. Circ. Res. 99 1376-83 PubMed GONUTS page
↑ ^3.0 ^3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15563542-1] 1.0 ^1.1 ^1.2 Jia, LG et al. (2005) Hypertrophy, increased ejection fraction, and reduced Na-K-ATPase activity in phospholemman-deficient mice. Am. J. Physiol. Heart Circ. Physiol. 288 H1982-8 PubMed GONUTS page

[PMID:17095720-2] 2.0 ^2.1 ^2.2 ^2.3 Han, F et al. (2006) Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes. Circ. Res. 99 1376-83 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:PLM

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