MOUSE:PLIN5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Plin5 (synonyms: Lsdp5, Mldp, Oxpat, Pat1)
Protein Name(s)	Perilipin-5 Lipid droplet-associated protein PAT-1 Lipid storage droplet protein 5 Myocardial LD protein
External Links
UniProt	Q8BVZ1
EMBL	DQ473305 AY919875 AK075872 BC024138
CCDS	CCDS37662.1
RefSeq	NP_001070816.1 NP_080150.2
UniGene	Mm.254985
ProteinModelPortal	Q8BVZ1
SMR	Q8BVZ1
BioGrid	211843
PhosphoSite	Q8BVZ1
MaxQB	Q8BVZ1
PaxDb	Q8BVZ1
PRIDE	Q8BVZ1
Ensembl	ENSMUST00000019808 ENSMUST00000113072
GeneID	66968
KEGG	mmu:66968
UCSC	uc008daz.1
CTD	440503
MGI	MGI:1914218
eggNOG	NOG68472
GeneTree	ENSGT00500000044795
HOGENOM	HOG000033816
HOVERGEN	HBG002935
InParanoid	Q8BVZ1
OMA	CRLAEHC
OrthoDB	EOG7SN8CD
PhylomeDB	Q8BVZ1
TreeFam	TF328397
NextBio	323159
PRO	PR:Q8BVZ1
Proteomes	UP000000589
Bgee	Q8BVZ1
Genevestigator	Q8BVZ1
GO	GO:0005737 GO:0005829 GO:0005811 GO:0005739 GO:0042802 GO:0035473 GO:0006629 GO:0034389 GO:0019915 GO:0051646 GO:0031999 GO:0060192 GO:0050995 GO:0035359 GO:2000378 GO:0010897 GO:0032000 GO:0060193 GO:0010884 GO:0010890 GO:0010867
InterPro	IPR004279
PANTHER	PTHR14024
Pfam	PF03036
PIRSF	PIRSF036881

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010890	positive regulation of sequestering of triglyceride	PMID:22675471^[1]	ECO:0000314			P		Figure #3 shows that "a higher concentration of TGs was observed in cells overexpressing LSDP5 compared with controls".	complete CACAO 5266
	GO:0010890	positive regulation of sequestering of triglyceride	PMID:3365886^[2]	ECO:0000314			P		Figure 3b says that "lipid droplets were stained using BODIPY (neutral lipid dye). BODIPY fluorescence increased in cells overexpressing LSDP5. The mRNA level of adipophilin, a protein that coats lipid droplets, was increased in cells overexpressing LSDP5 (Figure 3C). The amount of TGs in cells overexpressing LSDP5 also significantly increased, compared to control cells, which was determined using a TG test kit (P=0.014) (Figure 3D). The phenotypes of increased lipid droplet storage and increased TG contents were also observed in primary hepatocytes (Figure S1). These data demonstrate that the overexpression of LSDP5 is associated with an increased cellular TG content".	complete CACAO 5600
	GO:0019915	lipid storage	PMID:22675471^[1]	ECO:0000314			P		Figure 3 shows overexpression of Lspd5 causes increased lipid storage	complete CACAO 5665
	GO:0005811	lipid particle	PMID:22675471^[1]	ECO:0000314			C		Figure 1 shows Lsdp5 colocalized with lipid droplets.	complete CACAO 5666
part_of	GO:0005811	lipid droplet	PMID:22675471^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019915	lipid storage	PMID:22675471^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	PMID:22532565^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060193	positive regulation of lipase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:M0R7Z9	P		Seeded From UniProt	complete
involved_in	GO:0060192	negative regulation of lipase activity	PMID:22532565^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051646	mitochondrion localization	PMID:21885430^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	PMID:21885430^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21148142^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8BVZ1	F		Seeded From UniProt	complete
enables	GO:0035473	lipase binding	PMID:21148142^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8BJ56	F		Seeded From UniProt	complete
enables	GO:0035473	lipase binding	PMID:19717842^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P54310	F		Seeded From UniProt	complete
involved_in	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway	PMID:22675471^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034389	lipid droplet organization	PMID:22532565^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032000	positive regulation of fatty acid beta-oxidation	PMID:17130488^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031999	negative regulation of fatty acid beta-oxidation	PMID:22532565^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031999	negative regulation of fatty acid beta-oxidation	PMID:22675471^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031999	negative regulation of fatty acid beta-oxidation	PMID:21885430^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019915	lipid storage	PMID:21148142^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010897	negative regulation of triglyceride catabolic process	PMID:23345411^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010897	negative regulation of triglyceride catabolic process	PMID:22675471^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010890	positive regulation of sequestering of triglyceride	PMID:22675471^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010884	positive regulation of lipid storage	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:M0R7Z9	P		Seeded From UniProt	complete
involved_in	GO:0010867	positive regulation of triglyceride biosynthetic process	PMID:22532565^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010867	positive regulation of triglyceride biosynthetic process	PMID:21885430^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010867	positive regulation of triglyceride biosynthetic process	PMID:17130488^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	PMID:21148142^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005811	lipid droplet	PMID:17130488^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:M0R7Z9	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19717842^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060193	positive regulation of lipase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1589602	P		Seeded From UniProt	complete
enables	GO:0035473	lipase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1589602	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032000	positive regulation of fatty acid beta-oxidation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1589602	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010890	positive regulation of sequestering of triglyceride	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1589602	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010884	positive regulation of lipid storage	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1589602	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16571721^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	PMID:16571721^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105)\|part_of:(CL:0000178)	Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1589602	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1589602	C		Seeded From UniProt	complete
involved_in	GO:0060193	positive regulation of lipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:M0R7Z9 ensembl:ENSRNOP00000065588	P		Seeded From UniProt	complete
enables	GO:0035473	lipase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:M0R7Z9 ensembl:ENSRNOP00000065588	F		Seeded From UniProt	complete
involved_in	GO:0032000	positive regulation of fatty acid beta-oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:M0R7Z9 ensembl:ENSRNOP00000065588	P		Seeded From UniProt	complete
involved_in	GO:0010890	positive regulation of sequestering of triglyceride	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:M0R7Z9 ensembl:ENSRNOP00000065588	P		Seeded From UniProt	complete
involved_in	GO:0010884	positive regulation of lipid storage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:M0R7Z9 ensembl:ENSRNOP00000065588	P		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:M0R7Z9 ensembl:ENSRNOP00000065588	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:M0R7Z9 ensembl:ENSRNOP00000065588	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0005811	lipid droplet	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0551 UniProtKB-SubCell:SL-0154	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Li, H et al. (2012) LSDP5 enhances triglyceride storage in hepatocytes by influencing lipolysis and fatty acid β-oxidation of lipid droplets. PLoS ONE 7 e36712 PubMed GONUTS page
↑ Dodge, LD et al. (1988) Concurrent lumbar spinal stenosis and peripheral vascular disease. A report of nine patients. Clin. Orthop. Relat. Res. 141-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Kuramoto, K et al. (2012) Perilipin 5, a lipid droplet-binding protein, protects heart from oxidative burden by sequestering fatty acid from excessive oxidation. J. Biol. Chem. 287 23852-63 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Wang, H et al. (2011) Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria. J. Lipid Res. 52 2159-68 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Granneman, JG et al. (2011) Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase. J. Biol. Chem. 286 5126-35 PubMed GONUTS page
↑ ^6.0 ^6.1 Wang, H et al. (2009) Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins. J. Biol. Chem. 284 32116-25 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Wolins, NE et al. (2006) OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes 55 3418-28 PubMed GONUTS page
↑ Wang, H et al. (2013) Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction. J. Lipid Res. 54 953-65 PubMed GONUTS page
↑ ^9.0 ^9.1 Yamaguchi, T et al. (2006) MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 281 14232-40 PubMed GONUTS page

[PMID:22675471-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Li, H et al. (2012) LSDP5 enhances triglyceride storage in hepatocytes by influencing lipolysis and fatty acid β-oxidation of lipid droplets. PLoS ONE 7 e36712 PubMed GONUTS page

[PMID:3365886-2] Dodge, LD et al. (1988) Concurrent lumbar spinal stenosis and peripheral vascular disease. A report of nine patients. Clin. Orthop. Relat. Res. 141-8 PubMed GONUTS page

[PMID:22532565-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Kuramoto, K et al. (2012) Perilipin 5, a lipid droplet-binding protein, protects heart from oxidative burden by sequestering fatty acid from excessive oxidation. J. Biol. Chem. 287 23852-63 PubMed GONUTS page

[PMID:21885430-4] 4.0 ^4.1 ^4.2 ^4.3 Wang, H et al. (2011) Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria. J. Lipid Res. 52 2159-68 PubMed GONUTS page

[PMID:21148142-5] 5.0 ^5.1 ^5.2 ^5.3 Granneman, JG et al. (2011) Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase. J. Biol. Chem. 286 5126-35 PubMed GONUTS page

[PMID:19717842-6] 6.0 ^6.1 Wang, H et al. (2009) Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins. J. Biol. Chem. 284 32116-25 PubMed GONUTS page

[PMID:17130488-7] 7.0 ^7.1 ^7.2 Wolins, NE et al. (2006) OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes 55 3418-28 PubMed GONUTS page

[PMID:23345411-8] Wang, H et al. (2013) Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction. J. Lipid Res. 54 953-65 PubMed GONUTS page

[PMID:16571721-9] 9.0 ^9.1 Yamaguchi, T et al. (2006) MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 281 14232-40 PubMed GONUTS page

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MOUSE:PLIN5

Contents

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