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MOUSE:PLIN5
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Plin5 (synonyms: Lsdp5, Mldp, Oxpat, Pat1) | |
Protein Name(s) | Perilipin-5
Lipid droplet-associated protein PAT-1 Lipid storage droplet protein 5 Myocardial LD protein | |
External Links | ||
UniProt | Q8BVZ1 | |
EMBL | DQ473305 AY919875 AK075872 BC024138 | |
CCDS | CCDS37662.1 | |
RefSeq | NP_001070816.1 NP_080150.2 | |
UniGene | Mm.254985 | |
ProteinModelPortal | Q8BVZ1 | |
SMR | Q8BVZ1 | |
BioGrid | 211843 | |
PhosphoSite | Q8BVZ1 | |
MaxQB | Q8BVZ1 | |
PaxDb | Q8BVZ1 | |
PRIDE | Q8BVZ1 | |
Ensembl | ENSMUST00000019808 ENSMUST00000113072 | |
GeneID | 66968 | |
KEGG | mmu:66968 | |
UCSC | uc008daz.1 | |
CTD | 440503 | |
MGI | MGI:1914218 | |
eggNOG | NOG68472 | |
GeneTree | ENSGT00500000044795 | |
HOGENOM | HOG000033816 | |
HOVERGEN | HBG002935 | |
InParanoid | Q8BVZ1 | |
OMA | CRLAEHC | |
OrthoDB | EOG7SN8CD | |
PhylomeDB | Q8BVZ1 | |
TreeFam | TF328397 | |
NextBio | 323159 | |
PRO | PR:Q8BVZ1 | |
Proteomes | UP000000589 | |
Bgee | Q8BVZ1 | |
Genevestigator | Q8BVZ1 | |
GO | GO:0005737 GO:0005829 GO:0005811 GO:0005739 GO:0042802 GO:0035473 GO:0006629 GO:0034389 GO:0019915 GO:0051646 GO:0031999 GO:0060192 GO:0050995 GO:0035359 GO:2000378 GO:0010897 GO:0032000 GO:0060193 GO:0010884 GO:0010890 GO:0010867 | |
InterPro | IPR004279 | |
PANTHER | PTHR14024 | |
Pfam | PF03036 | |
PIRSF | PIRSF036881 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0010890 |
positive regulation of sequestering of triglyceride |
ECO:0000314 |
P |
Figure #3 shows that "a higher concentration of TGs was observed in cells overexpressing LSDP5 compared with controls". |
complete | |||||
GO:0010890 |
positive regulation of sequestering of triglyceride |
ECO:0000314 |
P |
Figure 3b says that "lipid droplets were stained using BODIPY (neutral lipid dye). BODIPY fluorescence increased in cells overexpressing LSDP5. The mRNA level of adipophilin, a protein that coats lipid droplets, was increased in cells overexpressing LSDP5 (Figure 3C). The amount of TGs in cells overexpressing LSDP5 also significantly increased, compared to control cells, which was determined using a TG test kit (P=0.014) (Figure 3D). The phenotypes of increased lipid droplet storage and increased TG contents were also observed in primary hepatocytes (Figure S1). These data demonstrate that the overexpression of LSDP5 is associated with an increased cellular TG content". |
complete | |||||
GO:0019915 |
lipid storage |
ECO:0000314 |
P |
Figure 3 shows overexpression of Lspd5 causes increased lipid storage |
complete | |||||
GO:0005811 |
lipid particle |
ECO:0000314 |
C |
Figure 1 shows Lsdp5 colocalized with lipid droplets. |
complete | |||||
part_of |
GO:0005811 |
lipid droplet |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019915 |
lipid storage |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000378 |
negative regulation of reactive oxygen species metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060193 |
positive regulation of lipase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060192 |
negative regulation of lipase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051646 |
mitochondrion localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050995 |
negative regulation of lipid catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0035473 |
lipase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0035473 |
lipase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035359 |
negative regulation of peroxisome proliferator activated receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034389 |
lipid droplet organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032000 |
positive regulation of fatty acid beta-oxidation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031999 |
negative regulation of fatty acid beta-oxidation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031999 |
negative regulation of fatty acid beta-oxidation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031999 |
negative regulation of fatty acid beta-oxidation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019915 |
lipid storage |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010897 |
negative regulation of triglyceride catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010897 |
negative regulation of triglyceride catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010890 |
positive regulation of sequestering of triglyceride |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010884 |
positive regulation of lipid storage |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010867 |
positive regulation of triglyceride biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010867 |
positive regulation of triglyceride biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010867 |
positive regulation of triglyceride biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005811 |
lipid droplet |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0005811 |
lipid droplet |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060193 |
positive regulation of lipase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1589602 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0035473 |
lipase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1589602 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0032000 |
positive regulation of fatty acid beta-oxidation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1589602 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0010890 |
positive regulation of sequestering of triglyceride |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1589602 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0010884 |
positive regulation of lipid storage |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1589602 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16105) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005811 |
lipid droplet |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16105)|part_of:(CL:0000178) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005811 |
lipid droplet |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1589602 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1589602 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060193 |
positive regulation of lipase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:M0R7Z9 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0035473 |
lipase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:M0R7Z9 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032000 |
positive regulation of fatty acid beta-oxidation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:M0R7Z9 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010890 |
positive regulation of sequestering of triglyceride |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:M0R7Z9 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010884 |
positive regulation of lipid storage |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:M0R7Z9 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005811 |
lipid droplet |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:M0R7Z9 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:M0R7Z9 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005811 |
lipid droplet |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Li, H et al. (2012) LSDP5 enhances triglyceride storage in hepatocytes by influencing lipolysis and fatty acid β-oxidation of lipid droplets. PLoS ONE 7 e36712 PubMed GONUTS page
- ↑ Dodge, LD et al. (1988) Concurrent lumbar spinal stenosis and peripheral vascular disease. A report of nine patients. Clin. Orthop. Relat. Res. 141-8 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Kuramoto, K et al. (2012) Perilipin 5, a lipid droplet-binding protein, protects heart from oxidative burden by sequestering fatty acid from excessive oxidation. J. Biol. Chem. 287 23852-63 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Wang, H et al. (2011) Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria. J. Lipid Res. 52 2159-68 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Granneman, JG et al. (2011) Interactions of perilipin-5 (Plin5) with adipose triglyceride lipase. J. Biol. Chem. 286 5126-35 PubMed GONUTS page
- ↑ 6.0 6.1 Wang, H et al. (2009) Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins. J. Biol. Chem. 284 32116-25 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Wolins, NE et al. (2006) OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes 55 3418-28 PubMed GONUTS page
- ↑ Wang, H et al. (2013) Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction. J. Lipid Res. 54 953-65 PubMed GONUTS page
- ↑ 9.0 9.1 Yamaguchi, T et al. (2006) MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 281 14232-40 PubMed GONUTS page
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- GO:0010897 ! negative regulation of triglyceride catabolic process
- GO:0031999 ! negative regulation of fatty acid beta-oxidation
- GO:0035359 ! negative regulation of peroxisome proliferator activated receptor signaling pathway
- GO:0050995 ! negative regulation of lipid catabolic process
- GO:0060192 ! negative regulation of lipase activity
- GO:2000378 ! negative regulation of reactive oxygen species metabolic process
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